Difference between revisions of "Retinoblastoma"

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| Caption    = Retinoblastoma. (WC)
| Caption    = Retinoblastoma. (WC)
| Synonyms  =
| Synonyms  =
| Micro      = [[small round cell tumour]]
| Micro      = [[small round cell tumour]], Flexner-Wintersteiner [[rosette]]s
| Subtypes  =
| Subtypes  =
| LMDDx      =
| LMDDx      = retinocytoma, other [[small round cell tumours]]
| Stains    =
| Stains    =
| IHC        =
| IHC        =
Line 13: Line 13:
| Molecular  =
| Molecular  =
| IF        =
| IF        =
| Gross      =
| Gross      = white, solid, friable
| Grossing  =
| Grossing  =
| Staging    =
| Staging    =

Revision as of 03:53, 9 February 2016

Retinoblastoma
Diagnosis in short

Retinoblastoma. (WC)

LM small round cell tumour, Flexner-Wintersteiner rosettes
LM DDx retinocytoma, other small round cell tumours
Gross white, solid, friable
Site eye

Prevalence rare

Retinoblastoma is malignant tumour the of the eye.

General

Gross

  • White, solid.
  • Patterns:
    • Endophytic - grow into the vitreous cavity.
    • Exophytic - grow toward choroid.
    • Mixed - components of endophytic and exophytic.

Note:

  • Tumour is extremely friable.

Image

Microscopic

Features:

  • Small round cell tumour:
    • Scant cytoplasm.
  • Flexner-Wintersteiner rosette - key feature.
    • Rosette with empty centre (donut hole).[2]
  • +/-Homer-Wright rosette.[3]
    • Circular rosette with neuropil at the centre.[2]
  • Mitoses - common.
  • +/-Necrosis.
  • +/-Calcification.

DDx:

  • Retinocytoma (retinoma) - benign counterpart of retinoblastoma.

Notes:

  • DDx of Flexner-Wintersteiner rosette includes:
    • Pineoblastoma.
    • Medulloepithelioma.

Images

www

See also

References

  1. Lohmann D (2010). "Retinoblastoma". Adv. Exp. Med. Biol. 685: 220–7. PMID 20687510.
  2. 2.0 2.1 Wippold FJ, Perry A (March 2006). "Neuropathology for the neuroradiologist: rosettes and pseudorosettes". AJNR Am J Neuroradiol 27 (3): 488–92. PMID 16551982.
  3. WH. 14 March 2011.