Difference between revisions of "AE1/AE3"
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'''AE1/AE3''' is a common [[immunostain]] that marks keratins. It is considered a | {{ Infobox immunostain | ||
| Name = {{PAGENAME}} | |||
| Image = Small cell lung carcinoma, cytokeratin (AE1 AE3) immunostain (4388394288).jpg | |||
| Width = | |||
| Caption = AE1/AE3 staining in a [[small cell carcinoma]]. (WC/Yale Rosen) | |||
| Abbrev = | |||
| Synonyms = | |||
| Similar = [[Z622]] | |||
| Clones = | |||
| Use = [[unknown primary]], confirm carcinoma | |||
| Subspecial = | |||
| Pattern = membranous | |||
| Positive = most carcinomas | |||
| Negative = most lymphomas, most sarcomas | |||
| Other = | |||
}} | |||
'''AE1/AE3''' is a common [[immunostain]] that marks keratins. It is considered a [[pankeratin]] by most. | |||
==Positive== | ==Positive== | ||
| Line 7: | Line 23: | ||
*[[Chordoma]]. | *[[Chordoma]]. | ||
*[[Desmoplastic small round cell tumour]]. | *[[Desmoplastic small round cell tumour]]. | ||
*Most [[epithelioid sarcomas]]. | |||
*Others. | *Others. | ||
| Line 18: | Line 35: | ||
*[[CK20]]. | *[[CK20]]. | ||
*[[EMA]]. | *[[EMA]]. | ||
*[[Cytokeratin Z622]]. | |||
[[Category:Immunohistochemistry]] | [[Category:Immunohistochemistry]] | ||
Latest revision as of 20:53, 4 January 2019
| AE1/AE3 | |
|---|---|
| Immunostain in short | |
_immunostain_(4388394288).jpg) AE1/AE3 staining in a small cell carcinoma. (WC/Yale Rosen) | |
| Similar stains | Z622 |
| Use | unknown primary, confirm carcinoma |
| Normal staining pattern | membranous |
| Positive | most carcinomas |
| Negative | most lymphomas, most sarcomas |
AE1/AE3 is a common immunostain that marks keratins. It is considered a pankeratin by most.
Positive
- Most or all carcinomas.
Sarcomas:
- Chordoma.
- Desmoplastic small round cell tumour.
- Most epithelioid sarcomas.
- Others.
Negative
- Most lymphomas.
- Most sarcomas.
See also
- CK7.
- CK20.
- EMA.
- Cytokeratin Z622.