Difference between revisions of "Cutaneous T-cell lymphoma"

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#redirect [[Dermatologic_neoplasms#Cutaneous_T-cell_lymphoma]]
'''Cutaneous_T-cell lymphoma''', abbreviated '''CTCL''', is a malignant [[dermatologic neoplasms|neoplasm that arises in the skin]].
 
==General==
*''Mycosis fungoides'' - is a subtype (???).
*CTCL is more common than cutaneous B-cell lymphoma (CBCL).<ref>URL: [http://emedicine.medscape.com/article/1099540-overview http://emedicine.medscape.com/article/1099540-overview]. Accessed on: 24 August 2010.</ref><ref>URL: [http://emedicine.medscape.com/article/1098342-overview http://emedicine.medscape.com/article/1098342-overview]. Accessed on: 24 August 2010.</ref>
 
Stages - like [[Kaposi sarcoma]]:
*Patch.
*Plaque.
*Nodular.
 
==Microscopic==
*Atypical lymphocytes:
**Have folded "cerebriform" nuclei; ''Sezary-Lutzner cells''.<ref name=Ref_Klatt385>{{Ref Klatt|385}}</ref>
*Grouping:
**Nests in the epidermis - known as "Pautrier microabscesses".
**Single lymphocytes in epidermis - without accompanying edema.
**Short linear arrays of lymphocytes along the basal layer of the epidermis; "epidermotropism".<ref name=Ref_Klatt385>{{Ref Klatt|385}}</ref>
 
DDx:
*[[Lymphomatoid papulosis]].
 
===Images===
<gallery>
Image:Cutaneous_T-cell_lymphoma_-_very_high_mag.jpg | CTCL - very high mag. (WC/Nephron)
Image:Cutaneous_T-cell_lymphoma_-_intermed_mag.jpg | CTCL - intermed. mag. (WC/Nephron)
</gallery>
www:
*[http://www.jci.org/articles/view/24826/figure/2 CTCL (jci.org)].
*[http://www.mdconsult.com/das/book/body/199872830-2/0/1709/I4-u1.0-B978-0-443-06694-8..50117-2--f2.fig CTCL (mdconsult.com)].
 
==IHC==
Key stain:
*CD4 +ve.<ref>{{Ref PBoD8|1185}}</ref>
 
Other stains:
*CD3 +ve.
*CD8 -ve.
*CD20 -ve (to r/o significant B cell population).
*CD30 -ve.
*CD5 +ve.
*CD7 -ve (often lost first in T cell lymphomas).
*Ki-67 high.
*CD56 -ve.
 
==See also==
*[[Dermatologic neoplasms]]
*[[Lymphoma]].
 
==References==
{{Reflist|1}}
 
[[Category:Dermatopathology]]
[[Category:Hematopathology]]

Revision as of 22:19, 6 December 2016

Cutaneous_T-cell lymphoma, abbreviated CTCL, is a malignant neoplasm that arises in the skin.

General

  • Mycosis fungoides - is a subtype (???).
  • CTCL is more common than cutaneous B-cell lymphoma (CBCL).[1][2]

Stages - like Kaposi sarcoma:

  • Patch.
  • Plaque.
  • Nodular.

Microscopic

  • Atypical lymphocytes:
    • Have folded "cerebriform" nuclei; Sezary-Lutzner cells.[3]
  • Grouping:
    • Nests in the epidermis - known as "Pautrier microabscesses".
    • Single lymphocytes in epidermis - without accompanying edema.
    • Short linear arrays of lymphocytes along the basal layer of the epidermis; "epidermotropism".[3]

DDx:

Images

  • CTCL - very high mag. (WC/Nephron)

  • CTCL - intermed. mag. (WC/Nephron)

www:

IHC

Key stain:

Other stains:

  • CD3 +ve.
  • CD8 -ve.
  • CD20 -ve (to r/o significant B cell population).
  • CD30 -ve.
  • CD5 +ve.
  • CD7 -ve (often lost first in T cell lymphomas).
  • Ki-67 high.
  • CD56 -ve.

See also

References

  1. ↑ URL: http://emedicine.medscape.com/article/1099540-overview. Accessed on: 24 August 2010.
  2. ↑ URL: http://emedicine.medscape.com/article/1098342-overview. Accessed on: 24 August 2010.
  3. ↑ 3.0 3.1 Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 385. ISBN 978-1416002741.
  4. ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1185. ISBN 978-1416031215.
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