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| '''Anal intraepithelial neoplasia''', abbreviated '''AIN''', the precursor of [[anal squamous cell carcinoma]].
| | #redirect [[Anal intraepithelial neoplasia]] |
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| ==General==
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| *Precursor lesion of anal [[squamous cell carcinoma]].
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| *Usually [[HPV]] associated.
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| **May be prevented by HPV vaccine.
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| ==Microscopic==
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| DDx:
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| *[[Anal squamous cell carcinoma]].
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| ===Grading===
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| AIN is graded much like [[cervix|cervical intraepithelial neoplasia]]:
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| *High-grade anal intraepithelial neoplasia (HGAIN).
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| *Low-grade anal intraepithelial neoplasia (LGAIN).
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| ==Sign out==
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| <pre>
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| ANAL CANAL, RIGHT UPPER QUADRANT, BIOPSY:
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| - LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CONDYLOMA ACUMINATUM-LIKE).
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| </pre>
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| <pre>
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| ANAL CANAL, LEFT UPPER QUADRANT, BIOPSY:
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| - LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION.
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| - RECTAL MUCOSA WITHIN NORMAL LIMITS.
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| </pre>
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| <pre>
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| SKIN LESION, PERIANAL, BIOPSY:
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| - ANAL INTRAEPITHELIAL NEOPLASIA 3 (SEVERE DYSPLASIA), WARTY-TYPE.
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| - MARGIN POSITIVE FOR ANAL INTRAEPITHELIAL NEOPLASIA 3.
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| </pre>
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| ===Micro===
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| There is dysplastic squamous epithelium with coarse chromatin, nuclear hyperchromasia,
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| nuclear enlargement, irregular nuclear membranes, and an increase nuclear-to-cytoplasmic
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| ratio. Mitotic activity is abundant. Several atypical mitoses are identified.
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| The dysplastic squamous epithelium shows minimal maturation toward the surface (AIN 3). A
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| sizable portion of the lesion show some maturation to the surface (AIN 2).
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| Inflammation at the dermal-epidermal interface is minimal and the dermal-epidermal
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| interface is well-demarcated. Focal ulceration is present.
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| The margin of the biopsy has severely dysplastic epithelium (AIN 3).
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| ==See also==
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| *[[Anus]].
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| *[[LSIL]].
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| *[[HSIL]].
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| ==References==
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| {{Reflist|1}}
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| [[Category:Diagnosis]]
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| [[Category:Anus]].
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