Difference between revisions of "Atypical teratoid/rhabdoid tumour"
Jump to navigation
Jump to search
Jensflorian (talk | contribs) (→Microscopic: DDx) |
|||
| (12 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = ATRT-HE-Overview.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = AT/RT. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = cellular tumour with small round cells usu. with a prominent nucleolus, rhabdoid cells (eosinophilic granular cytoplasm + eccentric nucleus), mitoses. +/-necrosis (common) | | Micro = cellular tumour with small round cells usu. with a prominent nucleolus, rhabdoid cells (eosinophilic granular cytoplasm + eccentric nucleus), mitoses. +/-necrosis (common) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[primitive neuroectodermal tumour]] (PNET), [[medulloblastoma]], [[diffuse astrocytoma]], [[choroid plexus carcinoma]],[[embryonal carcinoma]] | | LMDDx = [[primitive neuroectodermal tumour]] (PNET), [[medulloblastoma]], [[diffuse astrocytoma]], [[choroid plexus carcinoma]], [[embryonal carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = INI1 -ve, S-100 +ve, EMA +ve, SMA +ve | | IHC = INI1 -ve, S-100 +ve, EMA +ve, SMA +ve | ||
| Line 39: | Line 39: | ||
*Usually supratentorial, occasionally in posterior fossa, case reports of spinal cord. | *Usually supratentorial, occasionally in posterior fossa, case reports of spinal cord. | ||
*Individuals usually <3 years old, uncommon in adults.<ref name=pmid24477665>{{Cite journal | last1 = Kanoto | first1 = M. | last2 = Toyoguchi | first2 = Y. | last3 = Hosoya | first3 = T. | last4 = Kuchiki | first4 = M. | last5 = Sugai | first5 = Y. | title = Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review. | journal = Clin Neuroradiol | volume = | issue = | pages = | month = Jan | year = 2014 | doi = 10.1007/s00062-013-0282-2 | PMID = 24477665 }}</ref> | *Individuals usually <3 years old, uncommon in adults.<ref name=pmid24477665>{{Cite journal | last1 = Kanoto | first1 = M. | last2 = Toyoguchi | first2 = Y. | last3 = Hosoya | first3 = T. | last4 = Kuchiki | first4 = M. | last5 = Sugai | first5 = Y. | title = Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review. | journal = Clin Neuroradiol | volume = | issue = | pages = | month = Jan | year = 2014 | doi = 10.1007/s00062-013-0282-2 | PMID = 24477665 }}</ref> | ||
*Prognosis very poor.<ref | *Prognosis very poor, but long-term survivors reported.<ref>{{Cite journal | last1 = von Hoff | first1 = K. | last2 = Hinkes | first2 = B. | last3 = Dannenmann-Stern | first3 = E. | last4 = von Bueren | first4 = AO. | last5 = Warmuth-Metz | first5 = M. | last6 = Soerensen | first6 = N. | last7 = Emser | first7 = A. | last8 = Zwiener | first8 = I. | last9 = Schlegel | first9 = PG. | title = Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database. | journal = Pediatr Blood Cancer | volume = 57 | issue = 6 | pages = 978-85 | month = Dec | year = 2011 | doi = 10.1002/pbc.23236 | PMID = 21796761 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
| Line 45: | Line 45: | ||
*Cellular. | *Cellular. | ||
*Small round cells usu. with a prominent nucleolus. | *Small round cells usu. with a prominent nucleolus. | ||
*Rhabdoid cells. | *[[Rhabdoid]] cells. | ||
**Cells with eosinophilic granular cytoplasm + eccentric nucleus. | **Cells with eosinophilic granular cytoplasm + eccentric nucleus. | ||
*Mitoses. | *Mitoses. | ||
| Line 53: | Line 53: | ||
*[[Primitive neuroectodermal tumour]] (PNET). | *[[Primitive neuroectodermal tumour]] (PNET). | ||
*[[Medulloblastoma]]. | *[[Medulloblastoma]]. | ||
*[[ | *[[Small cell carcinoma]] metastasis. | ||
*[[Choroid plexus carcinoma]]. | *[[Choroid plexus carcinoma]]. | ||
*[[Embryonal carcinoma]]. | *[[Embryonal carcinoma]]. | ||
*[[Rhabdoid meningioma]]. | |||
*Intracranial [[Desmoplastic small round cell tumour]]. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Rhabdoidtumourcell.jpg | Rhabdoid tumour cell. (WC) | Image:Rhabdoidtumourcell.jpg | Rhabdoid tumour cell. (WC/marvin101) | ||
Image:ATRT-HE-Overview.jpg | AT/RT. (WC) | Image:ATRT-HE-Overview.jpg | AT/RT. (WC/marvin101) | ||
Image:ATRT-INI1.jpg | AT/RT -ve for INI1. (WC) | Image:ATRT-INI1.jpg | AT/RT -ve for INI1. (WC/marvin101) | ||
Image:Rhabdoid cells ATRT1.jpg | Rhabdoid cells in a AT/RT (WC/jensflorian) | |||
Image:ATRT-MRI.jpg | AT/RT may be found anywhere in the brain or spinal cord (WC/marvin101) | |||
Image:Neuropathology_case_IV_01.jpg | AT/RT low mag.(WC/jensflorian) | |||
Image:Neuropathology_case_IV_02.jpg | AT/RT intermed. mag.(WC/jensflorian) | |||
Image:Neuropathology_case_IV_03.jpg | AT/RT high mag.(WC/jensflorian) | |||
Image:Neuropathology_case_IV_04.jpg | INI1 loss in a AT/RT. (WC/jensflorian) | |||
</gallery> | </gallery> | ||
www: | www: | ||
| Line 67: | Line 75: | ||
==IHC== | ==IHC== | ||
* | * [[INI1]]-ve ([[AKA]] ''BAF-47'', [[AKA]] ''SMARCB1'' - the HGNC symbol<ref name=omim601607>{{OMIM|601607}}</ref>) - virtually diagnostic (4/4 cases<ref name=pmid19212771/>). | ||
**Endothelial cells +ve control. | **Endothelial cells +ve control. | ||
*S-100 +ve (4/4 cases<ref name=pmid19212771>{{Cite journal | last1 = Ertan | first1 = Y. | last2 = Sezak | first2 = M. | last3 = Turhan | first3 = T. | last4 = Kantar | first4 = M. | last5 = Erşahin | first5 = Y. | last6 = Mutluer | first6 = S. | last7 = Vergin | first7 = C. | last8 = Oniz | first8 = H. | last9 = Akalin | first9 = T. | title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases. | journal = Childs Nerv Syst | volume = 25 | issue = 6 | pages = 707-11 | month = Jun | year = 2009 | doi = 10.1007/s00381-009-0811-0 | PMID = 19212771 }}</ref>. | *S-100 +ve (4/4 cases<ref name=pmid19212771>{{Cite journal | last1 = Ertan | first1 = Y. | last2 = Sezak | first2 = M. | last3 = Turhan | first3 = T. | last4 = Kantar | first4 = M. | last5 = Erşahin | first5 = Y. | last6 = Mutluer | first6 = S. | last7 = Vergin | first7 = C. | last8 = Oniz | first8 = H. | last9 = Akalin | first9 = T. | title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases. | journal = Childs Nerv Syst | volume = 25 | issue = 6 | pages = 707-11 | month = Jun | year = 2009 | doi = 10.1007/s00381-009-0811-0 | PMID = 19212771 }}</ref>). | ||
**Few other brain tumours express it. | **Few other brain tumours express it. | ||
*Vimentin +ve - perinuclear condensation (4/4 cases<ref name=pmid19212771/>). | *Vimentin +ve - perinuclear condensation (4/4 cases<ref name=pmid19212771/>). | ||
*LIN28 focally +ve <ref>{{Cite journal | last1 = Korshunov | first1 = A. | last2 = Ryzhova | first2 = M. | last3 = Jones | first3 = DT. | last4 = Northcott | first4 = PA. | last5 = van Sluis | first5 = P. | last6 = Volckmann | first6 = R. | last7 = Koster | first7 = J. | last8 = Versteeg | first8 = R. | last9 = Cowdrey | first9 = C. | title = LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). | journal = Acta Neuropathol | volume = 124 | issue = 6 | pages = 875-81 | month = Dec | year = 2012 | doi = 10.1007/s00401-012-1068-3 | PMID = 23161096 }}</ref> | |||
Others: | Others: | ||
*GFAP +ve (focal - in tumour cells). | *GFAP +ve (focal - in tumour cells). | ||
*EMA +ve - patchy cytoplasmic (4/4 cases<ref name=pmid19212771/>). | *EMA +ve - patchy cytoplasmic (4/4 cases<ref name=pmid19212771/>). | ||
*Smooth muscle actin +ve.(4/4 cases<ref name=pmid19212771/>). | *Smooth muscle actin +ve.(4/4 cases<ref name=pmid19212771/>). <ref>{{Cite journal | last1 = Lee | first1 = MC. | last2 = Park | first2 = SK. | last3 = Lim | first3 = JS. | last4 = Jung | first4 = S. | last5 = Kim | first5 = JH. | last6 = Woo | first6 = YJ. | last7 = Lee | first7 = JS. | last8 = Kim | first8 = HI. | last9 = Jeong | first9 = MJ. | title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinico-pathological study. | journal = Neuropathology | volume = 22 | issue = 4 | pages = 252-60 | month = Dec | year = 2002 | doi = | PMID = 12564764 }}</ref> | ||
*Cytokeratin +ve.{{ | *Cytokeratin +ve.<ref>{{Cite journal | last1 = Lee | first1 = MC. | last2 = Park | first2 = SK. | last3 = Lim | first3 = JS. | last4 = Jung | first4 = S. | last5 = Kim | first5 = JH. | last6 = Woo | first6 = YJ. | last7 = Lee | first7 = JS. | last8 = Kim | first8 = HI. | last9 = Jeong | first9 = MJ. | title = Atypical teratoid/rhabdoid tumor of the central nervous system: clinico-pathological study. | journal = Neuropathology | volume = 22 | issue = 4 | pages = 252-60 | month = Dec | year = 2002 | doi = | PMID = 12564764 }}</ref> | ||
*Kir 7.1 occasionally +ve<ref>{{Cite journal | last1 = Schittenhelm | first1 = J. | last2 = Nagel | first2 = C. | last3 = Meyermann | first3 = R. | last4 = Beschorner | first4 = R. | title = Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors. | journal = Neuropathology | volume = 31 | issue = 5 | pages = 461-7 | month = Oct | year = 2011 | doi = 10.1111/j.1440-1789.2010.01189.x | PMID = 21276081 }}</ref> | |||
==Molecular== | |||
*Almost all cases associated with SMARCB1 abberations.<ref>{{Cite journal | last1 = Hasselblatt | first1 = M. | last2 = Isken | first2 = S. | last3 = Linge | first3 = A. | last4 = Eikmeier | first4 = K. | last5 = Jeibmann | first5 = A. | last6 = Oyen | first6 = F. | last7 = Nagel | first7 = I. | last8 = Richter | first8 = J. | last9 = Bartelheim | first9 = K. | title = High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors. | journal = Genes Chromosomes Cancer | volume = 52 | issue = 2 | pages = 185-90 | month = Feb | year = 2013 | doi = 10.1002/gcc.22018 | PMID = 23074045 }}</ref> | |||
*Single cases with SMARCA4 mutation.<ref>{{Cite journal | last1 = Hasselblatt | first1 = M. | last2 = Gesk | first2 = S. | last3 = Oyen | first3 = F. | last4 = Rossi | first4 = S. | last5 = Viscardi | first5 = E. | last6 = Giangaspero | first6 = F. | last7 = Giannini | first7 = C. | last8 = Judkins | first8 = AR. | last9 = Frühwald | first9 = MC. | title = Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression. | journal = Am J Surg Pathol | volume = 35 | issue = 6 | pages = 933-5 | month = Jun | year = 2011 | doi = 10.1097/PAS.0b013e3182196a39 | PMID = 21566516 }}</ref> | |||
* Two molecular subgroups:<ref>{{Cite journal | last1 = Torchia | first1 = J. | last2 = Picard | first2 = D. | last3 = Lafay-Cousin | first3 = L. | last4 = Hawkins | first4 = CE. | last5 = Kim | first5 = SK. | last6 = Letourneau | first6 = L. | last7 = Ra | first7 = YS. | last8 = Ho | first8 = KC. | last9 = Chan | first9 = TS. | title = Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis. | journal = Lancet Oncol | volume = 16 | issue = 5 | pages = 569-82 | month = May | year = 2015 | doi = 10.1016/S1470-2045(15)70114-2 | PMID = 25882982 }}</ref> | |||
** Group 1: usu. supratentorial, ASCL1-positive: high-risk. | |||
** Group 2: usu. infratentorial, BMP-signalling: very high risk. | |||
==See also== | ==See also== | ||
| Line 83: | Line 100: | ||
*[[Extrarenal malignant rhabdoid tumour]]. | *[[Extrarenal malignant rhabdoid tumour]]. | ||
*[[Renal malignant rhabdoid tumour]]. | *[[Renal malignant rhabdoid tumour]]. | ||
*[[Miscellaneous ovarian tumours|Ovarian small cell carcinoma of the hypercalcemic type]] | |||
==References== | ==References== | ||
| Line 89: | Line 107: | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | [[Category:Neuropathology tumours]] | ||
[[Category:Small round blue cell tumours]] | |||
Latest revision as of 11:00, 21 January 2020
| Atypical teratoid/rhabdoid tumour | |
|---|---|
| Diagnosis in short | |
 AT/RT. H&E stain. | |
|
| |
| LM | cellular tumour with small round cells usu. with a prominent nucleolus, rhabdoid cells (eosinophilic granular cytoplasm + eccentric nucleus), mitoses. +/-necrosis (common) |
| LM DDx | primitive neuroectodermal tumour (PNET), medulloblastoma, diffuse astrocytoma, choroid plexus carcinoma, embryonal carcinoma |
| IHC | INI1 -ve, S-100 +ve, EMA +ve, SMA +ve |
| Site | CNS - typically supratentorial |
|
| |
| Clinical history | usu. <3 years olds, occasionally adults |
| Prevalence | uncommon - esp. in adults |
| Prognosis | very poor |
Atypical teratoid/rhabdoid tumour, abbreviated AT/RT, is malignant tumour usually found supratentorially.
It may be written atypical teratoid rhabdoid tumour (abbreviated ATRT) or atypical teratoid-rhabdoid tumour (abbreviated AT-RT).
It should not be confused with the extrarenal malignant rhabdoid tumour.
General
- Usually supratentorial, occasionally in posterior fossa, case reports of spinal cord.
- Individuals usually <3 years old, uncommon in adults.[1]
- Prognosis very poor, but long-term survivors reported.[2]
Microscopic
Features:
- Cellular.
- Small round cells usu. with a prominent nucleolus.
- Rhabdoid cells.
- Cells with eosinophilic granular cytoplasm + eccentric nucleus.
- Mitoses.
- +/-Necrosis (common).
DDx:
- Primitive neuroectodermal tumour (PNET).
- Medulloblastoma.
- Small cell carcinoma metastasis.
- Choroid plexus carcinoma.
- Embryonal carcinoma.
- Rhabdoid meningioma.
- Intracranial Desmoplastic small round cell tumour.
Images
Rhabdoid tumour cell. (WC/marvin101)
AT/RT. (WC/marvin101)
AT/RT -ve for INI1. (WC/marvin101)
Rhabdoid cells in a AT/RT (WC/jensflorian)
AT/RT may be found anywhere in the brain or spinal cord (WC/marvin101)
AT/RT low mag.(WC/jensflorian)
AT/RT intermed. mag.(WC/jensflorian)
AT/RT high mag.(WC/jensflorian)
INI1 loss in a AT/RT. (WC/jensflorian)
www:
IHC
- INI1-ve (AKA BAF-47, AKA SMARCB1 - the HGNC symbol[3]) - virtually diagnostic (4/4 cases[4]).
- Endothelial cells +ve control.
- S-100 +ve (4/4 cases[4]).
- Few other brain tumours express it.
- Vimentin +ve - perinuclear condensation (4/4 cases[4]).
- LIN28 focally +ve [5]
Others:
- GFAP +ve (focal - in tumour cells).
- EMA +ve - patchy cytoplasmic (4/4 cases[4]).
- Smooth muscle actin +ve.(4/4 cases[4]). [6]
- Cytokeratin +ve.[7]
- Kir 7.1 occasionally +ve[8]
Molecular
- Almost all cases associated with SMARCB1 abberations.[9]
- Single cases with SMARCA4 mutation.[10]
- Two molecular subgroups:[11]
- Group 1: usu. supratentorial, ASCL1-positive: high-risk.
- Group 2: usu. infratentorial, BMP-signalling: very high risk.
See also
- Neuropathology tumours.
- Extrarenal malignant rhabdoid tumour.
- Renal malignant rhabdoid tumour.
- Ovarian small cell carcinoma of the hypercalcemic type
References
- ↑ Kanoto, M.; Toyoguchi, Y.; Hosoya, T.; Kuchiki, M.; Sugai, Y. (Jan 2014). "Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review.". Clin Neuroradiol. doi:10.1007/s00062-013-0282-2. PMID 24477665.
- ↑ von Hoff, K.; Hinkes, B.; Dannenmann-Stern, E.; von Bueren, AO.; Warmuth-Metz, M.; Soerensen, N.; Emser, A.; Zwiener, I. et al. (Dec 2011). "Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database.". Pediatr Blood Cancer 57 (6): 978-85. doi:10.1002/pbc.23236. PMID 21796761.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 601607
- ↑ 4.0 4.1 4.2 4.3 4.4 Ertan, Y.; Sezak, M.; Turhan, T.; Kantar, M.; Erşahin, Y.; Mutluer, S.; Vergin, C.; Oniz, H. et al. (Jun 2009). "Atypical teratoid/rhabdoid tumor of the central nervous system: clinicopathologic and immunohistochemical features of four cases.". Childs Nerv Syst 25 (6): 707-11. doi:10.1007/s00381-009-0811-0. PMID 19212771.
- ↑ Korshunov, A.; Ryzhova, M.; Jones, DT.; Northcott, PA.; van Sluis, P.; Volckmann, R.; Koster, J.; Versteeg, R. et al. (Dec 2012). "LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR).". Acta Neuropathol 124 (6): 875-81. doi:10.1007/s00401-012-1068-3. PMID 23161096.
- ↑ Lee, MC.; Park, SK.; Lim, JS.; Jung, S.; Kim, JH.; Woo, YJ.; Lee, JS.; Kim, HI. et al. (Dec 2002). "Atypical teratoid/rhabdoid tumor of the central nervous system: clinico-pathological study.". Neuropathology 22 (4): 252-60. PMID 12564764.
- ↑ Lee, MC.; Park, SK.; Lim, JS.; Jung, S.; Kim, JH.; Woo, YJ.; Lee, JS.; Kim, HI. et al. (Dec 2002). "Atypical teratoid/rhabdoid tumor of the central nervous system: clinico-pathological study.". Neuropathology 22 (4): 252-60. PMID 12564764.
- ↑ Schittenhelm, J.; Nagel, C.; Meyermann, R.; Beschorner, R. (Oct 2011). "Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors.". Neuropathology 31 (5): 461-7. doi:10.1111/j.1440-1789.2010.01189.x. PMID 21276081.
- ↑ Hasselblatt, M.; Isken, S.; Linge, A.; Eikmeier, K.; Jeibmann, A.; Oyen, F.; Nagel, I.; Richter, J. et al. (Feb 2013). "High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors.". Genes Chromosomes Cancer 52 (2): 185-90. doi:10.1002/gcc.22018. PMID 23074045.
- ↑ Hasselblatt, M.; Gesk, S.; Oyen, F.; Rossi, S.; Viscardi, E.; Giangaspero, F.; Giannini, C.; Judkins, AR. et al. (Jun 2011). "Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression.". Am J Surg Pathol 35 (6): 933-5. doi:10.1097/PAS.0b013e3182196a39. PMID 21566516.
- ↑ Torchia, J.; Picard, D.; Lafay-Cousin, L.; Hawkins, CE.; Kim, SK.; Letourneau, L.; Ra, YS.; Ho, KC. et al. (May 2015). "Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.". Lancet Oncol 16 (5): 569-82. doi:10.1016/S1470-2045(15)70114-2. PMID 25882982.