Difference between revisions of "Case 120"
Jump to navigation
Jump to search
Intermediate magnification. H&E stain.
Jensflorian (talk | contribs) (case 120 - heavy) |
Jensflorian (talk | contribs) (case 121) |
||
| Line 1: | Line 1: | ||
===Provided clinical history=== | ===Provided clinical history=== | ||
43 year old female with thoracic lesion . | |||
===Site=== | ===Site=== | ||
Exision of dura-based, calcified tumor. | |||
===Primary image=== | ===Primary image=== | ||
[[Image: | [[Image:NP_psammomatous_meningioma_0001.jpg|500px|link=|center|]] | ||
<center>Intermediate magnification. [[H&E stain]].</center> | <center>Intermediate magnification. [[H&E stain]].</center> | ||
{{hidden|Intermediate magnification|[[Image: | {{hidden|Intermediate magnification|[[Image:NP_psammomatous_meningioma_0002.jpg|500px|link=|center|]] | ||
<center>Intermediate magnification. [[H&E stain]].</center>}} | <center>Intermediate magnification. [[H&E stain]].</center>}} | ||
{{hidden|High magnification|[[Image: | {{hidden|High magnification|[[Image:NP_psammomatous_meningioma_0003.jpg.jpg |500px|link=|center|]] | ||
<center>Intermediate magnification. [[H&E stain]].</center>}} | <center>Intermediate magnification. [[H&E stain]].</center>}} | ||
===Differential diagnosis=== | ===Differential diagnosis=== | ||
{{hidden|Differential diagnosis|<center> | {{hidden|Differential diagnosis|<center>Lesions with [[Psammoma bodies]] present.</center>}} | ||
===Additional tests=== | ===Additional tests=== | ||
====More history==== | ====More history==== | ||
{{hidden|More history|<center> | {{hidden|More history|<center>No further information available. The neurosurgeon is currently away.</center>}} | ||
====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center> | {{hidden|Ask a colleague|<center> These round, calcified structures look like [[Psammoma bodies]].</center>}} | ||
====Stains==== | ====Stains==== | ||
| Line 133: | Line 133: | ||
| dog1= | | dog1= | ||
| ebv= | | ebv= | ||
| ema= | | ema= '''POSITIVE''' | ||
| erpr= | | erpr= | ||
| f_viii= | | f_viii= | ||
| Line 143: | Line 143: | ||
| gata3= | | gata3= | ||
| gcdfp= | | gcdfp= | ||
| gfap= ''' | | gfap= '''NEGATIVE''' | ||
| gh= | | gh= | ||
| glucagon= | | glucagon= | ||
| Line 166: | Line 166: | ||
| insulin= | | insulin= | ||
| kappa= | | kappa= | ||
| ki67= ''' | | ki67= '''1%''' | ||
| lambda= | | lambda= | ||
| leu7= | | leu7= | ||
| Line 175: | Line 175: | ||
| lysozyme= | | lysozyme= | ||
| mammogl= | | mammogl= | ||
| map2= ''' | | map2= '''NEGATIVE''' | ||
| mcv= | | mcv= | ||
| melanin_a= '''NEGATIVE''' | | melanin_a= '''NEGATIVE''' | ||
| Line 205: | Line 205: | ||
| psap= | | psap= | ||
| rcc= | | rcc= | ||
| s100= ''' | | s100= '''NEGATIVE''' | ||
| sma= | | sma= | ||
| somatsatin= | | somatsatin= | ||
| stat6= | | stat6= '''NEGATIVE''' | ||
| synapto= '''NEGATIVE''' | | synapto= '''NEGATIVE''' | ||
| tdt= | | tdt= | ||
| Line 257: | Line 257: | ||
| b_cell_clone = | | b_cell_clone = | ||
| bcl2 = | | bcl2 = | ||
| braf = ''' | | braf = '''NO MUTATION''' | ||
| EBV_pcr = | | EBV_pcr = | ||
| egrf = | | egrf = | ||
| h3f3a = | | h3f3a = | ||
| hhv8_pcr = | | hhv8_pcr = | ||
| identity_test = | | identity_test = | ||
| idh1_2 = | | idh1_2 = | ||
| jak2_v617f = | | jak2_v617f = | ||
| kit = | | kit = | ||
| loh_1p19q = | | loh_1p19q = | ||
| t_cell_clone = | | t_cell_clone = | ||
}} | }} | ||
===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center>[[ | {{hidden|Diagnosis|<center>Psammomatous [[meningioma]], WHO grade I</center> | ||
<br> | <br> | ||
Comment: | Comment: It is said, that psammoma bodies represent a process of dystrophic calcification or as an active biologic barrier to tumor spread ultimately leading to degeneration/death of tumor cells. <ref>{{Cite journal | last1 = KEPES | first1 = J. | title = Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas. | journal = J Neuropathol Exp Neurol | volume = 20 | issue = | pages = 255-62 | month = Apr | year = 1961 | doi = | PMID = 13752577 }}</ref> <ref>{{Cite journal | last1 = Das | first1 = DK. | title = Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? | journal = Diagn Cytopathol | volume = 37 | issue = 7 | pages = 534-41 | month = Jul | year = 2009 | doi = 10.1002/dc.21081 | PMID = 19373908 }}</ref> | ||
}} | |||
===Other cases=== | ===Other cases=== | ||
| Line 283: | Line 284: | ||
[[Category:Cases in neuropathology]] | [[Category:Cases in neuropathology]] | ||
[[Category:Cases in neuropathology - | [[Category:Cases in neuropathology - junior]] | ||
[[Category:Cases difficulty | [[Category:Cases difficulty 1]] <!-- difficulty 1-7 -- should roughly correspond to the PGY level --> | ||
Revision as of 09:38, 29 February 2016
Provided clinical history
43 year old female with thoracic lesion .
Site
Exision of dura-based, calcified tumor.
Primary image
Intermediate magnification
|
|---|
 |
High magnification
|
|---|
|
|
Differential diagnosis
Differential diagnosis
|
|---|
|
|
Additional tests
More history
More history
|
|---|
|
|
Ask a colleague
Ask a colleague
|
|---|
|
|
Stains
|
|
|
|
|
|
|---|
IHC
|
|
|
|
|
|
|---|
Molecular testing
Chromosomal translocations
|
|
|
|
|---|
Other molecular tests
|
|
|
|
|---|
Diagnosis
Diagnosis
|
|---|
|
|
Other cases
- ↑ KEPES, J. (Apr 1961). "Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas.". J Neuropathol Exp Neurol 20: 255-62. PMID 13752577.
- ↑ Das, DK. (Jul 2009). "Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor?". Diagn Cytopathol 37 (7): 534-41. doi:10.1002/dc.21081. PMID 19373908.