Difference between revisions of "Keratins"
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''' | In pathology, '''keratins''', also '''cytokeratins''', refers to a set of [[immunostain]]s that mark intermediate filaments that are characteristic of epithelial cells, and cancers derived from epithelial cells ([[carcinoma]]s). | ||
''Keratin'' when used in singular may refer to ''[[pankeratin]]''. | ''Keratin'' when used in singular may refer to ''[[pankeratin]]''. | ||
==Classification== | |||
Divided by molecular weight:<ref>[http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]</ref> | |||
*Low molecular weight keratins (LMWK): [[CK7|7]], 8/18, [[CK19|19]], [[CK20|20]]. | |||
*High molecular weight keratins (HWMK): 4, 10, 13, 14, 17. | |||
==Uses== | |||
*CK8 ([[CAM5.2]])<ref name=pmid7508102>{{cite journal |author=Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H |title=The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma |journal=Pathol. Res. Pract. |volume=189 |issue=8 |pages=888–93 |year=1993 |month=September |pmid=7508102 |doi= |url=}}</ref> - used to look for mets from breast cancer in axillary lymph nodes. | |||
*HWMK (e.g. K903<ref>URL: [http://www.aruplab.com/guides/ug/tests/2003978.jsp http://www.aruplab.com/guides/ug/tests/2003978.jsp]. Accessed on: 17 March 2011.</ref>) - [[squamous cell carcinoma]]. | |||
==Sarcomas and keratins== | |||
*Most sarcomas are cytokeratin negative. | |||
Classic exceptions: | |||
*[[Angiosarcoma]], epithelioid. | |||
*[[Synovial sarcoma]]. | |||
*[[Chordoma]]. | |||
*[[Desmoplastic small round cell tumour]]. | |||
*[[Epithelioid sarcoma]]. | |||
Others: | |||
*[[Leiomyosarcoma]]. | |||
==See also== | ==See also== | ||
*[[Immunohistochemistry]]. | *[[Immunohistochemistry]]. | ||
*[[Pankeratin]]. | *[[Pankeratin]]. | ||
==References== | |||
{{Reflist|1}} | |||
[[Category:Immunohistochemistry]] | [[Category:Immunohistochemistry]] | ||
Latest revision as of 09:59, 22 August 2018
In pathology, keratins, also cytokeratins, refers to a set of immunostains that mark intermediate filaments that are characteristic of epithelial cells, and cancers derived from epithelial cells (carcinomas).
Keratin when used in singular may refer to pankeratin.
Classification
Divided by molecular weight:[1]
- Low molecular weight keratins (LMWK): 7, 8/18, 19, 20.
- High molecular weight keratins (HWMK): 4, 10, 13, 14, 17.
Uses
- CK8 (CAM5.2)[2] - used to look for mets from breast cancer in axillary lymph nodes.
- HWMK (e.g. K903[3]) - squamous cell carcinoma.
Sarcomas and keratins
- Most sarcomas are cytokeratin negative.
Classic exceptions:
- Angiosarcoma, epithelioid.
- Synovial sarcoma.
- Chordoma.
- Desmoplastic small round cell tumour.
- Epithelioid sarcoma.
Others:
See also
References
- ↑ http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm
- ↑ Murata T, Nakashima Y, Takeuchi M, Sueishi K, Inomata H (September 1993). "The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma". Pathol. Res. Pract. 189 (8): 888–93. PMID 7508102.
- ↑ URL: http://www.aruplab.com/guides/ug/tests/2003978.jsp. Accessed on: 17 March 2011.