Difference between revisions of "Epstein-Barr virus-associated smooth muscle tumour"
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'''[[Epstein-Barr virus]]-associated smooth muscle tumour''' is a very uncommon [[soft tissue lesions|soft tissue lesion]].<ref name=pmid16330945>{{Cite journal | last1 = Deyrup | first1 = AT. | last2 = Lee | first2 = VK. | last3 = Hill | first3 = CE. | last4 = Cheuk | first4 = W. | last5 = Toh | first5 = HC. | last6 = Kesavan | first6 = S. | last7 = Chan | first7 = EW. | last8 = Weiss | first8 = SW. | title = Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 75-82 | month = Jan | year = 2006 | doi = | PMID = 16330945 }}</ref> | '''[[Epstein-Barr virus]]-associated smooth muscle tumour''', abbreviated '''EBV-SMT''', is a very uncommon [[soft tissue lesions|soft tissue lesion]].<ref name=pmid16330945>{{Cite journal | last1 = Deyrup | first1 = AT. | last2 = Lee | first2 = VK. | last3 = Hill | first3 = CE. | last4 = Cheuk | first4 = W. | last5 = Toh | first5 = HC. | last6 = Kesavan | first6 = S. | last7 = Chan | first7 = EW. | last8 = Weiss | first8 = SW. | title = Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. | journal = Am J Surg Pathol | volume = 30 | issue = 1 | pages = 75-82 | month = Jan | year = 2006 | doi = | PMID = 16330945 }}</ref> | ||
==General== | ==General== | ||
*Immunosuppressed individuals. | *Immunosuppressed individuals, e.g. individuals with [[HIV]]. | ||
*Caused by [[Epstein-Barr virus]]. | *Caused by [[Epstein-Barr virus]]. | ||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid16330945/> | ||
*Spindle | *Smooth muscle lesion: | ||
**Spindle cells in a [[fascicular]] arrangement. | |||
**Usually minimal nuclear atypia and few mitoses. | |||
*Lymphocytes. | |||
DDx: | DDx: | ||
*[[Gastrointestinal stromal tumour]]. | *[[Gastrointestinal stromal tumour]]. | ||
*[[Leiomyosarcoma]]. | *[[Leiomyosarcoma]]. | ||
*[[Leiomyoma]]. | |||
Image: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig2/ EBV-EMT (nih.gov)].<ref name=pmid20690046>{{Cite journal | last1 = Huang | first1 = J. | last2 = Loh | first2 = KS. | last3 = Petersson | first3 = F. | title = Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma. | journal = Head Neck Pathol | volume = 4 | issue = 4 | pages = 300-4 | month = Dec | year = 2010 | doi = 10.1007/s12105-010-0201-7 | PMID = 20690046 }} | |||
</ref> | |||
==IHC== | ==IHC== | ||
| Line 18: | Line 26: | ||
*CD34 -ve. | *CD34 -ve. | ||
*CD117 -ve. | *CD117 -ve. | ||
Image: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig4/ EBV-SMT (nih.gov)]. | |||
==Molecular== | |||
*[[EBER]] +ve.<ref name=pmid20690046/> | |||
==References== | ==References== | ||
| Line 23: | Line 37: | ||
[[Category:Soft tissue lesions]] | [[Category:Soft tissue lesions]] | ||
[[Category:Diagnosis]] | |||
Latest revision as of 18:03, 29 December 2019
Epstein-Barr virus-associated smooth muscle tumour, abbreviated EBV-SMT, is a very uncommon soft tissue lesion.[1]
General
- Immunosuppressed individuals, e.g. individuals with HIV.
- Caused by Epstein-Barr virus.
Microscopic
Features:[1]
- Smooth muscle lesion:
- Spindle cells in a fascicular arrangement.
- Usually minimal nuclear atypia and few mitoses.
- Lymphocytes.
DDx:
Image:
IHC
- SMA +ve
- Desmin +ve/-ve.
- CD34 -ve.
- CD117 -ve.
Image:
Molecular
References
- ↑ 1.0 1.1 Deyrup, AT.; Lee, VK.; Hill, CE.; Cheuk, W.; Toh, HC.; Kesavan, S.; Chan, EW.; Weiss, SW. (Jan 2006). "Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.". Am J Surg Pathol 30 (1): 75-82. PMID 16330945.
- ↑ 2.0 2.1 Huang, J.; Loh, KS.; Petersson, F. (Dec 2010). "Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma.". Head Neck Pathol 4 (4): 300-4. doi:10.1007/s12105-010-0201-7. PMID 20690046.