Difference between revisions of "SMARCB1-deficient sinonasal carcinoma"
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid28291122/> | Features:<ref name=pmid28291122/> | ||
*Pagetoid spread. | *Pagetoid spread of plasmacytoid or rhabdoid cells. | ||
*Cyst/pseudocyst like spaces. | |||
*Lack squamous dysplasia. | |||
*Lack of carcinoma in situ. | |||
DDx: | DDx: | ||
Revision as of 04:25, 18 March 2019
SMARCB1-deficient sinonasal carcinoma is a rare malignant tumour of the head and neck with loss of SMARCB1 staining.[1]
Microscopic
Features:[1]
- Pagetoid spread of plasmacytoid or rhabdoid cells.
- Cyst/pseudocyst like spaces.
- Lack squamous dysplasia.
- Lack of carcinoma in situ.
DDx:
IHC
- SMARCB1 (INI1) -ve.[1]
See also
References
- ↑ 1.0 1.1 1.2 Agaimy, A.; Hartmann, A.; Antonescu, CR.; Chiosea, SI.; El-Mofty, SK.; Geddert, H.; Iro, H.; Lewis, JS. et al. (Apr 2017). "SMARCB1 (INI-1)-deficient Sinonasal Carcinoma: A Series of 39 Cases Expanding the Morphologic and Clinicopathologic Spectrum of a Recently Described Entity.". Am J Surg Pathol 41 (4): 458-471. doi:10.1097/PAS.0000000000000797. PMID 28291122.