Difference between revisions of "Ovarian metastasis"
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| Caption = Ovary with a metastasis from breast carcinoma. [[H&E stain]]. | | Caption = Ovary with a metastasis from breast carcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = predominantly surface involvement and nodular (especially at low power), +/-signet ring cells (suggestive of GI or breast primary), [[lymphovascular invasion]] | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = ovarian primary tumours - esp. [[ovarian mucinous carcinoma]], [[serous carcinoma of the ovary]], [[endometrioid carcinoma of the ovary]] | | LMDDx = ovarian primary tumours - esp. [[ovarian mucinous carcinoma]], [[serous carcinoma of the ovary]], [[endometrioid carcinoma of the ovary]] | ||
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| Other = | | Other = | ||
| ClinDDx = ovarian primary | | ClinDDx = ovarian primary | ||
| Tx = | | Tx = dependent on primary - often chemotherapy and radiation, occasionally de-bulking (surgery) | ||
}} | }} | ||
An '''ovarian metastasis''' (also '''ovary with metastatic disease''' and '''metastatic ovarian disease''') is [[cancer]] in the [[ovary]] that arose elsewhere and spread to the ovary. | An '''ovarian metastasis''' (also '''ovary with metastatic disease''' and '''metastatic ovarian disease''') is [[cancer]] in the [[ovary]] that arose elsewhere and spread to the ovary. | ||
Revision as of 05:35, 28 January 2016
| Ovarian metastasis | |
|---|---|
| Diagnosis in short | |
 Ovary with a metastasis from breast carcinoma. H&E stain. | |
|
| |
| LM | predominantly surface involvement and nodular (especially at low power), +/-signet ring cells (suggestive of GI or breast primary), lymphovascular invasion |
| LM DDx | ovarian primary tumours - esp. ovarian mucinous carcinoma, serous carcinoma of the ovary, endometrioid carcinoma of the ovary |
| IHC | dependent on primary site |
| Gross | classically bilateral masses <10 cm |
| Site | ovary - see ovarian tumours |
|
| |
| Clinical history | +/-malignancy elsewhere |
| Signs | +/-abdominal mass |
| Symptoms | +/-pain, +/-abdominal distension |
| Blood work | serology suggestive of other primary, e.g. elevated CEA |
| Radiology | adnexal mass/ovarian mass |
| Prognosis | poor |
| Clin. DDx | ovarian primary |
| Treatment | dependent on primary - often chemotherapy and radiation, occasionally de-bulking (surgery) |
An ovarian metastasis (also ovary with metastatic disease and metastatic ovarian disease) is cancer in the ovary that arose elsewhere and spread to the ovary.
Generally
- Mostly Muellerian origin (uterus, fallopian tube) or pelvic peritoneum.
Common extramuellerian metastatic tumours:
- Breast.
- Gastrointestinal (GI) tract.
- Pseudomyxoma peritonei, usu. appendiceal origin.
- Krukenberg tumour = signet ring cell cancer with mucin production of GI origin.
Gross
Features favouring metastatic mucinous carcinoma (from the GI tract) over primary ovarian mucinous carcinoma:[1]
- Bilaterality - both ovaries involved.
- Small unilateral tumour size.
- <10 cm suggests metastasis.
- >13 cm = ovarian primary.
Microscopic
Features:
- Predominantly surface involvement and nodular at low power.
- +/-Signet ring cells (suggestive of GI or breast primary).
- Lymphovascular invasion.
Image
Ovarian metastasis - low mag. (WC/Nephron)
IHC
Ovarian tumours:
- Dipeptidase 1 (DPEP1) +ve.[2]
- CK7 +ve.
See also
References
- ↑ Yemelyanova, AV.; Vang, R.; Judson, K.; Wu, LS.; Ronnett, BM. (Jan 2008). "Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification.". Am J Surg Pathol 32 (1): 128-38. doi:10.1097/PAS.0b013e3180690d2d. PMID 18162780.
- ↑ Okamoto, T.; Matsumura, N.; Mandai, M.; Oura, T.; Yamanishi, Y.; Horiuchi, A.; Hamanishi, J.; Baba, T. et al. (Feb 2011). "Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1.". Mod Pathol 24 (2): 267-76. doi:10.1038/modpathol.2010.204. PMID 21076463.