Difference between revisions of "Small cell carcinoma of the prostate gland"

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'''Small cell carcinoma of the prostate gland''' is a rare type of [[prostate cancer]] with an aggressive course.
'''Small cell carcinoma of the prostate gland''' is a rare type of [[prostate cancer]] with an aggressive course.
''Neuroendocrine carcinoma of the prostate'' redirects to here.<ref name=pmid19092321>{{Cite journal  | last1 = Stein | first1 = ME. | last2 = Bernstein | first2 = Z. | last3 = Abacioglu | first3 = U. | last4 = Sengoz | first4 = M. | last5 = Miller | first5 = RC. | last6 = Meirovitz | first6 = A. | last7 = Zouhair | first7 = A. | last8 = Freixa | first8 = SV. | last9 = Poortmans | first9 = PH. | title = Small cell (neuroendocrine) carcinoma of the prostate: etiology, diagnosis, prognosis, and therapeutic implications--a retrospective study of 30 patients from the rare cancer network. | journal = Am J Med Sci | volume = 336 | issue = 6 | pages = 478-88 | month = Dec | year = 2008 | doi = 10.1097/MAJ.0b013e3181731e58 | PMID = 19092321 }}</ref><ref>{{Cite journal  | last1 = Alanee | first1 = S. | last2 = Moore | first2 = A. | last3 = Nutt | first3 = M. | last4 = Holland | first4 = B. | last5 = Dynda | first5 = D. | last6 = El-Zawahry | first6 = A. | last7 = McVary | first7 = KT. | title = Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer. | journal = Anticancer Res | volume = 35 | issue = 7 | pages = 4145-50 | month = Jul | year = 2015 | doi =  | PMID = 26124369 }}</ref>


==General==
==General==

Revision as of 04:54, 24 January 2016

Small cell carcinoma of the prostate gland
Diagnosis in short

Small cell carcinoma of the prostate. H&E stain.
LM small cells with nuclear moulding, stippled chromatin and high NC ratio, +/-high-grade acinar adenocarcinoma (common)
LM DDx small cell carcinoma of the urinary bladder, metastatic small cell carcinoma, poorly differentiated prostate carcinoma
IHC chromogranin A +ve, PSA -ve/+ve
Grossing notes prostate biopsy, prostate chips, radical prostatectomy
Site prostate gland - see prostate cancer
Prevalence rare
Prognosis poor
Clin. DDx other types of prostate cancer, metastatic cancer
Treatment chemotherapy

Small cell carcinoma of the prostate gland is a rare type of prostate cancer with an aggressive course.

Neuroendocrine carcinoma of the prostate redirects to here.[1][2]

General

Microscopic

Features:

  • Small cells with:
    • Nuclear moulding.
    • Stippled chromatin.
    • High NC ratio.
  • +/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.[3]

Notes:

DDx:

Images

Case

  • PCNEC - very low mag. (WC)

  • PCNEC - low mag. (WC)

  • PCNEC - intermed. mag. (WC)

  • PCNEC - high mag. (WC)

  • PCNEC - low mag. (WC)

  • PCNEC - intermed. mag. (WC)

  • PCNEC - high mag. (WC)

www

IHC

Features:[3]

  • PSA weak +ve/-ve.
  • Chromogranin +ve.

See also

References

  1. ↑ Stein, ME.; Bernstein, Z.; Abacioglu, U.; Sengoz, M.; Miller, RC.; Meirovitz, A.; Zouhair, A.; Freixa, SV. et al. (Dec 2008). "Small cell (neuroendocrine) carcinoma of the prostate: etiology, diagnosis, prognosis, and therapeutic implications--a retrospective study of 30 patients from the rare cancer network.". Am J Med Sci 336 (6): 478-88. doi:10.1097/MAJ.0b013e3181731e58. PMID 19092321.
  2. ↑ Alanee, S.; Moore, A.; Nutt, M.; Holland, B.; Dynda, D.; El-Zawahry, A.; McVary, KT. (Jul 2015). "Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer.". Anticancer Res 35 (7): 4145-50. PMID 26124369.
  3. ↑ 3.0 3.1 3.2 3.3 Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
  4. ↑ Epstein, JI.; Allsbrook, WC.; Amin, MB.; Egevad, LL. (Sep 2005). "The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.". Am J Surg Pathol 29 (9): 1228-42. PMID 16096414.
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