Difference between revisions of "Pyloric gland adenoma"
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'''Pyloric gland adenoma''' is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = | |||
| Micro = foveolar-type glands with eosinophilic (or clear) cytoplasm, nuclei with or without dysplasia | |||
| Subtypes = | |||
| LMDDx = foveolar-type [[gastric adenoma]], well-differentiated [[gastric adenocarcinoma]] | |||
| Stains = | |||
| IHC = MUC6 +ve, MUC5AC +ve, Ki-67 high | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[stomach]], [[duodenum]], [[gallbladder]], others | |||
| Assdx = well-differentiated [[gastric adenocarcinoma]], [[autoimmune gastritis]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = polyp | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other [[GI polyps|polyps]] | |||
| Tx = excision | |||
}} | |||
'''Pyloric gland adenoma''', abbreviated '''PGA''', is an uncommon [[gastrointestinal pathology|gastrointestinal]] lesion. | |||
==General== | ==General== | ||
<ref>{{Cite journal | last1 = Vieth | first1 = M. | last2 = Vogel | first2 = C. | last3 = Kushima | first3 = R. | last4 = Borchard | first4 = F. | last5 = Stolte | first5 = M. | title = Pyloric gland adenoma-- how to diagnose? | journal = Cesk Patol | volume = 42 | issue = 1 | pages = 4-7 | month = Jan | year = 2006 | doi = | PMID = 16506593 }}</ref> | *Approximately 3% of gastric polyps.<ref name=pmid16506593>{{Cite journal | last1 = Vieth | first1 = M. | last2 = Vogel | first2 = C. | last3 = Kushima | first3 = R. | last4 = Borchard | first4 = F. | last5 = Stolte | first5 = M. | title = Pyloric gland adenoma-- how to diagnose? | journal = Cesk Patol | volume = 42 | issue = 1 | pages = 4-7 | month = Jan | year = 2006 | doi = | PMID = 16506593 }}</ref> | ||
*Associated with [[autoimmune gastritis]].<ref>{{Cite journal | last1 = Vieth | first1 = M. | last2 = Montgomery | first2 = EA. | title = Some observations on pyloric gland adenoma: an uncommon and long ignored entity! | journal = J Clin Pathol | volume = | issue = | pages = | month = Aug | year = 2014 | doi = 10.1136/jclinpath-2014-202553 | PMID = 25092673 }}</ref> | |||
*More often seen in women as with autoimmune gastritis. | |||
*Associated with [[gastric adenocarcinoma]]. | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid18830123/> | |||
*Round mildly irregular foveolar-type glands with: | |||
**Nuclei without dysplasia (round and basally located nuclei) or with dysplasia. | |||
**Moderate eosinophilic (or clear) cytoplasm. | |||
DDx: | DDx: | ||
*[[Gastric adenoma]]. | *[[Gastric adenoma]], foveolar-type. | ||
*[[Adenocarcinoma of the stomach]]. | *[[Adenocarcinoma of the stomach]], well-differentiated. | ||
===Images=== | |||
*[http://www.flickriver.com/photos/lunarcaustic/3488308419/ Tubulare adenoma, pyloric gland-type (flickriver.com)]. | |||
==IHC== | ==IHC== | ||
*Ki-67 high. | *Ki-67 high. | ||
*MUC6 +ve.{{ | *MUC6 +ve.<ref name=pmid18830123>{{Cite journal | last1 = Chen | first1 = ZM. | last2 = Scudiere | first2 = JR. | last3 = Abraham | first3 = SC. | last4 = Montgomery | first4 = E. | title = Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma. | journal = Am J Surg Pathol | volume = 33 | issue = 2 | pages = 186-93 | month = Feb | year = 2009 | doi = 10.1097/PAS.0b013e31817d7ff4 | PMID = 18830123 }}</ref> | ||
**Negative in foveolar-type gastric adenomas. | |||
*MUC5AC +ve.<ref name=pmid18830123/> | |||
==See also== | |||
*[[Autoimmune gastritis]]. | |||
==References== | ==References== | ||
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[[Category:Gastrointestinal pathology]] | [[Category:Gastrointestinal pathology]] | ||
[[Category:Diagnosis]] | |||
Latest revision as of 17:53, 15 September 2022
| Pyloric gland adenoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | foveolar-type glands with eosinophilic (or clear) cytoplasm, nuclei with or without dysplasia |
| LM DDx | foveolar-type gastric adenoma, well-differentiated gastric adenocarcinoma |
| IHC | MUC6 +ve, MUC5AC +ve, Ki-67 high |
| Site | stomach, duodenum, gallbladder, others |
|
| |
| Associated Dx | well-differentiated gastric adenocarcinoma, autoimmune gastritis |
| Prevalence | uncommon |
| Endoscopy | polyp |
| Prognosis | benign |
| Clin. DDx | other polyps |
| Treatment | excision |
Pyloric gland adenoma, abbreviated PGA, is an uncommon gastrointestinal lesion.
General
- Approximately 3% of gastric polyps.[1]
- Associated with autoimmune gastritis.[2]
- More often seen in women as with autoimmune gastritis.
- Associated with gastric adenocarcinoma.
Microscopic
Features:[3]
- Round mildly irregular foveolar-type glands with:
- Nuclei without dysplasia (round and basally located nuclei) or with dysplasia.
- Moderate eosinophilic (or clear) cytoplasm.
DDx:
- Gastric adenoma, foveolar-type.
- Adenocarcinoma of the stomach, well-differentiated.
Images
IHC
See also
References
- ↑ Vieth, M.; Vogel, C.; Kushima, R.; Borchard, F.; Stolte, M. (Jan 2006). "Pyloric gland adenoma-- how to diagnose?". Cesk Patol 42 (1): 4-7. PMID 16506593.
- ↑ Vieth, M.; Montgomery, EA. (Aug 2014). "Some observations on pyloric gland adenoma: an uncommon and long ignored entity!". J Clin Pathol. doi:10.1136/jclinpath-2014-202553. PMID 25092673.
- ↑ 3.0 3.1 3.2 Chen, ZM.; Scudiere, JR.; Abraham, SC.; Montgomery, E. (Feb 2009). "Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.". Am J Surg Pathol 33 (2): 186-93. doi:10.1097/PAS.0b013e31817d7ff4. PMID 18830123.