Difference between revisions of "Nucleolus"

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[[Image:Epithelioid_sarcoma_-_cropped_-_very_high_mag.jpg|thumb|right|[[Micrograph]] showing a tumour (epithelioid sarcoma) with prominent nucleoli. [[H&E stain]].]]
The '''nucleolus''' (plural '''nucleoli''') is a thingy in the nucleus that may give the pathologist a clue to what they are looking at.
The '''nucleolus''' (plural '''nucleoli''') is a thingy in the nucleus that may give the pathologist a clue to what they are looking at.


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Example:
Example:
*Reed-Sternberg cell ([[Hodgkin lymphoma]]) ~ 5-7 micrometers.<ref name=Ref_PCPBoD8_329>{{Ref PCPBoD8|329}}</ref>
*Reed-Sternberg cell ([[Hodgkin lymphoma]]) ~ 5-7 micrometers.<ref name=Ref_PCPBoD8_329>{{Ref PCPBoD8|329}}</ref>
===Image===
<gallery>
Image:Glioblastoma_with_extreme_nuclear_enlargement_-_very_high_mag.jpg | Extreme nuclear enlargement with huge macronucleoli. (WC)
</gallery>


==Red nucleolus==
==Red nucleolus==
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*[[Melanoma]].
*[[Melanoma]].
*[[Serous carcinoma]].
*[[Serous carcinoma]].
*[[Hereditary leiomyomatosis and renal cell carcinoma|Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma‎‎]].


==Large nucleolus==
==Large nucleolus==
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*[[Prostatic adenocarcinoma]].
*[[Prostatic adenocarcinoma]].
*[[Oncocytoma]].
*[[Oncocytoma]].
*Mammary carcinoma, no special type.
*[[Invasive ductal carcinoma of the breast|Mammary carcinoma, no special type]].
*[[Embryonal carcinoma]].
*[[Embryonal carcinoma]].
*[[Squamous metaplasia of the uterine cervix]].


==Small==
==Small==
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Examples:
Examples:
*[[Small cell carcinoma]].
*[[Small cell carcinoma]].
*Neuroendocrine carcinoma.
*[[Neuroendocrine carcinoma]].


==See also==
==See also==

Latest revision as of 05:47, 21 October 2015

Micrograph showing a tumour (epithelioid sarcoma) with prominent nucleoli. H&E stain.

The nucleolus (plural nucleoli) is a thingy in the nucleus that may give the pathologist a clue to what they are looking at.

Generally speaking, large nucleoli suggest something is happening - they are associated with gene transcription. Large nucleoli are seen in malignancies and reactive conditions.

Macronucleolus

Almost the size of RBC ~ 6-7 micrometers.

Example:

Image

Red nucleolus

Large - can be seen with 10x objective.

Examples:

Large nucleolus

Large - can be seen with 10x objective.

Examples:

Medium-sized nucleolus

Medium - can be seen well with 20x objective.

Examples:

Small

Small - hard to see at 20x objective, seen with 40x objective.

Examples:

Indistinct nucleolus

Not present - cannot see with 40x objective.

Examples:

See also

References

  1. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 329. ISBN 978-1416054542.