Difference between revisions of "Giant cell lesions"
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[[Image:Giant cell tumour of bone - very high mag.jpg|thumb|250px|[[Micrograph]] showing giant cells in a [[giant cell tumour of bone]]. [[H&E stain]].]] | |||
'''Giant cell lesions''' appear from time to time. | '''Giant cell lesions''' appear from time to time. | ||
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*True neoplasms: | *True neoplasms: | ||
**[[Giant cell tumour of bone]]. | **[[Giant cell tumour of bone]]. | ||
**Giant cell tumour of soft tissue. | **Giant cell tumour of soft tissue (peripheral giant cell granuloma). (???) | ||
**Giant cell tumour of the jaw. | **Giant cell tumour of the jaw ([[central giant cell granuloma]]). (???) | ||
**Giant cell tumour of the tendon sheath. | **[[Giant cell tumour of the tendon sheath]]. | ||
**[[Undifferentiated pleomorphic sarcoma]] with giant cells. | **[[Undifferentiated pleomorphic sarcoma]] with giant cells. | ||
**[[Osteosarcoma]] with giant cells. | **[[Osteosarcoma]] with giant cells. | ||
**[[Aneurysmal bone cyst]] | |||
***[[Giant cell reparative granuloma]] ([[AKA]] solid aneurysmal bone cyst<ref name=pmid22285042>{{Cite journal | last1 = Pan | first1 = Z. | last2 = Sanger | first2 = WG. | last3 = Bridge | first3 = JA. | last4 = Hunter | first4 = WJ. | last5 = Siegal | first5 = GP. | last6 = Wei | first6 = S. | title = A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst). | journal = Hum Pathol | volume = | issue = | pages = | month = Jan | year = 2012 | doi = 10.1016/j.humpath.2011.10.003 | PMID = 22285042 }}</ref>). | |||
*Non-neoplastic: | *Non-neoplastic: | ||
**[[Brown tumour]]. | **[[Brown tumour]]. | ||
*Granulomatous disease: | *Granulomatous disease: | ||
**[[Sarcoidosis]]. | **[[Sarcoidosis]]. | ||
**Other granulomatous disease. | **Other [[granuloma|granulomatous]] disease. | ||
***Foreign body giant cells. | |||
*Other: | |||
**[[Syncytiotrophoblasts]]: | |||
***[[Choriocarcinoma]]. | |||
***May be seen in [[seminoma]]/[[germinoma]].<ref name=pmid157614>{{Cite journal | last1 = Hedinger | first1 = C. | last2 = von Hochstetter | first2 = AR. | last3 = Egloff | first3 = B. | title = Seminoma with syncytiotrophoblastic giant cells. A special form of seminoma. | journal = Virchows Arch A Pathol Anat Histol | volume = 383 | issue = 1 | pages = 59-67 | month = Jul | year = 1979 | doi = | PMID = 157614 }}</ref><ref name=pmid6542213>{{Cite journal | last1 = Drut | first1 = R. | last2 = Jones | first2 = MC. | title = Germinoma of the pineal body with syncytiotrophoblastic giant cells. | journal = Pediatr Pathol | volume = 2 | issue = 1 | pages = 65-70 | month = | year = 1984 | doi = | PMID = 6542213 }}</ref> | |||
**[[Malignant melanoma]]. | |||
**"[[Giant cell cystitis]]". | |||
**Others. | |||
==See also== | ==See also== | ||
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*[[Giant cells]]. | *[[Giant cells]]. | ||
*[[GCT]] - an abbreviation used for ''giant cell tumour'' and other tumours. | *[[GCT]] - an abbreviation used for ''giant cell tumour'' and other tumours. | ||
*[[Nuclear pleomorphism]]. | |||
==References== | ==References== | ||
Latest revision as of 21:43, 2 November 2016
Giant cell lesions appear from time to time.
The DDx is large:[1]
- True neoplasms:
- Giant cell tumour of bone.
- Giant cell tumour of soft tissue (peripheral giant cell granuloma). (???)
- Giant cell tumour of the jaw (central giant cell granuloma). (???)
- Giant cell tumour of the tendon sheath.
- Undifferentiated pleomorphic sarcoma with giant cells.
- Osteosarcoma with giant cells.
- Aneurysmal bone cyst
- Giant cell reparative granuloma (AKA solid aneurysmal bone cyst[2]).
- Non-neoplastic:
- Granulomatous disease:
- Sarcoidosis.
- Other granulomatous disease.
- Foreign body giant cells.
- Other:
- Syncytiotrophoblasts:
- Choriocarcinoma.
- May be seen in seminoma/germinoma.[3][4]
- Malignant melanoma.
- "Giant cell cystitis".
- Others.
- Syncytiotrophoblasts:
See also
- Bone.
- Giant cells.
- GCT - an abbreviation used for giant cell tumour and other tumours.
- Nuclear pleomorphism.
References
- ↑ Salzer-Kuntschik M (1998). "[Differential diagnosis of giant cell tumor of bone]" (in German). Verh Dtsch Ges Pathol 82: 154–9. PMID 10095427.
- ↑ Pan, Z.; Sanger, WG.; Bridge, JA.; Hunter, WJ.; Siegal, GP.; Wei, S. (Jan 2012). "A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst).". Hum Pathol. doi:10.1016/j.humpath.2011.10.003. PMID 22285042.
- ↑ Hedinger, C.; von Hochstetter, AR.; Egloff, B. (Jul 1979). "Seminoma with syncytiotrophoblastic giant cells. A special form of seminoma.". Virchows Arch A Pathol Anat Histol 383 (1): 59-67. PMID 157614.
- ↑ Drut, R.; Jones, MC. (1984). "Germinoma of the pineal body with syncytiotrophoblastic giant cells.". Pediatr Pathol 2 (1): 65-70. PMID 6542213.