Difference between revisions of "Bullous diseases"
Jump to navigation
Jump to search
(→Pemphigus vulgaris: wikify) |
|||
| Line 9: | Line 9: | ||
==Bullous pemphigoid== | ==Bullous pemphigoid== | ||
=== | ===General=== | ||
*Less serious the ''pemphigus vulgaris''. | |||
Epidemiology: | |||
*Old people (60-80 year olds). | *Old people (60-80 year olds). | ||
Clinical | |||
*Extreme pruritis. | |||
Etiology: | |||
*Antibodies to BPAG2. | |||
===Microscopic=== | |||
Features:<ref name=Ref_PBoD8_1195>{{Ref PBoD8|1195}}</ref> | |||
*Subepidermal blisters. | |||
*+/-Lymphocytes. | |||
*+/-Eosinophils. | |||
*+/-Neutrophils. | |||
Notes: | |||
*Epidermis not affect, i.e. non-acantholytic. | |||
*Linear Ig deposits along basement membrane. | |||
==Pemphigus vulgaris== | ==Pemphigus vulgaris== | ||
Revision as of 03:47, 21 March 2011
Bullous disease happens. Dermatopathologists help diagnose it.
DDx of bullous disease:[1]
- Bullous pemphigoid.
- Pemphigus vulgaris.
- Porphyria cutanea tarda.
- Dermatitis herpetiformis.
- Epidermolysis bullosa.
Bullous pemphigoid
General
- Less serious the pemphigus vulgaris.
Epidemiology:
- Old people (60-80 year olds).
Clinical
- Extreme pruritis.
Etiology:
- Antibodies to BPAG2.
Microscopic
Features:[2]
- Subepidermal blisters.
- +/-Lymphocytes.
- +/-Eosinophils.
- +/-Neutrophils.
Notes:
- Epidermis not affect, i.e. non-acantholytic.
- Linear Ig deposits along basement membrane.
Pemphigus vulgaris
- AKA pemphigus.
General
Classic presentation:
- Mouth lesions.
- Non-pruritic.
Treatment:
- Prednisone then steroid sparing agent.
Epidemiology:
- Associated with thymoma, myasthenia gravis, malignancy & D-penicillamine (used to Tx Wilson's disease).
- Middle age.
Microscopic
Features:[3]
- Suprabasilar blistering.
DDx: Hailey-Hailey disease.
Images:
Notes:
- Desmoglein 1, desmoglein 3 - abnormal.
Dermatitis herpetiformis
Assoc. with celiac sprue.
Porphyria cutanea tarda
Etiology
- Genetic, autosomal dominant.
Appearance
- Vesicles/bullae in photoexposed areas subjected to trauma.
Associations
Medications/Substances:
Non-infection chronic conditions:
- DM.
Infections:
Treatment
- d/c aggravating substances (listed above), phlebotomy, hydroxychloroquine if phlebotomy contraindicated.
Epidermolysis bullosa
- Inherited, bullae & erosions from slight mechanical trauma.
See also
References
- ↑ TN07 D21-3.
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1195. ISBN 978-1416031215.
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1193. ISBN 978-1416031215.
- ↑ URL: http://www.dermpedia.org/baby-dermpedia-for-beginners/pemphigus-vulgaris. Accessed on: 20 March 2011.