Difference between revisions of "Hemolytic uremic syndrome"

From Libre Pathology
Jump to navigation Jump to search
(+omentum)
Line 11: Line 11:


==Pathology==
==Pathology==
In children partial omentectomies are done in the placement of peritoneal catheters (for dialysis), to avoid subsequent blockage.<ref name=pmid7838254>{{cite journal |author=Pumford N, Cassey J, Uttley WS |title=Omentectomy with peritoneal catheter placement in acute renal failure |journal=Nephron |volume=68 |issue=3 |pages=327–8 |year=1994 |pmid=7838254 |doi= |url=}}</ref>
In children partial omentectomies are done during the placement of peritoneal catheters, to avoid subsequent (catheter) blockage.<ref name=pmid7838254>{{cite journal |author=Pumford N, Cassey J, Uttley WS |title=Omentectomy with peritoneal catheter placement in acute renal failure |journal=Nephron |volume=68 |issue=3 |pages=327–8 |year=1994 |pmid=7838254 |doi= |url=}}</ref>


===Microscopic===
===Microscopic===

Revision as of 19:07, 16 March 2011

Hemolytic uremic syndrome, abbreviated HUS, is the triad of:[1]

  • Microangiopathic hemolytic anemia.
    • Microangiopathic = disease affecting small blood vessels.[2]
  • Thrombocytopenia = low platelet count.
  • Acute renal failure.

Etiology

  • Rare (uncooked) hamburger.
  • E. coli serotype O157:H7.
    • Verotoxins from E. coli O157:H7 --> endothelial injury.[3]

Pathology

In children partial omentectomies are done during the placement of peritoneal catheters, to avoid subsequent (catheter) blockage.[4]

Microscopic

Features:

  • Mesothelial-lined fibroadipose tissue.

Relation to thrombotic thrombocytopenic purpura (TTP)

  • TTP is the main (clinical) DDx of HUS.
    • It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
  • Both are classified as thrombotic microangiopathies.[5]

See also

References

  1. ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
  2. ↑ URL: http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm. Accessed on: 9 September 2010.
  3. ↑ Petruzziello TN, Mawji IA, Khan M, Marsden PA (February 2009). "Verotoxin biology: molecular events in vascular endothelial injury". Kidney Int. Suppl. (112): S17–9. doi:10.1038/ki.2008.612. PMID 19180125.
  4. ↑ Pumford N, Cassey J, Uttley WS (1994). "Omentectomy with peritoneal catheter placement in acute renal failure". Nephron 68 (3): 327–8. PMID 7838254.
  5. ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
Retrieved from "https://librepathology.org/w/index.php?title=Hemolytic_uremic_syndrome&oldid=4494"