Difference between revisions of "Inflammatory pseudopolyp"

Inflammatory pseudopolyp
	External resources
EHVSC	9992

Inflammatory pseudopolyp
	Diagnosis in short
	; Inflammatory polyp. H&E stain.
LM	polypoid shape, inflammatory cells - esp. neutrophils
LM DDx	juvenile polyp, mucosal prolapse, adenomatous polyps
Site	colon, rectum, others
Clinical history	+/-inflammatory bowel disease
Prevalence	not common
Prognosis	benign
Clin. DDx	other types of polyps

Latest revision as of 16:14, 20 January 2016

Inflammatory pseudopolyp is a benign polypoid lesion usually seen in the context of inflammatory bowel disease.

It is also referred to as inflammatory polyp.

General

Not a true polyp.
The label inflammatory pseudopolyp = inflammatory bowel disease (IBD).
- If there is no history of IBD... reconsider the diagnosis.

Microscopic

Features:

Polypoid shape.
Inflammation - esp. neutrophils - key feature.

Negatives:

No nuclear atypia.
- May have focal nuclear hyperchromasia and nuclear enlargement.
No dilated glands.

DDx:

Images

IP - very low mag.
IP - low mag.
IP - intermed. mag.
IP - high mag.

www:

Sign out

SIGMOID COLON POLYP, PERI-DIVERTICULAR, BIOPSY:
- INFLAMMATORY PSEUDOPOLYP.

POLYP, DESCENDING COLON, BIOPSY:
- INFLAMED POLYPOID FRAGMENT OF COLORECTAL-TYPE MUCOSA.
-- NEGATIVE FOR DYSPLASIA.

Diverticular disease-associated

Polyp, Sigmoid Colon, Polypectomy:
- Colonic mucosa with ulceration, acute inflammation and granulation tissue.
- NEGATIVE for dysplasia.

Comment:
This may represent a polyp seen in the context of diverticular disease. Other 
considerations include ischemia, idiopathic inflammation and infections. 
Clinical correlation is suggested.

Block letters

 POLYP (AT EDGE OF DIVERTICULUM), SIGMOID COLON, POLYPECTOMY:
- GRANULATION TISSUE AND SCANT BENIGN EPITHELIUM.
- NO EVIDENCE OF DYSPLASIA.

Micro

The sections show a fragment of colorectal mucosa with focal ulceration, acute inflammation and a well-vascularized stroma with plump stromal cells. Occasional stromal cells have nuclear hyperchromasia.

Alternate

The sections show a fragment of tissue with scant benign epithelium, acute and chronic inflammation (neutrophils and plasma cells predominantly), abundant blood vessels with reactive endothelial cells and plump stromal cells. Occasional stromal cells have nuclear hyperchromasia but do not show significant atypia.

References

↑ Aust, DE.; Rüschoff, J. (Jul 2011). "[Polyps of the colorectum: non-neoplastic and non-hamartomatous].". Pathologe 32 (4): 297-302. doi:10.1007/s00292-011-1435-1. PMID 21607734.

[pmid21607734-1] Aust, DE.; Rüschoff, J. (Jul 2011). "[Polyps of the colorectum: non-neoplastic and non-hamartomatous].". Pathologe 32 (4): 297-302. doi:10.1007/s00292-011-1435-1. PMID 21607734.

[1]

@@ Line 1: / Line 1: @@
-#redirect [[Gastrointestinal_tract_polyps#Inflammatory pseudopolyp]]
+{{ Infobox diagnosis
+| Name       = {{PAGENAME}}
+| Image      = Inflammatory polyp -- low mag.jpg
+| Width      =
+| Caption    = Inflammatory polyp. [[H&E stain]].
+| Micro      = polypoid shape, inflammatory cells - esp. [[neutrophils]]
+| Subtypes   =
+| LMDDx      = [[juvenile polyp]], [[mucosal prolapse]], [[adenomatous polyps]]
+| Stains     =
+| IHC        =
+| EM         =
+| Molecular  =
+| IF         =
+| Gross      =
+| Grossing   =
+| Site       = [[colon]], [[rectum]], others
+| Assdx      =
+| Syndromes  =
+| Clinicalhx = +/-[[inflammatory bowel disease]]
+| Signs      =
+| Symptoms   =
+| Prevalence = not common
+| Bloodwork  =
+| Rads       =
+| Endoscopy  =
+| Prognosis  = benign
+| Other      =
+| ClinDDx    = other types of polyps
+}}
+{{ Infobox external links
+| Name           = {{PAGENAME}}
+| EHVSC          = 9992
+| pathprotocols  =
+| wikipedia      =
+| pathoutlines   =
+}}
+'''Inflammatory pseudopolyp''' is a benign polypoid lesion usually seen in the context of [[inflammatory bowel disease]].
+It is also referred to as '''inflammatory polyp'''.
+==General==
+*Not a true polyp.
+*The label ''inflammatory pseudopolyp'' = [[inflammatory bowel disease]] (IBD).
+**If there is no history of IBD... reconsider the diagnosis.
+==Microscopic==
+Features:
+*Polypoid shape.
+*Inflammation - esp. neutrophils - '''key feature'''.
+Negatives:
+*No nuclear atypia.
+**May have focal nuclear hyperchromasia and nuclear enlargement.
+*No dilated glands.
+DDx:
+*[[Juvenile polyp]].
+*[[Mucosal prolapse]].<ref name=pmid21607734>{{Cite journal  | last1 = Aust | first1 = DE. | last2 = Rüschoff | first2 = J. | title = [Polyps of the colorectum: non-neoplastic and non-hamartomatous]. | journal = Pathologe | volume = 32 | issue = 4 | pages = 297-302 | month = Jul | year = 2011 | doi = 10.1007/s00292-011-1435-1 | PMID = 21607734 }}</ref>
+**[[Solitary rectal ulcer]].
+===Images===
+<gallery>
+Image: Inflammatory polyp -- very low mag.jpg | IP - very low mag.
+Image: Inflammatory polyp -- low mag.jpg | IP - low mag.
+Image: Inflammatory polyp -- intermed mag.jpg | IP - intermed. mag.
+Image: Inflammatory polyp -- high mag.jpg | IP - high mag.
+</gallery>
+www:
+*[http://www.humpath.com/spip.php?article8234&id_document=18554 Pseudopolyp (humpath.com)].
+*[http://missinglink.ucsf.edu/lm/IDS_106_LowerGI/Lower_GI_histo_small/24-UC-pseudoplp.jpg Pseudopolyp (ucsf.edu)].
+==Sign out==
+<pre>
+SIGMOID COLON POLYP, PERI-DIVERTICULAR, BIOPSY:
+- INFLAMMATORY PSEUDOPOLYP.
+</pre>
+<pre>
+POLYP, DESCENDING COLON, BIOPSY:
+- INFLAMED POLYPOID FRAGMENT OF COLORECTAL-TYPE MUCOSA.
+-- NEGATIVE FOR DYSPLASIA.
+</pre>
+===Diverticular disease-associated===
+<pre>
+Polyp, Sigmoid Colon, Polypectomy:
+- Colonic mucosa with ulceration, acute inflammation and granulation tissue.
+- NEGATIVE for dysplasia.
+Comment:
+This may represent a polyp seen in the context of diverticular disease. Other
+considerations include ischemia, idiopathic inflammation and infections.
+Clinical correlation is suggested.
+</pre>
+====Block letters====
+<pre>
+ POLYP (AT EDGE OF DIVERTICULUM), SIGMOID COLON, POLYPECTOMY:
+- GRANULATION TISSUE AND SCANT BENIGN EPITHELIUM.
+- NO EVIDENCE OF DYSPLASIA.
+</pre>
+===Micro===
+The sections show a fragment of colorectal mucosa with focal ulceration, acute inflammation and a well-vascularized stroma with plump stromal cells.  Occasional stromal cells have nuclear hyperchromasia.
+====Alternate====
+The sections show a fragment of tissue with scant benign epithelium, acute and chronic
+inflammation (neutrophils and plasma cells predominantly), abundant blood vessels with
+reactive endothelial cells and plump stromal cells. Occasional stromal cells have nuclear hyperchromasia but do not show significant atypia.
+==See also==
+*[[Gastrointestinal tract polyps]].
+*[[Mucosal prolapse syndrome]].
+*[[Colon]].
+*[[Nasal polyps]].
+==References==
+{{Reflist|1}}
+[[Category:Diagnosis]]