Difference between revisions of "Pleural plaque"

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#redirect [[Pleural plaques]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Pleural plaque - 2 -- very low mag.jpg
| Width      =
| Caption    = [[Micrograph]] of a pleural plaque. [[H&E stain]]. (WC/Nephron)
| Synonyms  =
| Micro      = hyaline (fibrosis) material +/-[[calcification]]s
| Subtypes  =
| LMDDx      = [[fibrosing pleuritis‎‎]], [[malignant mesothelioma]] - especially [[desmoplastic mesothelioma]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      = white pleural lesions
| Grossing  =
| Staging    =
| Site      = [[pleura]]
| Assdx      = [[asbestosis]], [[malignant mesothelioma]]
| Syndromes  =
| Clinicalhx = exposure to asbestos
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      = pleural thickening
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = [[malignant mesothelioma]], metastatic [[carcinoma]]
| Tx        =
}}
A '''pleural plaque''' is a benign fibrous thickening of the [[pleura]]. It is strongly associated with asbestos exposure.<ref name=pmid22617814>{{Cite journal  | last1 = Myers | first1 = R. | title = Asbestos-related pleural disease. | journal = Curr Opin Pulm Med | volume = 18 | issue = 4 | pages = 377-81 | month = Jul | year = 2012 | doi = 10.1097/MCP.0b013e328354acfe | PMID = 22617814 }}</ref>
 
==General==
*May be due to other causes.<ref name=pmid17867573>{{Cite journal  | last1 = Clarke | first1 = CC. | last2 = Mowat | first2 = FS. | last3 = Kelsh | first3 = MA. | last4 = Roberts | first4 = MA. | title = Pleural plaques: a review of diagnostic issues and possible nonasbestos factors. | journal = Arch Environ Occup Health | volume = 61 | issue = 4 | pages = 183-92 | month =  | year =  | doi = 10.3200/AEOH.61.4.183-192 | PMID = 17867573 }}</ref>
 
Other asbestos-related pleural disease:<ref name=pmid22617814/>
*Diffuse pleural thickening.
*Benign asbestos-related [[pleural effusion]]s (BAPEs).
*[[Malignant mesothelioma]].
 
==Gross==
*Thickened (or calcified) plaques.<ref name=pmid17867573/>
*White.
 
DDx:
*[[Metastatic]] carcinoma.
 
===Images===
<gallery>
Image:Asbestosis_-_Fibrous_pleural_plaque_(7468458430).jpg | Fibrous pleural plaque. (WC/Rosen)
</gallery>
*[http://library.med.utah.edu/WebPath/LUNGHTML/LUNG083.html Pleural plaque (utah.edu)].
 
==Microscopic==
Features:<ref name=pmid5556121/>
*Hyaline material +/- [[calcification]].
 
Notes:
*Usually associated with asbestosis fibres in the [[lung]] (85% of cases).<ref name=pmid5556121>{{Cite journal  | last1 = Roberts | first1 = GH. | title = The pathology of parietal pleural plaques. | journal = J Clin Pathol | volume = 24 | issue = 4 | pages = 348-53 | month = May | year = 1971 | doi =  | PMID = 5556121 }}</ref>
**Plaque burden seems to be associated with the number asbestos bodies found; many plaques... suggest many asbestosis bodies.
 
DDx:
*[[Fibrosing pleuritis‎‎]].
*[[Desmoplastic mesothelioma]].
 
===Images===
<gallery>
Image: Pleural plaque -- extremely low mag.jpg | PP - extremely low mag. (WC)
Image: Pleural plaque -- very low mag.jpg | PP - very low mag. (WC)
Image: Pleural plaque -- low mag.jpg | PP - low mag. (WC)
Image: Pleural plaque -- intermed mag.jpg | PP - intermed. mag. (WC)
Image: Pleural plaque -- high mag.jpg | PP - high mag. (WC)
 
Image: Pleural plaque - 2 -- very low mag.jpg | PP - low mag. (WC)
Image: Pleural plaque - 2a -- very low mag.jpg | PP - low mag. (WC)
Image: Pleural plaque - 2 -- low mag.jpg | PP - low mag. (WC)
Image: Pleural plaque - 2 -- intermed mag.jpg | PP - intermed. mag. (WC)
Image: Pleural plaque - 2a -- intermed mag.jpg | PP - intermed. mag. (WC)
</gallery>
====www====
*[http://library.med.utah.edu/WebPath/LUNGHTML/LUNG102.html Pleural plaque (utah.edu)].
 
==Sign out==
<pre>
Pleura, Left Lung, Biopsy:
- Fibrous pleuritis/pleural plaque (fibrous tissue with mild chronic inflammation
  and calcifications).
- NEGATIVE for evidence of malignancy.
</pre>
 
==See also==
*[[Asbestosis]] - lung has fibrosis.
*[[Malignant mesothelioma]].
*[[Ferruginous bodies]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Pulmonary pathology]]

Latest revision as of 12:37, 14 June 2016

Pleural plaque
Diagnosis in short

Micrograph of a pleural plaque. H&E stain. (WC/Nephron)
LM hyaline (fibrosis) material +/-calcifications
LM DDx fibrosing pleuritis‎‎, malignant mesothelioma - especially desmoplastic mesothelioma
Gross white pleural lesions
Site pleura
Associated Dx asbestosis, malignant mesothelioma
Clinical history exposure to asbestos
Prevalence uncommon
Radiology pleural thickening
Prognosis benign
Clin. DDx malignant mesothelioma, metastatic carcinoma

A pleural plaque is a benign fibrous thickening of the pleura. It is strongly associated with asbestos exposure.[1]

General

  • May be due to other causes.[2]

Other asbestos-related pleural disease:[1]

Gross

  • Thickened (or calcified) plaques.[2]
  • White.

DDx:

Images

  • Fibrous pleural plaque. (WC/Rosen)

Microscopic

Features:[3]

Notes:

  • Usually associated with asbestosis fibres in the lung (85% of cases).[3]
    • Plaque burden seems to be associated with the number asbestos bodies found; many plaques... suggest many asbestosis bodies.

DDx:

Images

  • PP - extremely low mag. (WC)

  • PP - very low mag. (WC)

  • PP - low mag. (WC)

  • PP - intermed. mag. (WC)

  • PP - high mag. (WC)

  • PP - low mag. (WC)

  • PP - low mag. (WC)

  • PP - low mag. (WC)

  • PP - intermed. mag. (WC)

  • PP - intermed. mag. (WC)

www

Sign out

Pleura, Left Lung, Biopsy:
- Fibrous pleuritis/pleural plaque (fibrous tissue with mild chronic inflammation 
  and calcifications).
- NEGATIVE for evidence of malignancy.

See also

References

  1. ↑ 1.0 1.1 Myers, R. (Jul 2012). "Asbestos-related pleural disease.". Curr Opin Pulm Med 18 (4): 377-81. doi:10.1097/MCP.0b013e328354acfe. PMID 22617814.
  2. ↑ 2.0 2.1 Clarke, CC.; Mowat, FS.; Kelsh, MA.; Roberts, MA.. "Pleural plaques: a review of diagnostic issues and possible nonasbestos factors.". Arch Environ Occup Health 61 (4): 183-92. doi:10.3200/AEOH.61.4.183-192. PMID 17867573.
  3. ↑ 3.0 3.1 Roberts, GH. (May 1971). "The pathology of parietal pleural plaques.". J Clin Pathol 24 (4): 348-53. PMID 5556121.
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