Difference between revisions of "Papillary adenoma of the kidney"

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#redirect [[Kidney_tumours#Papillary_adenoma_of_the_kidney]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Renal papillary adenoma -- very low mag.jpg
| Width      =
| Caption    = Papillary adenoma. [[H&E stain]].
| Synonyms  = papillary adenoma, renal papillary adenoma
| Micro      = papillae typically with foam cells, +/-psammoma bodies, low [[ISUP nucleolar grade]], ''must'' be <=1.5 cm
| Subtypes  =
| LMDDx      = [[papillary renal cell carcinoma]], [[metanephric adenoma]]
| Stains    =
| IHC        = AMACR +ve
| EM        =
| Molecular  =
| IF        =
| Gross      = typically subcapsular location
| Grossing  =
| Site      = [[kidney]] - see ''[[kidney tumours]]''
| Assdx      = often seen with [[papillary renal cell carcinoma]]
| Syndromes  =
| Clinicalhx = often an incidental finding
| Signs      =
| Symptoms  =
| Prevalence = common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = other [[renal tumours]]
| Tx        = observation
}}
'''Papillary adenoma of the kidney''', also '''renal papillary adenoma''', is a benign [[kidney tumours|kidney tumour]] related to [[papillary renal cell carcinoma]].


==General==
*Benign.
*Considered a precursor for ''[[papillary renal cell carcinoma]]'' (PaRCC).<ref name=pmid17056094>{{Cite journal  | last1 = Wang | first1 = KL. | last2 = Weinrach | first2 = DM. | last3 = Luan | first3 = C. | last4 = Han | first4 = M. | last5 = Lin | first5 = F. | last6 = Teh | first6 = BT. | last7 = Yang | first7 = XJ. | title = Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma. | journal = Hum Pathol | volume = 38 | issue = 2 | pages = 239-46 | month = Feb | year = 2007 | doi = 10.1016/j.humpath.2006.07.016 | PMID = 17056094 }}</ref>
**Stains like PaRCC.
**Found with an increased frequency within the content of PaRCC.
Note:
*In the kidney, the concept of ''[[adenoma]]'' only exists for papillary lesions that are [[papillary RCC]]-like. Small lesions that are [[chromophobe RCC]]-like or [[clear cell RCC]]-like are carcinomas.<ref name=pmid18846240/>
==Gross==
*Cortical kidney lesion.
**Usually subcapsular.
==Microscopic==
Features:
#Histomorphology of ''[[papillary renal cell carcinoma]]'' with low [[ISUP nucleolar grade]] (grade 1 or 2).
#''Must'' be <=1.5 cm as per 2016 WHO classification.<ref name=pmid26935559>{{Cite journal  | last1 = Moch | first1 = H. | last2 = Cubilla | first2 = AL. | last3 = Humphrey | first3 = PA. | last4 = Reuter | first4 = VE. | last5 = Ulbright | first5 = TM. | title = The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. | journal = Eur Urol | volume =  | issue =  | pages =  | month = Feb | year = 2016 | doi = 10.1016/j.eururo.2016.02.029 | PMID = 26935559 }}</ref>
#*[[Diagnostic size cutoff]] - larger lesions are ''papillary renal cell carcinoma''.
Note:
*The size cut-off used to be <=0.5 cm.<ref name=pmid26935559/><ref name=Ref_GUP288>{{Ref GUP|288}}</ref><ref name=pmid18846240>{{Cite journal  | last1 = Algaba | first1 = F. | title = Renal adenomas: pathological differential diagnosis with malignant tumors. | journal = Adv Urol | volume =  | issue =  | pages = 974848 | month =  | year = 2008 | doi = 10.1155/2008/974848 | PMID = 18846240 | PMC = 2563151 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563151/?tool=pubmed }}</ref>
DDx:
*[[Papillary renal cell carcinoma]].
*[[Metanephric adenoma]].
===Images===
<gallery>
Image: Renal papillary adenoma -- very low mag.jpg | PA - very low mag.
Image: Renal papillary adenoma -- low mag.jpg | PA - low mag.
Image: Renal papillary adenoma -- intermed mag.jpg | PA - intermed. mag.
Image: Renal papillary adenoma - alt -- intermed mag.jpg | PA - intermed. mag.
Image: Renal papillary adenoma -- high mag.jpg | PA - high mag.
</gallery>
www:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563151/figure/fig2/ Renal papillary adenoma (nih.gov)].<ref name=pmid18846240/>
==IHC==
*CK7 +ve.
*AMACR +ve.<ref name=pmid17056094/>
==See also==
*[[Kidney tumours]].
==References==
{{Reflist|2}}
[[Category:Kidney tumours]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 12:57, 23 June 2016

Papillary adenoma of the kidney
Diagnosis in short

Papillary adenoma. H&E stain.
Synonyms papillary adenoma, renal papillary adenoma
LM papillae typically with foam cells, +/-psammoma bodies, low ISUP nucleolar grade, must be <=1.5 cm
LM DDx papillary renal cell carcinoma, metanephric adenoma
IHC AMACR +ve
Gross typically subcapsular location
Site kidney - see kidney tumours
Associated Dx often seen with papillary renal cell carcinoma
Clinical history often an incidental finding
Prevalence common
Prognosis benign
Clin. DDx other renal tumours
Treatment observation

Papillary adenoma of the kidney, also renal papillary adenoma, is a benign kidney tumour related to papillary renal cell carcinoma.

General

Note:

Gross

  • Cortical kidney lesion.
    • Usually subcapsular.

Microscopic

Features:

  1. Histomorphology of papillary renal cell carcinoma with low ISUP nucleolar grade (grade 1 or 2).
  2. Must be <=1.5 cm as per 2016 WHO classification.[3]

Note:

  • The size cut-off used to be <=0.5 cm.[3][4][2]

DDx:

Images

  • PA - very low mag.

  • PA - low mag.

  • PA - intermed. mag.

  • PA - intermed. mag.

  • PA - high mag.

www:

IHC

  • CK7 +ve.
  • AMACR +ve.[1]

See also

References

  1. ↑ 1.0 1.1 Wang, KL.; Weinrach, DM.; Luan, C.; Han, M.; Lin, F.; Teh, BT.; Yang, XJ. (Feb 2007). "Renal papillary adenoma--a putative precursor of papillary renal cell carcinoma.". Hum Pathol 38 (2): 239-46. doi:10.1016/j.humpath.2006.07.016. PMID 17056094.
  2. ↑ 2.0 2.1 2.2 Algaba, F. (2008). "Renal adenomas: pathological differential diagnosis with malignant tumors.". Adv Urol: 974848. doi:10.1155/2008/974848. PMC 2563151. PMID 18846240. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563151/.
  3. ↑ 3.0 3.1 Moch, H.; Cubilla, AL.; Humphrey, PA.; Reuter, VE.; Ulbright, TM. (Feb 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.". Eur Urol. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.
  4. ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 288. ISBN 978-0443066771.
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