Difference between revisions of "C-cell hyperplasia"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = C-cell hyperplasia in MEN 2 -- intermed mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = C-cell hyperplasia. [[H&E stain]].
| Synonyms  =
| Synonyms  =
| Micro      =
| Micro      =
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| LMDDx      = [[medullary thyroid carcinoma]]
| LMDDx      = [[medullary thyroid carcinoma]]
| Stains    =
| Stains    =
| IHC        =
| IHC        = CEA +ve, chromogranin A +ve, synaptophysin +ve
| EM        =
| EM        =
| Molecular  =
| Molecular  =
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===Images===
===Images===
<gallery>
Image: C-cell hyperplasia in MEN 2 -- very low mag.jpg | CCH in MEN - very low mag. (WC)
Image: C-cell hyperplasia in MEN 2 -- low mag.jpg | CCH in MEN - low mag. (WC)
Image: C-cell hyperplasia in MEN 2 - alt -- low mag.jpg | CCH in MEN - low mag. (WC)
Image: C-cell hyperplasia in MEN 2 -- intermed mag.jpg | CCH in MEN - intermed. mag. (WC)
Image: C-cell hyperplasia in MEN 2 -- high mag.jpg | CCH in MEN - high mag. (WC)
Image: C-cell hyperplasia in MEN 2 - alt -- high mag.jpg | CCH in MEN - high mag. (WC)
Image: C-cell hyperplasia in MEN 2 -- very high mag.jpg | CCH in MEN - very high mag. (WC)
Image: C-cell hyperplasia in MEN 2 - alt -- very high mag.jpg | CCH in MEN - very high mag. (WC)
</gallery>
<gallery>
Image: C-cell hyperplasia in MEN 2 - chromo A -- intermed mag.jpg | CCH in MEN - chromo A - intermed. mag. (WC)
Image: C-cell hyperplasia in MEN 2 - chromo A -- high mag.jpg | CCH in MEN - chromo A - high mag. (WC)
Image: C-cell hyperplasia in MEN 2 - chromo A -- very high mag.jpg | CCH in MEN - chromo A - very high mag. (WC)
Image: C-cell hyperplasia in MEN 2 - CEA -- low mag.jpg | CCH in MEN - CEA - low mag. (WC)
Image: C-cell hyperplasia in MEN 2 - CEA -- intermed mag.jpg | CCH in MEN - CEA - intermed. mag. (WC)
Image: C-cell hyperplasia in MEN 2 - CEA -- high mag.jpg | CCH in MEN - CEA - high mag. (WC)
Image: C-cell hyperplasia in MEN 2 - CEA -- very high mag.jpg | CCH in MEN - CEA - very high mag. (WC)
</gallery>
====www====
*[http://www.nature.com/modpathol/journal/v16/n8/fig_tab/3880836f2.html CCH - crappy B&W image (nature.com)].<ref>{{Cite journal  | last1 = Guyétant | first1 = S. | last2 = Josselin | first2 = N. | last3 = Savagner | first3 = F. | last4 = Rohmer | first4 = V. | last5 = Michalak | first5 = S. | last6 = Saint-André | first6 = JP. | title = C-cell hyperplasia and medullary thyroid carcinoma: clinicopathological and genetic correlations in 66 consecutive patients. | journal = Mod Pathol | volume = 16 | issue = 8 | pages = 756-63 | month = Aug | year = 2003 | doi = 10.1097/01.MP.0000081727.75778.0C | PMID = 12920219 }}</ref>
*[http://www.nature.com/modpathol/journal/v16/n8/fig_tab/3880836f2.html CCH - crappy B&W image (nature.com)].<ref>{{Cite journal  | last1 = Guyétant | first1 = S. | last2 = Josselin | first2 = N. | last3 = Savagner | first3 = F. | last4 = Rohmer | first4 = V. | last5 = Michalak | first5 = S. | last6 = Saint-André | first6 = JP. | title = C-cell hyperplasia and medullary thyroid carcinoma: clinicopathological and genetic correlations in 66 consecutive patients. | journal = Mod Pathol | volume = 16 | issue = 8 | pages = 756-63 | month = Aug | year = 2003 | doi = 10.1097/01.MP.0000081727.75778.0C | PMID = 12920219 }}</ref>
*[http://www.nature.com/modpathol/journal/v16/n8/fig_tab/3880836f3.htm CCH - crappy B&W image (nature.com)].
*[http://www.nature.com/modpathol/journal/v16/n8/fig_tab/3880836f3.htm CCH - crappy B&W image (nature.com)].
Line 63: Line 85:
*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=4849 CCH (unibas.ch)].
*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=4849 CCH (unibas.ch)].
*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=10739 Nodular CCH (unibas.ch)].
*[http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=10739 Nodular CCH (unibas.ch)].
==IHC==
*Chromogranin A +ve.
*CEA +ve.
*Synaptophysin +ve.


==See also==
==See also==

Revision as of 06:41, 31 December 2015

C-cell hyperplasia
Diagnosis in short

C-cell hyperplasia. H&E stain.
LM DDx medullary thyroid carcinoma
IHC CEA +ve, chromogranin A +ve, synaptophysin +ve
Gross not apparent
Site thyroid gland
Syndromes Multiple endocrine neoplasia type 2A
Prevalence uncommon
Blood work calcitonin level elevated
Prognosis benign in itself
Treatment prophylatic surgery

C-cell hyperplasia is a pathology of the thyroid gland and considered the precursor for medullary thyroid carcinoma.

General

Gross

  • Not visible.

Microscopic

Features:

  • Location:[4]
    • Mid portion of lobe to upper third of lobe.
      • Not at the poles.
      • Not in the isthmus.
  • Definitions vary.[5]
    • One definition - either of the following:[1]
      1. >50 C-cells per low-power field (x100).
        • This part of the definition suffers from LPFitis.
      2. "Medullary thyroid carcinoma confined to the thyroid gland and no larger than 10 mm in greatest dimension."
    • Another definition:
      • Invasion of the basement membrane with stromal reaction.
    • A third definition:
      • "Several clusters" of more than six C cells.

Images

  • CCH in MEN - very low mag. (WC)

  • CCH in MEN - low mag. (WC)

  • CCH in MEN - low mag. (WC)

  • CCH in MEN - intermed. mag. (WC)

  • CCH in MEN - high mag. (WC)

  • CCH in MEN - high mag. (WC)

  • CCH in MEN - very high mag. (WC)

  • CCH in MEN - very high mag. (WC)

  • CCH in MEN - chromo A - intermed. mag. (WC)

  • CCH in MEN - chromo A - high mag. (WC)

  • CCH in MEN - chromo A - very high mag. (WC)

  • CCH in MEN - CEA - low mag. (WC)

  • CCH in MEN - CEA - intermed. mag. (WC)

  • CCH in MEN - CEA - high mag. (WC)

  • CCH in MEN - CEA - very high mag. (WC)

www

IHC

  • Chromogranin A +ve.
  • CEA +ve.
  • Synaptophysin +ve.

See also

References

  1. ↑ 1.0 1.1 Machens A, Hoffmann F, Sekulla C, Dralle H (December 2009). "Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer". Endocr. Relat. Cancer 16 (4): 1291–8. doi:10.1677/ERC-09-0136. PMID 19726541. http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291.
  2. ↑ Tyer, NM.; Braunstein, GD.; Frishberg, D.. "Unusual case of multiple endocrine neoplasia type 2A syndrome without medullary thyroid carcinoma.". Endocr Pract 17 (2): e4-7. doi:10.4158/EP10157.CR. PMID 21134882.
  3. ↑ Etit, D.; Faquin, WC.; Gaz, R.; Randolph, G.; DeLellis, RA.; Pilch, BZ. (Nov 2008). "Histopathologic and clinical features of medullary microcarcinoma and C-cell hyperplasia in prophylactic thyroidectomies for medullary carcinoma: a study of 42 cases.". Arch Pathol Lab Med 132 (11): 1767-73. doi:10.1043/1543-2165-132.11.1767. PMID 18976013.
  4. ↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf. Accessed on: 7 April 2012.
  5. ↑ Raphael S. 17 January 2011.
  6. ↑ Guyétant, S.; Josselin, N.; Savagner, F.; Rohmer, V.; Michalak, S.; Saint-André, JP. (Aug 2003). "C-cell hyperplasia and medullary thyroid carcinoma: clinicopathological and genetic correlations in 66 consecutive patients.". Mod Pathol 16 (8): 756-63. doi:10.1097/01.MP.0000081727.75778.0C. PMID 12920219.
  7. ↑ URL: http://www.forpath.org/workshops/0201/html/case_7.asp. Accessed on: 21 May 2013.
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