Difference between revisions of "Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma"
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* | *Irregular elongated glands ("microcystic elongated fragmented") - at deep aspect of tumour. | ||
** | **Surrounded by stromal mucin.<ref name=pmid19900084>{{cite journal |authors=Stewart CJ, Brennan BA, Leung YC, Little L |title=MELF pattern invasion in endometrial carcinoma: association with low grade, myoinvasive endometrioid tumours, focal mucinous differentiation and vascular invasion |journal=Pathology |volume=41 |issue=5 |pages=454–9 |date=2009 |pmid=19900084 |doi=10.1080/00313020903041135 |url=}}</ref> | ||
*Lymphovascular invasion more commmon than non-MELF carcinomas.<ref name=pmid24487466>{{cite journal |vauthor=Hertel JD, Huettner PC, Pfeifer JD |title=Lymphovascular space invasion in microcystic elongated and fragmented (MELF)-pattern well-differentiated endometrioid adenocarcinoma is associated with a higher rate of lymph node metastasis |journal=Int. J. Gynecol. Pathol. |volume=33 |issue=2 |pages=127–34 |date=March 2014 |pmid=24487466 |doi=10.1097/PGP.0b013e318285657b |url=}}</ref> | **May be confused with LVI. | ||
*Lymphovascular invasion more commmon than non-MELF carcinomas.<ref name=pmid24487466>{{cite journal |vauthor=Hertel JD, Huettner PC, Pfeifer JD |title=Lymphovascular space invasion in microcystic elongated and fragmented (MELF)-pattern well-differentiated endometrioid adenocarcinoma is associated with a higher rate of lymph node metastasis |journal=Int. J. Gynecol. Pathol. |volume=33 |issue=2 |pages=127–34 |date=March 2014 |pmid=24487466 |doi=10.1097/PGP.0b013e318285657b |url=}}</ref> | |||
Note: | |||
*Mucinous differentiation common in MELF. | |||
==See also== | ==See also== |
Revision as of 15:48, 5 March 2020
Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma is a pattern of endometrioid endometrial carcinoma. Microcystic elongated and fragmented glands is typically abbreviated as MELF.[1]
General
- MELF pattern is a poor prognosticator.[2]
Microscopic
Features:
- Irregular elongated glands ("microcystic elongated fragmented") - at deep aspect of tumour.
- Surrounded by stromal mucin.[3]
- May be confused with LVI.
- Lymphovascular invasion more commmon than non-MELF carcinomas.[2]
Note:
- Mucinous differentiation common in MELF.
See also
References
- ↑ Euscher, E.; Fox, P.; Bassett, R.; Al-Ghawi, H.; Ali-Fehmi, R.; Barbuto, D.; Djordjevic, B.; Frauenhoffer, E. et al. (Nov 2013). "The pattern of myometrial invasion as a predictor of lymph node metastasis or extrauterine disease in low-grade endometrial carcinoma.". Am J Surg Pathol 37 (11): 1728-36. doi:10.1097/PAS.0b013e318299f2ab. PMID 24061515.
- ↑ 2.0 2.1 "Lymphovascular space invasion in microcystic elongated and fragmented (MELF)-pattern well-differentiated endometrioid adenocarcinoma is associated with a higher rate of lymph node metastasis". Int. J. Gynecol. Pathol. 33 (2): 127–34. March 2014. doi:10.1097/PGP.0b013e318285657b. PMID 24487466.
- ↑ Stewart CJ, Brennan BA, Leung YC, Little L (2009). "MELF pattern invasion in endometrial carcinoma: association with low grade, myoinvasive endometrioid tumours, focal mucinous differentiation and vascular invasion". Pathology 41 (5): 454–9. doi:10.1080/00313020903041135. PMID 19900084.