Difference between revisions of "AE1/AE3"
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{{ Infobox immunostain | {{ Infobox immunostain | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Small cell lung carcinoma, cytokeratin (AE1 AE3) immunostain (4388394288).jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = AE1/AE3 staining in a [[small cell carcinoma]]. (WC/Yale Rosen) | ||
| Abbrev = | | Abbrev = | ||
| Synonyms = | | Synonyms = | ||
| Similar = [[Z622]] | | Similar = [[Z622]] | ||
| Clones = | | Clones = | ||
| Use = [[unknown primary]] | | Use = [[unknown primary]], confirm carcinoma | ||
| Subspecial = | | Subspecial = | ||
| Pattern = membranous | | Pattern = membranous | ||
Latest revision as of 20:53, 4 January 2019
| AE1/AE3 | |
|---|---|
| Immunostain in short | |
_immunostain_(4388394288).jpg) AE1/AE3 staining in a small cell carcinoma. (WC/Yale Rosen) | |
| Similar stains | Z622 |
| Use | unknown primary, confirm carcinoma |
| Normal staining pattern | membranous |
| Positive | most carcinomas |
| Negative | most lymphomas, most sarcomas |
AE1/AE3 is a common immunostain that marks keratins. It is considered a pankeratin by most.
Positive
- Most or all carcinomas.
Sarcomas:
- Chordoma.
- Desmoplastic small round cell tumour.
- Most epithelioid sarcomas.
- Others.
Negative
- Most lymphomas.
- Most sarcomas.
See also
- CK7.
- CK20.
- EMA.
- Cytokeratin Z622.