Difference between revisions of "Atypical lobular hyperplasia"
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'''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized cellular proliferation and cellular dyscohesion. | '''Atypical lobular hyperplasia''', abbreviated '''ALH''', a pre-malignant change in the [[breast]] characterized by cellular proliferation and cellular dyscohesion. | ||
It can be seen as the precursor to [[lobular carcinoma in situ]], the precursor of [[lobular carcinoma]]. | It can be seen as the precursor to [[lobular carcinoma in situ]], the precursor of [[lobular carcinoma]]. | ||
Revision as of 22:03, 28 November 2016
Atypical lobular hyperplasia, abbreviated ALH, a pre-malignant change in the breast characterized by cellular proliferation and cellular dyscohesion.
It can be seen as the precursor to lobular carcinoma in situ, the precursor of lobular carcinoma.
General
- May occur with ductal involvement by cells of atypical lobular hyperplasia (abbreviated DIALH).[1]
- ALH with DIALH has a risk of developing breast cancer that is similar to LCIS.
Microscopic
Features:
- Extent criterium: <50% of terminal duct lobular unit (TDLU) is involved.
- See lobular carcinoma in situ for details.
DDx:
IHC
- E-cadherin -ve or incomplete membrane staining.