Difference between revisions of "Bullous diseases"

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*[http://dermatology.cdlib.org/94/NYU/Feb2002/021202-8b.jpg BP (dermatology.cdlib.org)].<ref>URL: [http://dermatology.cdlib.org/94/NYU/Feb2002/8.html http://dermatology.cdlib.org/94/NYU/Feb2002/8.html]. Accessed on: 20 March 2011.</ref>
*[http://dermatology.cdlib.org/94/NYU/Feb2002/021202-8b.jpg BP (dermatology.cdlib.org)].<ref>URL: [http://dermatology.cdlib.org/94/NYU/Feb2002/8.html http://dermatology.cdlib.org/94/NYU/Feb2002/8.html]. Accessed on: 20 March 2011.</ref>
*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/bullous_pemphigoid_higher_power.jpg BP (ucsf.edu)].<ref>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/bullous_pemphigoid.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/bullous_pemphigoid.html]. Accessed on: 20 March 2011.</ref>
*[http://missinglink.ucsf.edu/lm/DermatologyGlossary/img/Dermatology%20Glossary/Glossary%20Histo%20Images/bullous_pemphigoid_higher_power.jpg BP (ucsf.edu)].<ref>URL: [http://missinglink.ucsf.edu/lm/DermatologyGlossary/bullous_pemphigoid.html http://missinglink.ucsf.edu/lm/DermatologyGlossary/bullous_pemphigoid.html]. Accessed on: 20 March 2011.</ref>
DDx:
*Bullous lupus.


==Pemphigus vulgaris==
==Pemphigus vulgaris==

Revision as of 19:10, 19 April 2011

Bullous disease happens. Dermatopathologists help diagnose it.

DDx of bullous disease:[1]

  • Bullous pemphigoid.
  • Pemphigus vulgaris.
  • Porphyria cutanea tarda.
  • Dermatitis herpetiformis.
  • Epidermolysis bullosa.

Bullous pemphigoid

General

  • Less serious than pemphigus vulgaris.

Epidemiology:

  • Old people (60-80 year olds).

Clinical

  • Extreme pruritis.

Etiology:

  • Antibodies to BPAG2.

Microscopic

Features:[2]

  • Subepidermal blisters.
  • +/-Lymphocytes.
  • +/-Eosinophils.
  • +/-Neutrophils.

Notes:

  • Epidermis not affect, i.e. non-acantholytic.
  • Linear Ig deposits along basement membrane.

Images:

DDx:

  • Bullous lupus.

Pemphigus vulgaris

General

Classic presentation:

  • Mouth lesions.
  • Non-pruritic.

Treatment:

  • Prednisone then steroid sparing agent.

Epidemiology:

  • Associated with thymoma, myasthenia gravis, malignancy & D-penicillamine (used to Tx Wilson's disease).
  • Middle age.

Microscopic

Features:[5]

  • Suprabasilar blistering.

DDx: Hailey-Hailey disease.

Images:

Notes:

  • Desmoglein 1, desmoglein 3 - abnormal.

Dermatitis herpetiformis

General

Clinical:

  • Pruritis - intense.

Microscopic

Features:[7]

  • Subepidermal blistering.
  • Clusters of neurophils (microabscesses) - at tips of dermal papillae - key feature.
  • Basal cell injury (vacuolization).

Notes:

  • Immunofluorescence - IgA deposits at dermal papillae.

Images:

Porphyria cutanea tarda

General

Etiology:

  • Genetic, autosomal dominant.

Treatment:

  • D/C aggravating substances (see below) - phlebotomy, hydroxychloroquine if phlebotomy contraindicated.

Note:

  • Fits into a larger category of porphyria.

Associations

Medications/substances:

Non-infection chronic conditions:

Infections:

Gross

  • In photoexposed areas subjected to trauma.

Microscopic

Features:[9]

  • Subepidermal vesicles.
  • Thickening of superficial dermal blood vessels.

Images:

Epidermolysis bullosa

  • Inherited, bullae & erosions from slight mechanical trauma.

See also

References

  1. TN07 D21-3.
  2. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1195. ISBN 978-1416031215.
  3. URL: http://dermatology.cdlib.org/94/NYU/Feb2002/8.html. Accessed on: 20 March 2011.
  4. URL: http://missinglink.ucsf.edu/lm/DermatologyGlossary/bullous_pemphigoid.html. Accessed on: 20 March 2011.
  5. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1193. ISBN 978-1416031215.
  6. URL: http://www.dermpedia.org/baby-dermpedia-for-beginners/pemphigus-vulgaris. Accessed on: 20 March 2011.
  7. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1196. ISBN 978-1416031215.
  8. URL: http://dermatology.cdlib.org/94/NYU/Nov2001/9.html. Accessed on: 21 March 2011.
  9. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1197. ISBN 978-1416031215.