Difference between revisions of "Cytomegalovirus colitis"

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#redirect [[Colon#Cytomegalovirus_colitis]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = CMV colitis - high mag - cropped.jpg
| Width      =
| Caption    = CMV colitis. [[H&E stain]]. (WC)
| Synonyms  =
| Micro      = enlarged nucleus - classically in endothelial cells, +/-cytoplasmic inclusions
| Subtypes  =
| LMDDx      = [[infectious colitis]]
| Stains    =
| IHC        = CMV +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[colon]]
| Assdx      = +/-[[HIV]] infection
| Syndromes  =
| Clinicalhx = +/-immunosuppression, +/-immune incompetent (e.g. transplant recipients)
| Signs      =
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Cytomegalovirus colitis''' is a type of [[colitis]] caused by [[cytomegalovirus]].
 
==General==
*Uncommon.
*Immunosuppressed population at risk, e.g. transplant recipients, individuals with [[HIV]].
*Typically self-limited in immunocompetent patients.<ref name=pmid21226839>{{Cite journal  | last1 = Kim | first1 = SH. | last2 = Kim | first2 = YS. | last3 = Kim | first3 = HW. | last4 = Yoon | first4 = HE. | last5 = Kim | first5 = HK. | last6 = Kim | first6 = YO. | last7 = Yoon | first7 = SA. | title = A case of cytomegalovirus colitis in an immunocompetent hemodialysis patient. | journal = Hemodial Int | volume = 15 | issue = 2 | pages = 297-300 | month = Apr | year = 2011 | doi = 10.1111/j.1542-4758.2010.00520.x | PMID = 21226839 }}</ref>
 
==Microscopic==
Features:
*Enlarged nucleus - typically in endothelial cells.
**Nucleus classically has peripheral clearing - described as "owl's eye".
**Epithelial cells and lamina propria cells may also be affected.<ref>URL: [http://www.annalsgastro.gr/index.php/annalsgastro/article/view/579 http://www.annalsgastro.gr/index.php/annalsgastro/article/view/579]. Accessed on: 8 February 2016.</ref>
 
DDx:
*[[Infectious colitis]] without a distinctive morphology.
*CMV colitis superimposed on [[inflammatory bowel disease]].
 
===Images===
<gallery>
Image:CMV_colitis_-_intermed_mag.jpg | CMV colitis - intermed. mag. (WC/Nephron)
Image:CMV_colitis_-_high_mag.jpg | CMV colitis - high mag. (WC/Nephron)
Image:CMV colitis vessel high mag.jpg | CMV nuclear inclusions in submucosal vessel - high mag. (WC/MO)
Image:CMV colitis submucosa high mag.jpg | CMV nuclear inclusions in submucosa of colon - high mag. (WC/MO)
</gallery>
www:
*[http://www.flickr.com/photos/lunarcaustic/4615988256/ CMV colitis (flickr.com/lunar caustic)].
*[http://www.flickr.com/photos/lunarcaustic/4615988164/ CMV colitis (flickr.com/lunar caustic)]
*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=000500 CMV colitis (unibas.ch)].
 
==IHC==
*CMV +ve.
**Increases the [[sensitivity]] (compared to H&E alone).<ref name=pmid9170416>{{Cite journal  | last1 = Beaugerie | first1 = L. | last2 = Cywiner-Golenzer | first2 = C. | last3 = Monfort | first3 = L. | last4 = Girard | first4 = PM. | last5 = Carbonnel | first5 = F. | last6 = Ngô | first6 = Y. | last7 = Cosnes | first7 = J. | last8 = Rozenbaum | first8 = W. | last9 = Nicolas | first9 = JC. | title = Definition and diagnosis of cytomegalovirus colitis in patients infected by human immunodeficiency virus. | journal = J Acquir Immune Defic Syndr Hum Retrovirol | volume = 14 | issue = 5 | pages = 423-9 | month = Apr | year = 1997 | doi =  | PMID = 9170416 }}</ref>
 
Others:
*HSV-1.
*HSV-2.
*VZV.
*[[EBV]].
 
===Images===
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354615/figure/f2-ijgm-8-097/ CMV colitis - IHC (nih.gov)].<ref name=pmid25767404>{{Cite journal  | last1 = Harano | first1 = Y. | last2 = Kotajima | first2 = L. | last3 = Arioka | first3 = H. | title = Case of cytomegalovirus colitis in an immunocompetent patient: a rare cause of abdominal pain and diarrhea in the elderly. | journal = Int J Gen Med | volume = 8 | issue =  | pages = 97-100 | month =  | year = 2015 | doi = 10.2147/IJGM.S63771 | PMID = 25767404 }}</ref>
 
==See also==
*[[Colitis]].
*[[Colon]].
 
==References==
{{Reflist|1}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Colon]]

Latest revision as of 17:17, 30 September 2018

Cytomegalovirus colitis
Diagnosis in short

CMV colitis. H&E stain. (WC)
LM enlarged nucleus - classically in endothelial cells, +/-cytoplasmic inclusions
LM DDx infectious colitis
IHC CMV +ve
Site colon
Associated Dx +/-HIV infection
Clinical history +/-immunosuppression, +/-immune incompetent (e.g. transplant recipients)
Prevalence rare

Cytomegalovirus colitis is a type of colitis caused by cytomegalovirus.

General

  • Uncommon.
  • Immunosuppressed population at risk, e.g. transplant recipients, individuals with HIV.
  • Typically self-limited in immunocompetent patients.[1]

Microscopic

Features:

  • Enlarged nucleus - typically in endothelial cells.
    • Nucleus classically has peripheral clearing - described as "owl's eye".
    • Epithelial cells and lamina propria cells may also be affected.[2]

DDx:

Images

  • CMV colitis - intermed. mag. (WC/Nephron)

  • CMV colitis - high mag. (WC/Nephron)

  • CMV nuclear inclusions in submucosal vessel - high mag. (WC/MO)

  • CMV nuclear inclusions in submucosa of colon - high mag. (WC/MO)

www:

IHC

Others:

  • HSV-1.
  • HSV-2.
  • VZV.
  • EBV.

Images

See also

References

  1. ↑ Kim, SH.; Kim, YS.; Kim, HW.; Yoon, HE.; Kim, HK.; Kim, YO.; Yoon, SA. (Apr 2011). "A case of cytomegalovirus colitis in an immunocompetent hemodialysis patient.". Hemodial Int 15 (2): 297-300. doi:10.1111/j.1542-4758.2010.00520.x. PMID 21226839.
  2. ↑ URL: http://www.annalsgastro.gr/index.php/annalsgastro/article/view/579. Accessed on: 8 February 2016.
  3. ↑ Beaugerie, L.; Cywiner-Golenzer, C.; Monfort, L.; Girard, PM.; Carbonnel, F.; Ngô, Y.; Cosnes, J.; Rozenbaum, W. et al. (Apr 1997). "Definition and diagnosis of cytomegalovirus colitis in patients infected by human immunodeficiency virus.". J Acquir Immune Defic Syndr Hum Retrovirol 14 (5): 423-9. PMID 9170416.
  4. ↑ Harano, Y.; Kotajima, L.; Arioka, H. (2015). "Case of cytomegalovirus colitis in an immunocompetent patient: a rare cause of abdominal pain and diarrhea in the elderly.". Int J Gen Med 8: 97-100. doi:10.2147/IJGM.S63771. PMID 25767404.
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