Difference between revisions of "Sclerosing adenosis of the breast"

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'''Sclerosing adenosis of the breast''', also '''sclerosing adenosis''', a benign pathology of the breast associated with an increased risk of malignancy.
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Sclerosing_adenosis_--_high_mag.jpg
| Width      =
| Caption    = Sclerosing_adenosis. [[H&E stain]].
| Synonyms  =
| Micro      = increased numbers of small breast acini with collapsed or slit-like lumens, fibrosis (scleroses) surrounds the acini
| Subtypes  =
| LMDDx      = low-grade [[invasive ductal carcinoma of the breast|ductal carcinoma]], [[tubular adenoma of the breast]], [[adenomyoepithelioma]], breast adenosis
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[breast]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign, increased risk of breast cancer
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Sclerosing adenosis of the breast''', also '''[[sclerosing adenosis]]''', a benign pathology of the breast associated with an increased risk of malignancy.


==General==
==General==
*Can be scary... can look like [[ductal carcinoma]].
*Can look like [[Invasive ductal carcinoma of the breast|ductal carcinoma]].
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular enlargement).
*Derived from ''sclerosing''<ref>URL: [http://dictionary.reference.com/browse/sclerosis http://dictionary.reference.com/browse/sclerosis]. Accessed on: 16 March 2011.</ref> (hardening) and ''adenosis'' (glandular proliferation).
**Think ''scaring'' + ''lotsa glands'' and you're pretty close.
**Think ''scaring'' + ''many glands packed together''.
*Management: follow-up, no further treatment.<ref>URL: [http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions]. Accessed on: 30 April 2012.</ref>
 
Management:  
*Follow-up - no further treatment.<ref>URL: [http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions]. Accessed on: 30 April 2012.</ref>
 
==Microscopic==
==Microscopic==
Features:
Features:
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*Breast adenosis - should have visble lumens.
*Breast adenosis - should have visble lumens.


===Images===
<gallery>
Image: Sclerosing adenosis -- low mag.jpg | SA - low mag. (WC)
Image: Sclerosing adenosis -- intermed mag.jpg | SA - intermed. mag. (WC)
Image: Sclerosing adenosis -- high mag.jpg | SA - high mag. (WC)
Image: Sclerosing adenosis -- very high mag.jpg | SA - very high mag. (WC)
</gallery>
==See also==
==See also==
*[[Breast pathology]].
*[[Breast pathology]].

Latest revision as of 10:31, 8 September 2016

Sclerosing adenosis of the breast
Diagnosis in short

Sclerosing_adenosis. H&E stain.
LM increased numbers of small breast acini with collapsed or slit-like lumens, fibrosis (scleroses) surrounds the acini
LM DDx low-grade ductal carcinoma, tubular adenoma of the breast, adenomyoepithelioma, breast adenosis
Site breast
Prevalence common
Prognosis benign, increased risk of breast cancer

Sclerosing adenosis of the breast, also sclerosing adenosis, a benign pathology of the breast associated with an increased risk of malignancy.

General

  • Can look like ductal carcinoma.
  • Derived from sclerosing[1] (hardening) and adenosis (glandular proliferation).
    • Think scaring + many glands packed together.

Management:

  • Follow-up - no further treatment.[2]

Microscopic

Features:

  • Acini are smaller than usual and there are more of them.
    • Acini often slit-like.
  • Fibrosis (scleroses) - pink on H&E surrounds the acini.

Notes:

  • The acini should:
    • Be in lobular arrangements, i.e. in groups (benign appearance at low power) - key feature.
    • Have two cell layers like well-behaved breast glands do.

DDx:

Images

  • SA - low mag. (WC)

  • SA - intermed. mag. (WC)

  • SA - high mag. (WC)

  • SA - very high mag. (WC)

See also

References

  1. ↑ URL: http://dictionary.reference.com/browse/sclerosis. Accessed on: 16 March 2011.
  2. ↑ URL: http://www.breastcancercare.org.uk/breast-cancer-information/breast-awareness/benign-breast-conditions/sclerosing-lesions. Accessed on: 30 April 2012.
  3. ↑ Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.
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