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| {{hidden|Diagnosis|<center>[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]]</center><br> | | {{hidden|Diagnosis|<center>[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]]</center><br> |
| Comment:<br> | | Comment:<br> |
| The hyalinized papillae and prominent nucleoli with halos are characteristic. These tumour often have a mixture of morphologic patterns as seen here (tubulocystic, papillary), and tend to have an aggressive behaviour. The definitive stain is FH (fumarate hydratase); it is lost in HLRCC. The IHC pattern doesn't fit [[papillary RCC]]; HLRCC is typically CK7 negative, CK20 negative and CD10 negative. | | The hyalinized papillae and prominent nucleoli with halos are characteristic. These tumours often have a mixture of morphologic patterns as seen here (tubulocystic, papillary), and tend to have an aggressive behaviour. The definitive stain is FH (fumarate hydratase); it is lost in HLRCC. The IHC pattern doesn't fit [[papillary RCC]]; HLRCC is typically CK7 negative, CK20 negative and CD10 negative. |
| }} | | }} |
| <br> | | <br> |
| | |
| ===Other cases=== | | ===Other cases=== |
| {{Cases navigation}} | | {{Cases navigation}} |
Latest revision as of 16:36, 1 October 2015
Provided clinical history
43 year old woman, renal mass
Site
Left kidney
Primary image
Low magnification. H&E stain.
Differential diagnosis
Additional tests
More history
Expand More history
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hysterectomy for fibroids when 33 years old, skin rash. Brother diagnosised with PaRCC when 41 years old - died 1 year later. Uncle died of RCC is 40s.
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Ask a colleague
Expand Ask a colleague
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Smells syndromic. I'd bet the "skin rash" is leiomyomas.
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Stains
ExpandAlcian blue/PAS to Bilirubin |
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Alcian blue/PAS | Expand Dr Torres would ask why! |
Alican blue pH 1.0 | Expand Dr Torres would ask why! |
Alcian blue pH 2.5 | Expand Dr Torres would ask why! |
Auramine | Expand Dr Torres would ask why! |
Bielchowsky | Expand Dr Torres would ask why! |
Bilirubin | Expand Dr Torres would ask why! |
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ExpandColloidal iron to Fontana-Masson |
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Colloidal iron | Expand Dr Torres would ask why! |
Congo red | Expand Dr Torres would ask why! |
Cresyl violet | Expand Dr Torres would ask why! |
Dieterle | Expand Dr Torres would ask why! |
Diff Quik | Expand Dr Torres would ask why! |
Fontana-Masson | Expand Dr Torres would ask why! |
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ExpandGallyas to Gremelius |
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Gallyas | Expand Dr Torres would ask why! |
Giemsa | Expand Dr Torres would ask why! |
GMS | Expand Dr Torres would ask why! |
Gomori's trichrome | Expand Dr Torres would ask why! |
Gram | Expand Dr Torres would ask why! |
Gremelius | Expand Dr Torres would ask why! |
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ExpandJMS to Mucicarmine |
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JMS | Expand Dr Torres would ask why! |
Jones | Expand Dr Torres would ask why! |
Kinyoun | Expand Dr Torres would ask why! |
Luxol fast blue | Expand Dr Torres would ask why! |
Masson trichrome | Expand Dr Torres would ask why! |
M-MAS | Expand Dr Torres would ask why! |
Movat | Expand Dr Torres would ask why! |
Mucicarmine | Expand Dr Torres would ask why! |
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ExpandOil red O to Prussian blue |
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Oil red O | Expand Dr Torres would ask why! |
Orecein | Expand Dr Torres would ask why! |
PAS | Expand Dr Torres would ask why! |
PASD | Expand Dr Torres would ask why! |
PASF | Expand Dr Torres would ask why! |
PTAH | Expand Dr Torres would ask why! |
Prussian blue | Expand Dr Torres would ask why! |
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ExpandReticulin to Ziehl-Neelsen |
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Reticulin | Expand Dr Torres would ask why! |
Sudan black B | Expand Dr Torres would ask why! |
Toluidine blue | Expand Dr Torres would ask why! |
Verhoeff | Expand Dr Torres would ask why! |
Von Kossa | Expand Dr Torres would ask why! |
Warthin-Starry | Expand Dr Torres would ask why! |
Ziehl-Neeslen | Expand Dr Torres would ask why! |
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IHC
ExpandAlpha-1 AT to Cathepsin K |
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alpha-1 AT | Expand Dr Torres would ask why! |
ACTH | Expand Dr Torres would ask why! |
AE1/AE1 | Expand Dr Torres would ask why! |
alpha-fetoprotein | Expand Dr Torres would ask why! |
Alk-I | Expand Dr Torres would ask why! |
AMACR | Expand Dr Torres would ask why! |
AR | Expand Dr Torres would ask why! |
ATRX | Expand Dr Torres would ask why! |
Beta2-microglobulin | Expand Dr Torres would ask why! |
B72.3 | Expand Dr Torres would ask why! |
Beta-catenin | Expand Dr Torres would ask why! |
BCL2 | Expand Dr Torres would ask why! |
BCL6 | Expand Dr Torres would ask why! |
BCLxL | Expand Dr Torres would ask why! |
C3 comp | Expand Dr Torres would ask why! |
CA9 | Expand Dr Torres would ask why! |
Calcitonin | Expand Dr Torres would ask why! |
Calponin | Expand Dr Torres would ask why! |
Calretinin | Expand Dr Torres would ask why! |
CAM5.2 | Expand Dr Torres would ask why! |
Cathepsin K | Expand Dr Torres would ask why! |
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ExpandCD10 to Chromogranin |
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CD10 | Expand NEGATIVE |
CD117 | Expand Dr Torres would ask why! |
CD138 | Expand Dr Torres would ask why! |
CD15 | Expand Dr Torres would ask why! |
CD1a | Expand Dr Torres would ask why! |
CD20 | Expand Dr Torres would ask why! |
CD21 | Expand Dr Torres would ask why! |
CD23 | Expand Dr Torres would ask why! |
CD3 | Expand Dr Torres would ask why! |
CD30 | Expand Dr Torres would ask why! |
CD31 | Expand Dr Torres would ask why! |
CD34 | Expand Dr Torres would ask why! |
CD35 | Expand Dr Torres would ask why! |
CD4 | Expand Dr Torres would ask why! |
CD43 | Expand Dr Torres would ask why! |
CD45 (LCA) | Expand Dr Torres would ask why! |
CD5 | Expand Dr Torres would ask why! |
CD56 | Expand Dr Torres would ask why! |
CD57 | Expand Dr Torres would ask why! |
CD68 | Expand Dr Torres would ask why! |
CD7 | Expand Dr Torres would ask why! |
CD79a | Expand Dr Torres would ask why! |
CD8 | Expand Dr Torres would ask why! |
CD99 | Expand Dr Torres would ask why! |
CDX2 | Expand Dr Torres would ask why! |
CEA-m | Expand Dr Torres would ask why! |
Chromogranin | Expand Dr Torres would ask why! |
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ExpandHBME-1 to IgM |
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HBME-1 | Expand Dr Torres would ask why! |
HBV core | Expand Dr Torres would ask why! |
HBV surface | Expand Dr Torres would ask why! |
H-caldesmon | Expand Dr Torres would ask why! |
HCG | Expand Dr Torres would ask why! |
Helicobacter | Expand Dr Torres would ask why! |
Hepatocyte | Expand Dr Torres would ask why! |
HER2/neu | Expand Dr Torres would ask why! |
HHV-8 | Expand Dr Torres would ask why! |
HMB-45 | Expand Dr Torres would ask why! |
HNF1beta | Expand Dr Torres would ask why! |
HPV | Expand Dr Torres would ask why! |
HSV-I | Expand Dr Torres would ask why! |
HSV-II | Expand Dr Torres would ask why! |
IDH-1 | Expand Dr Torres would ask why! |
Inhibin | Expand Dr Torres would ask why! |
INI1 (BAF47) | Expand Dr Torres would ask why! |
Insulin | Expand Dr Torres would ask why! |
Kappa | Expand Dr Torres would ask why! |
Ki-67 | Expand Dr Torres would ask why! |
Lambda | Expand Dr Torres would ask why! |
Leu 7 | Expand Dr Torres would ask why! |
IgA | Expand Dr Torres would ask why! |
IgG | Expand Dr Torres would ask why! |
IgM | Expand Dr Torres would ask why! |
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ExpandLH to PDGFR |
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LH | Expand Dr Torres would ask why! |
LIN28 | Expand Dr Torres would ask why! |
Lysozyme | Expand Dr Torres would ask why! |
mammoglobin | Expand Dr Torres would ask why! |
MAP2 | Expand Dr Torres would ask why! |
MCV | Expand Dr Torres would ask why! |
Melanin A | Expand Dr Torres would ask why! |
MHC class I | Expand Dr Torres would ask why! |
MITF | Expand Dr Torres would ask why! |
MUM1 | Expand Dr Torres would ask why! |
Myeloperoxidase | Expand Dr Torres would ask why! |
MYO D1 | Expand Dr Torres would ask why! |
Myoglobin | Expand Dr Torres would ask why! |
Napsin | Expand Dr Torres would ask why! |
NF | Expand Dr Torres would ask why! |
NKX3.1 | Expand Dr Torres would ask why! |
NSE | Expand Dr Torres would ask why! |
OCT3/4 | Expand Dr Torres would ask why! |
p16 | Expand Dr Torres would ask why! |
P501S | Expand Dr Torres would ask why! |
p53 | Expand Dr Torres would ask why! |
p57 | Expand Dr Torres would ask why! |
p63 | Expand Dr Torres would ask why! |
Pankeratin | Expand Dr Torres would ask why! |
PAX2 | Expand Dr Torres would ask why! |
PAX5 | Expand Dr Torres would ask why! |
PAX8 | Expand POSITIVE |
PCNA | Expand Dr Torres would ask why! |
PDGFR | Expand Dr Torres would ask why! |
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ExpandPLAP to WT1 |
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PLAP | Expand Dr Torres would ask why! |
PNL-2C | Expand Dr Torres would ask why! |
Prolactin | Expand Dr Torres would ask why! |
PSA | Expand Dr Torres would ask why! |
PSAP | Expand Dr Torres would ask why! |
RCC | Expand Dr Torres would ask why! |
S-100 | Expand Dr Torres would ask why! |
SALL4 | Expand Dr Torres would ask why! |
Smooth muscle actin | Expand Dr Torres would ask why! |
Somatostatin | Expand Dr Torres would ask why! |
STAT6 | Expand Dr Torres would ask why! |
Synaptophysin | Expand Dr Torres would ask why! |
TdT | Expand Dr Torres would ask why! |
TFE3 | Expand NEGATIVE |
TFEB | Expand Dr Torres would ask why! |
Thyroglobulin | Expand Dr Torres would ask why! |
Toxoplasma | Expand Dr Torres would ask why! |
TSH | Expand Dr Torres would ask why! |
TTF-1 | Expand Dr Torres would ask why! |
Ubiquitin | Expand Dr Torres would ask why! |
UCHL1 (PGP9.5) | Expand Dr Torres would ask why! |
Ulex Europaeus | Expand Dr Torres would ask why! |
Vimentin | Expand Dr Torres would ask why! |
VIP | Expand Dr Torres would ask why! |
VZV | Expand Dr Torres would ask why! |
WT-1 | Expand Dr Torres would ask why! |
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Molecular testing
Chromosomal translocations
ExpandTranslocations Chr 1-10 |
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t(1;13) PAX7-FKHR | Expand Dr Torres would ask why! |
t(2,13) PAX3-FKHR | Expand Dr Torres would ask why! |
t(8;14) MYC-IGH | Expand Dr Torres would ask why! |
t(9;22) BCR-ABL | Expand Dr Torres would ask why! |
t(9;22) CHN-EWS | Expand Dr Torres would ask why! |
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ExpandTranslocations Chr 11-13 |
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t(11;14) CCND1-IGH | Expand Dr Torres would ask why! |
t(11;22) EWS-WT1 | Expand Dr Torres would ask why! |
t(11;22) FLI1-EWS | Expand Dr Torres would ask why! |
t(12;15) ETV6-NTRK3 | Expand Dr Torres would ask why! |
t(12;16) FUS-ATF1 | Expand Dr Torres would ask why! |
t(12;16) CHOP-TLS | Expand Dr Torres would ask why! |
t(12;22) EWS-ATF1 | Expand Dr Torres would ask why! |
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ExpandTranslocations Chr 14-22 |
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t(14,18) IGH-BCL2 | Expand Dr Torres would ask why! |
t(15;17) PML-RARA | Expand Dr Torres would ask why! |
t(16;21) FUS-ERG | Expand Dr Torres would ask why! |
t(17;22) COLA1-PDGFB | Expand Dr Torres would ask why! |
t(21;22) EWS-ERG | Expand Dr Torres would ask why! |
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ExpandTranslocations Chr X & Y |
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t(X;1) PRCC-TFE3 | Expand Dr Torres would ask why! |
t(X;17) TFE3-ASPL | Expand Dr Torres would ask why! |
t(X;18) SYT-SSX | Expand Dr Torres would ask why! |
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Other molecular tests
ExpandMolecular tests (A-B) |
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ALK sequencing | Expand Dr Torres would ask why! |
B cell clonality Southern / PCR | Expand Dr Torres would ask why! |
BCL2 PCR | Expand Dr Torres would ask why! |
BRAF sequencing | Expand Dr Torres would ask why! |
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ExpandMolecular tests (C-H) |
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EBV PCR | Expand Dr Torres would ask why! |
EGRF sequencing | Expand Dr Torres would ask why! |
H3F3A sequencing | Expand Dr Torres would ask why! |
HHV-8 PCR | Expand Dr Torres would ask why! |
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ExpandMolecular tests (K-Z) |
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KIT sequencing | Expand Dr Torres would ask why! |
LOH 1p/19q PCR | Expand Dr Torres would ask why! |
T cell clonality Southern / PCR | Expand Dr Torres would ask why! |
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Diagnosis
Other cases
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| Number | |
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| Subspecialty (Difficulty) |
Autopsy pathology (jr,sr, f/e)
Breast pathology (jr,sr, f/e)
Cardiovascular pathology (jr,sr, f/e)
Cytopathology (jr,sr, f/e)
Dermatopathology (jr,sr, f/e)
Endocrine pathology (jr,sr, f/e)
Forensic pathology (jr,sr, f/e)
Gastrointestinal pathology (jr,sr, f/e)
Genitourinary pathology (jr,sr, f/e)
Gynecologic pathology (jr,sr, f/e)
Hematopathology (jr,sr, f/e)
Head and neck pathology (jr,sr, f/e)
Lymph node pathology (jr,sr, f/e)
Medical kidney pathology (jr,sr, f/e)
Molecular pathology (jr,sr, f/e)
Neuropathology (jr,sr, f/e)
Pediatric pathology (jr,sr, f/e)
Pulmonary pathology (jr,sr, f/e)
Placental pathology (jr,sr, f/e)
Soft tissue pathology (jr,sr, f/e) |
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| Difficulty | |
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