Difference between revisions of "Small cell carcinoma of the prostate gland"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = Prostate carcinoma with NEC -- high mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = Small cell carcinoma of the prostate. [[H&E stain]].
| Synonyms  =
| Synonyms  =
| Micro      = small cells with nuclear moulding, stippled chromatin and high [[NC ratio]], +/-high-grade acinar adenocarcinoma (common)
| Micro      = small cells with nuclear moulding, stippled chromatin and high [[NC ratio]], +/-high-grade acinar adenocarcinoma (common)
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===Images===
===Images===
====Case====
<gallery>
Image: Prostate carcinoma with NEC -- very low mag.jpg | PCNEC - very low mag. (WC)
Image: Prostate carcinoma with NEC -- low mag.jpg | PCNEC - low mag. (WC)
Image: Prostate carcinoma with NEC -- intermed mag.jpg | PCNEC - intermed. mag. (WC)
Image: Prostate carcinoma with NEC -- high mag.jpg | PCNEC - high mag. (WC)
Image: Prostate carcinoma with NEC - conv only -- low mag.jpg | PCNEC - low mag. (WC)
Image: Prostate carcinoma with NEC - conv only -- intermed mag.jpg | PCNEC - intermed. mag. (WC)
Image: Prostate carcinoma with NEC - conv only -- high mag.jpg | PCNEC - high mag. (WC)
</gallery>
====www====
====www====
*[http://www.webpathology.com/image.asp?case=23&n=25 SmCC of the prostate - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=23&n=25 SmCC of the prostate - low mag. (webpathology.com)].

Revision as of 04:45, 24 January 2016

Small cell carcinoma of the prostate gland
Diagnosis in short

Small cell carcinoma of the prostate. H&E stain.
LM small cells with nuclear moulding, stippled chromatin and high NC ratio, +/-high-grade acinar adenocarcinoma (common)
LM DDx small cell carcinoma of the urinary bladder, metastatic small cell carcinoma, poorly differentiated prostate carcinoma
IHC chromogranin A +ve, PSA -ve/+ve
Grossing notes prostate biopsy, prostate chips, radical prostatectomy
Site prostate gland - see prostate cancer
Prevalence rare
Prognosis poor
Clin. DDx other types of prostate cancer, metastatic cancer
Treatment chemotherapy

Small cell carcinoma of the prostate gland is a rare type of prostate cancer with an aggressive course.

General

Microscopic

Features:

  • Small cells with:
    • Nuclear moulding.
    • Stippled chromatin.
    • High NC ratio.
  • +/-High-grade acinar adenocarcinoma, i.e. conventional prostate carcinoma, seen in ~50% of cases.[1]

Notes:

DDx:

Images

Case

  • PCNEC - very low mag. (WC)

  • PCNEC - low mag. (WC)

  • PCNEC - intermed. mag. (WC)

  • PCNEC - high mag. (WC)

  • PCNEC - low mag. (WC)

  • PCNEC - intermed. mag. (WC)

  • PCNEC - high mag. (WC)

www

IHC

Features:[1]

  • PSA weak +ve/-ve.
  • Chromogranin +ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Furtado, P.; Lima, MV.; Nogueira, C.; Franco, M.; Tavora, F. (2011). "Review of small cell carcinomas of the prostate.". Prostate Cancer 2011: 543272. doi:10.1155/2011/543272. PMID 22110988.
  2. ↑ Epstein, JI.; Allsbrook, WC.; Amin, MB.; Egevad, LL. (Sep 2005). "The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma.". Am J Surg Pathol 29 (9): 1228-42. PMID 16096414.
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