Difference between revisions of "Bullous diseases"
Jump to navigation
Jump to search
m (→See also: sm fix) |
(→Pemphigus vulgaris: more) |
||
| Line 13: | Line 13: | ||
==Pemphigus vulgaris== | ==Pemphigus vulgaris== | ||
=== | ===General=== | ||
Classic presentation: | |||
*Mouth lesions. | *Mouth lesions. | ||
*Non-pruritic. | *Non-pruritic. | ||
Treatment: | |||
*Prednisone then steroid sparing agent. | *Prednisone then steroid sparing agent. | ||
Epidemiology: | |||
* | *Associated with [[thymoma]], myasthenia gravis, malignancy & D-penicillamine (used to Tx [[Wilson's disease]]). | ||
*Middle age. | *Middle age. | ||
===Microscopic=== | |||
Features:<ref>{{Ref PBoD8|1193}}</ref> | |||
*Suprabasilar blistering. | |||
DDx: Hailey-Hailey disease. | DDx: Hailey-Hailey disease. | ||
Revision as of 03:31, 21 March 2011
Bullous disease happens. Dermatopathologists help diagnose it.
DDx of bullous disease:[1]
- Bullous pemphigoid.
- Pemphigus vulgaris.
- Porphyria cutanea tarda.
- Dermatitis herpetiformis.
- Epidermolysis bullosa.
Bullous pemphigoid
Epidemiology
- Old people (60-80 year olds).
Pemphigus vulgaris
General
Classic presentation:
- Mouth lesions.
- Non-pruritic.
Treatment:
- Prednisone then steroid sparing agent.
Epidemiology:
- Associated with thymoma, myasthenia gravis, malignancy & D-penicillamine (used to Tx Wilson's disease).
- Middle age.
Microscopic
Features:[2]
- Suprabasilar blistering.
DDx: Hailey-Hailey disease.
Dermatitis herpetiformis
Assoc. with celiac sprue.
Porphyria cutanea tarda
Etiology
- Genetic, autosomal dominant.
Appearance
- Vesicles/bullae in photoexposed areas subjected to trauma.
Associations
Medications/Substances:
Non-infection chronic conditions:
- DM.
Infections:
Treatment
- d/c aggravating substances (listed above), phlebotomy, hydroxychloroquine if phlebotomy contraindicated.
Epidermolysis bullosa
- Inherited, bullae & erosions from slight mechanical trauma.
See also
References
- ↑ TN07 D21-3.
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1193. ISBN 978-1416031215.