Difference between revisions of "Small bowel pseudomelanosis"
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'''Pseudomelanosis duodeni''' is benign change of the [[duodenum]] that mimics melanin deposition. | |||
==General== | |||
*Rare. | |||
*Consists of iron and lipofuscin.<ref name=pmid2458404>{{Cite journal | last1 = Lin | first1 = HJ. | last2 = Tsay | first2 = SH. | last3 = Chiang | first3 = H. | last4 = Tsai | first4 = YT. | last5 = Lee | first5 = SD. | last6 = Yeh | first6 = YS. | last7 = Lo | first7 = GH. | title = Pseudomelanosis duodeni. Case report and review of literature. | journal = J Clin Gastroenterol | volume = 10 | issue = 2 | pages = 155-9 | month = Apr | year = 1988 | doi = | PMID = 2458404 }} | |||
</ref> | |||
Associations:<ref name=pmid18253910/> | |||
*[[Hypertension]] ~90% of cases. | |||
*Iron supplementation ~75% of cases. | |||
*End-stage renal disease ~60% of cases. | |||
Note: | |||
*The associations are different than for ''[[melanosis coli]]''. | |||
==Gross/endoscopic== | |||
*Dark spots ~35% of cases.<ref name=pmid18253910>{{Cite journal | last1 = Giusto | first1 = D. | last2 = Jakate | first2 = S. | title = Pseudomelanosis duodeni: associated with multiple clinical conditions and unpredictable iron stainability - a case series. | journal = Endoscopy | volume = 40 | issue = 2 | pages = 165-7 | month = Feb | year = 2008 | doi = 10.1055/s-2007-995472 | PMID = 18253910 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Dark pigment in the lamina propria macrophages. | |||
Images: | |||
*[http://path.upmc.edu/cases/case616.html Pseudomelanosis duodeni - several images (upmc.edu)]. | |||
==Stains== | |||
*Prussian blue +ve ~80% of cases.<ref name=pmid18253910/> | |||
==See also== | |||
*[[Pseudomelanosis coli]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Gastrointestinal pathology]] | |||
Revision as of 22:26, 8 March 2016
Pseudomelanosis duodeni is benign change of the duodenum that mimics melanin deposition.
General
- Rare.
- Consists of iron and lipofuscin.[1]
Associations:[2]
- Hypertension ~90% of cases.
- Iron supplementation ~75% of cases.
- End-stage renal disease ~60% of cases.
Note:
- The associations are different than for melanosis coli.
Gross/endoscopic
- Dark spots ~35% of cases.[2]
Microscopic
Features:
- Dark pigment in the lamina propria macrophages.
Images:
Stains
- Prussian blue +ve ~80% of cases.[2]
See also
References
- ↑ Lin, HJ.; Tsay, SH.; Chiang, H.; Tsai, YT.; Lee, SD.; Yeh, YS.; Lo, GH. (Apr 1988). "Pseudomelanosis duodeni. Case report and review of literature.". J Clin Gastroenterol 10 (2): 155-9. PMID 2458404.
- ↑ 2.0 2.1 2.2 Giusto, D.; Jakate, S. (Feb 2008). "Pseudomelanosis duodeni: associated with multiple clinical conditions and unpredictable iron stainability - a case series.". Endoscopy 40 (2): 165-7. doi:10.1055/s-2007-995472. PMID 18253910.