Difference between revisions of "CD99"
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'''CD99''' is a commonly available [[immunostain]] with various uses. | '''CD99''' is a commonly available [[immunostain]] with various uses. It stains a lot of different tumour and has been described by one soft tissue pathologist as ''slutty''. | ||
==Positive== | ==Positive== | ||
===Membrane staining=== | |||
*[[Ewing sarcoma]] - diffuse (plasma membrane) staining. | |||
*Lymphoblastic lymphoma/leukemia. | |||
*[[Angiomatoid fibrous histiocytoma]]. | |||
*[[Desmoplastic small round cell tumour]]. | |||
===Weak/cytoplasmic staining=== | |||
*[[Synovial sarcoma]]. | |||
*[[Rhabdomyosarcoma]]. | |||
*[[Rhabdoid tumour]]. | |||
===Others=== | |||
*[[Malignant melanoma]] (9 of 10 cases<ref name=pmid11789717>{{Cite journal | last1 = Monteagudo | first1 = C. | last2 = Calduch | first2 = L. | last3 = Navarro | first3 = S. | last4 = Joan-Figueroa | first4 = A. | last5 = Llombart-Bosch | first5 = A. | title = CD99 immunoreactivity in atypical fibroxanthoma: a common feature of diagnostic value. | journal = Am J Clin Pathol | volume = 117 | issue = 1 | pages = 126-31 | month = Jan | year = 2002 | doi = 10.1309/2EXB-70CW-3U6P-VQ6H | PMID = 11789717 }}</ref>). | *[[Malignant melanoma]] (9 of 10 cases<ref name=pmid11789717>{{Cite journal | last1 = Monteagudo | first1 = C. | last2 = Calduch | first2 = L. | last3 = Navarro | first3 = S. | last4 = Joan-Figueroa | first4 = A. | last5 = Llombart-Bosch | first5 = A. | title = CD99 immunoreactivity in atypical fibroxanthoma: a common feature of diagnostic value. | journal = Am J Clin Pathol | volume = 117 | issue = 1 | pages = 126-31 | month = Jan | year = 2002 | doi = 10.1309/2EXB-70CW-3U6P-VQ6H | PMID = 11789717 }}</ref>). | ||
*[[Atypical fibroxanthoma]] (19 of 26 cases<ref name=pmid11789717/>). | *[[Atypical fibroxanthoma]] (19 of 26 cases<ref name=pmid11789717/>). | ||
==Negative== | |||
*[[Squamous cell carcinoma]].<ref name=pmid11789717/> | |||
*[[Undifferentiated small round cell sarcoma with t(4;19)]] (CIC-DUX sarcoma) - negative or weak positive. | |||
==See also== | ==See also== | ||
Latest revision as of 12:40, 15 October 2015
CD99 is a commonly available immunostain with various uses. It stains a lot of different tumour and has been described by one soft tissue pathologist as slutty.
Positive
Membrane staining
- Ewing sarcoma - diffuse (plasma membrane) staining.
- Lymphoblastic lymphoma/leukemia.
- Angiomatoid fibrous histiocytoma.
- Desmoplastic small round cell tumour.
Weak/cytoplasmic staining
Others
- Malignant melanoma (9 of 10 cases[1]).
- Atypical fibroxanthoma (19 of 26 cases[1]).
Negative
- Squamous cell carcinoma.[1]
- Undifferentiated small round cell sarcoma with t(4;19) (CIC-DUX sarcoma) - negative or weak positive.