Difference between revisions of "Pseudohyperplastic prostatic adenocarcinoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Pseudohyperplastic carcinoma -- high mag.jpg
| Width      =
| Caption    = Pseudohyperplastic carcinoma. [[H&E stain]].
| Synonyms  =
| Micro      = medium to large glands with an atypical morphology (papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation), nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement)
| Subtypes  = subtype of [[prostate carcinoma]]
| LMDDx      = benign prostatic tissue, [[foamy gland carcinoma]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]]
| Staging    = [[prostate cancer staging]]
| Site      = [[prostate gland]] - see ''[[prostate carcinoma]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  = +/-[[PSA]] elevated
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        = see ''[[prostate carcinoma]]''
}}
'''Pseudohyperplastic prostatic adenocarcinoma''', also '''pseudohyperplastic adenocarcinoma''' is an uncommon type of [[prostate carcinoma]] that may mimic benign [[prostate gland|prostate]].
'''Pseudohyperplastic prostatic adenocarcinoma''', also '''pseudohyperplastic adenocarcinoma''' is an uncommon type of [[prostate carcinoma]] that may mimic benign [[prostate gland|prostate]].


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**Papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation.  
**Papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation.  
*Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).
*Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).
Notes:
*Often associated with conventional (acinar) prostate adenocarcinoma.
*Pale abundant cytoplasm - similar to normal prostate.


DDx:
DDx:
*[[Foamy gland carcinoma]] - often lack prominent nucleoli, smaller glands.
*[[Foamy gland carcinoma]] - often lack prominent nucleoli, smaller glands.
*Benign prostatic glands.
*Benign prostatic glands - esp. at low power.


===Images===
===Images===
<gallery>
Image: Pseudohyperplastic carcinoma -- low mag.jpg | PHC - low mag.
Image: Pseudohyperplastic carcinoma -- intermed mag.jpg | PHC - intermed. mag.
Image: Pseudohyperplastic carcinoma -- high mag.jpg | PHC - high mag.
Image: Pseudohyperplastic carcinoma - alt -- intermed mag.jpg | PHC - intermed. mag.
Image: Pseudohyperplastic carcinoma - alt -- high mag.jpg | PHC - high mag.
</gallery>
www:
*[http://www.webpathology.com/image.asp?n=29&Case=23 Pseudohyperplastic adenocarcinoma (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=29&Case=23 Pseudohyperplastic adenocarcinoma (webpathology.com)].
*[http://www.nature.com/modpathol/journal/v17/n3/fig_tab/3800050f13.html Pseudohyperplastic prostatic adenocarcinoma (nature.com)].
*[http://www.nature.com/modpathol/journal/v17/n3/fig_tab/3800050f13.html Pseudohyperplastic prostatic adenocarcinoma (nature.com)].
Notes:
*Usually associated with conventional (acinar) prostate adenocarcinoma.
*Pale abundant cytoplasm - similar to normal prostate.


==See also==
==See also==

Latest revision as of 03:40, 9 February 2016

Pseudohyperplastic prostatic adenocarcinoma
Diagnosis in short

Pseudohyperplastic carcinoma. H&E stain.

LM medium to large glands with an atypical morphology (papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation), nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement)
Subtypes subtype of prostate carcinoma
LM DDx benign prostatic tissue, foamy gland carcinoma
Grossing notes prostate biopsy, prostate chips, radical prostatectomy
Staging prostate cancer staging
Site prostate gland - see prostate carcinoma

Prevalence uncommon
Blood work +/-PSA elevated
Treatment see prostate carcinoma

Pseudohyperplastic prostatic adenocarcinoma, also pseudohyperplastic adenocarcinoma is an uncommon type of prostate carcinoma that may mimic benign prostate.

General

  • Uncommon <3% of cases in one series.[1]
  • May mimic benign prostate.[1]
  • Can be found with or without conventional prostatic adenocarcinoma (acinar type).

Microscopic

Features:[2][1]

  • Medium to large glands with an atypical morphology - key low power feature:
    • Papillary or pseudopapillary infoldings, luminal undulations, branching or cystic dilatation.
  • Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).

Notes:

  • Often associated with conventional (acinar) prostate adenocarcinoma.
  • Pale abundant cytoplasm - similar to normal prostate.

DDx:

  • Foamy gland carcinoma - often lack prominent nucleoli, smaller glands.
  • Benign prostatic glands - esp. at low power.

Images

www:

See also

References

  1. 1.0 1.1 1.2 Arista-Nasr J, Martinez-Benitez B, Valdes S, Hernández M, Bornstein-Quevedo L (2003). "Pseudohyperplastic prostatic adenocarcinoma in transurethral resections of the prostate". Pathol. Oncol. Res. 9 (4): 232–5. doi:PAOR.2003.9.4.0232. PMID 14688829.
  2. Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 77. ISBN 978-0443066771.