Difference between revisions of "Pulmonary meningothelial-like nodule"
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'''Pulmonary meningothelial-like nodule''', abbreviated '''MLN''', is a common benign finding in the [[lung]]. | '''Pulmonary meningothelial-like nodule''', abbreviated '''MLN''', is a common benign finding in the [[lung]]. | ||
They are also referred to as '''minute pulmonary meningothelial-like nodules''' (abbreviated '''MPMN''') | They are also referred to as '''minute pulmonary meningothelial-like nodules''' (abbreviated '''MPMN''') and '''minute pulmonary chemodectoma'''.<ref name=pmid2830799>{{Cite journal | last1 = Gaffey | first1 = MJ. | last2 = Mills | first2 = SE. | last3 = Askin | first3 = FB. | title = Minute pulmonary meningothelial-like nodules. A clinicopathologic study of so-called minute pulmonary chemodectoma. | journal = Am J Surg Pathol | volume = 12 | issue = 3 | pages = 167-75 | month = Mar | year = 1988 | doi = | PMID = 2830799 }}</ref> | ||
==General== | ==General== | ||
*Benign.<ref name=pmid24023559>{{Cite journal | last1 = Lee | first1 = SK. | last2 = Kim | first2 = GJ. | last3 = Kim | first3 = YJ. | last4 = Leem | first4 = AY. | last5 = Hwang | first5 = ED. | last6 = Kim | first6 = SK. | last7 = Chang | first7 = J. | last8 = Kang | first8 = YA. | last9 = Kim | first9 = SY. | title = Minute pulmonary meningothelial-like nodules simulating hematogenous lung metastasis: a case report. | journal = Tuberc Respir Dis (Seoul) | volume = 75 | issue = 2 | pages = 67-70 | month = Aug | year = 2013 | doi = 10.4046/trd.2013.75.2.67 | PMID = 24023559 }}</ref> | *Benign.<ref name=pmid24023559>{{Cite journal | last1 = Lee | first1 = SK. | last2 = Kim | first2 = GJ. | last3 = Kim | first3 = YJ. | last4 = Leem | first4 = AY. | last5 = Hwang | first5 = ED. | last6 = Kim | first6 = SK. | last7 = Chang | first7 = J. | last8 = Kang | first8 = YA. | last9 = Kim | first9 = SY. | title = Minute pulmonary meningothelial-like nodules simulating hematogenous lung metastasis: a case report. | journal = Tuberc Respir Dis (Seoul) | volume = 75 | issue = 2 | pages = 67-70 | month = Aug | year = 2013 | doi = 10.4046/trd.2013.75.2.67 | PMID = 24023559 }}</ref> | ||
*Very common - seen in almost half of well sampled lobectomies.<ref name=pmid19047895/> | *Very common - seen in almost half of well sampled lobectomies.<ref name=pmid19047895/> | ||
* | *May be grouped with ''pulmonary meningioma'' in the larger category ''primary pleuropulmonary meningothelial proliferations''.<ref name=pmid26291511>{{Cite journal | last1 = Weissferdt | first1 = A. | last2 = Tang | first2 = X. | last3 = Suster | first3 = S. | last4 = Wistuba | first4 = II. | last5 = Moran | first5 = CA. | title = Pleuropulmonary Meningothelial Proliferations: Evidence for a Common Histogenesis. | journal = Am J Surg Pathol | volume = | issue = | pages = | month = Aug | year = 2015 | doi = 10.1097/PAS.0000000000000489 | PMID = 26291511 }}</ref> | ||
* | *Can mimic [[metastasis|metastatic deposits]].<ref name=pmid23109985>{{Cite journal | last1 = Kfoury | first1 = H. | last2 = Arafah | first2 = MA. | last3 = Arafah | first3 = MM. | last4 = Alnassar | first4 = S. | last5 = Hajjar | first5 = W. | title = Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature. | journal = Korean J Pathol | volume = 46 | issue = 1 | pages = 87-91 | month = Feb | year = 2012 | doi = 10.4132/KoreanJPathol.2012.46.1.87 | PMID = 23109985 }}</ref><ref name=pmid24023559/> | ||
Associations: | Associations: | ||
| Line 14: | Line 15: | ||
==Gross== | ==Gross== | ||
* | *Tan or yellow nodules - pleural or parenchymal - typically 1-3 mm.<ref name=pmid2830799/> | ||
Note: | Note: | ||
*Found in all lobes.<ref name=pmid19144385>{{Cite journal | last1 = Mizutani | first1 = E. | last2 = Tsuta | first2 = K. | last3 = Maeshima | first3 = AM. | last4 = Asamura | first4 = H. | last5 = Matsuno | first5 = Y. | title = Minute pulmonary meningothelial-like nodules: clinicopathologic analysis of 121 patients. | journal = Hum Pathol | volume = 40 | issue = 5 | pages = 678-82 | month = May | year = 2009 | doi = 10.1016/j.humpath.2008.08.018 | PMID = 19144385 }}</ref> | *Found in all lobes.<ref name=pmid19144385>{{Cite journal | last1 = Mizutani | first1 = E. | last2 = Tsuta | first2 = K. | last3 = Maeshima | first3 = AM. | last4 = Asamura | first4 = H. | last5 = Matsuno | first5 = Y. | title = Minute pulmonary meningothelial-like nodules: clinicopathologic analysis of 121 patients. | journal = Hum Pathol | volume = 40 | issue = 5 | pages = 678-82 | month = May | year = 2009 | doi = 10.1016/j.humpath.2008.08.018 | PMID = 19144385 }}</ref> | ||
*May be seen on imaging if large.<ref name=pmid24023559/> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid2830799/> | ||
*Cell nests - expanding alveolar septa. | |||
DDx: | DDx: | ||
| Line 35: | Line 37: | ||
*CD56 +ve (18 of 18 cases<ref name=pmid19047895>{{Cite journal | last1 = Mukhopadhyay | first1 = S. | last2 = El-Zammar | first2 = OA. | last3 = Katzenstein | first3 = AL. | title = Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 487-95 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e31818b1de7 | PMID = 19047895 }}</ref>). | *CD56 +ve (18 of 18 cases<ref name=pmid19047895>{{Cite journal | last1 = Mukhopadhyay | first1 = S. | last2 = El-Zammar | first2 = OA. | last3 = Katzenstein | first3 = AL. | title = Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 487-95 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e31818b1de7 | PMID = 19047895 }}</ref>). | ||
*EMA +ve (11 of 11 cases<ref name=pmid19047895/>). | *EMA +ve (11 of 11 cases<ref name=pmid19047895/>). | ||
*Vimentin +ve ( | *Vimentin +ve (10 of 14 cases<ref name=pmid2830799/>). | ||
==See also== | ==See also== | ||
Revision as of 15:16, 28 September 2015
Pulmonary meningothelial-like nodule, abbreviated MLN, is a common benign finding in the lung.
They are also referred to as minute pulmonary meningothelial-like nodules (abbreviated MPMN) and minute pulmonary chemodectoma.[1]
General
- Benign.[2]
- Very common - seen in almost half of well sampled lobectomies.[3]
- May be grouped with pulmonary meningioma in the larger category primary pleuropulmonary meningothelial proliferations.[4]
- Can mimic metastatic deposits.[5][2]
Associations:
- More common in females (odds ratio 2).[6]
- Seen more frequently in the context of cancer - esp. adenocarcinoma.[6]
Gross
- Tan or yellow nodules - pleural or parenchymal - typically 1-3 mm.[1]
Note:
Microscopic
Features:[1]
- Cell nests - expanding alveolar septa.
DDx:
- Lung tumourlet.
- Poorly differentiated carcinoma.
- Lobular carcinoma.[5]
Images
IHC
Features:
See also
References
- ↑ 1.0 1.1 1.2 1.3 Gaffey, MJ.; Mills, SE.; Askin, FB. (Mar 1988). "Minute pulmonary meningothelial-like nodules. A clinicopathologic study of so-called minute pulmonary chemodectoma.". Am J Surg Pathol 12 (3): 167-75. PMID 2830799.
- ↑ 2.0 2.1 2.2 Lee, SK.; Kim, GJ.; Kim, YJ.; Leem, AY.; Hwang, ED.; Kim, SK.; Chang, J.; Kang, YA. et al. (Aug 2013). "Minute pulmonary meningothelial-like nodules simulating hematogenous lung metastasis: a case report.". Tuberc Respir Dis (Seoul) 75 (2): 67-70. doi:10.4046/trd.2013.75.2.67. PMID 24023559.
- ↑ 3.0 3.1 3.2 Mukhopadhyay, S.; El-Zammar, OA.; Katzenstein, AL. (Apr 2009). "Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity.". Am J Surg Pathol 33 (4): 487-95. doi:10.1097/PAS.0b013e31818b1de7. PMID 19047895.
- ↑ Weissferdt, A.; Tang, X.; Suster, S.; Wistuba, II.; Moran, CA. (Aug 2015). "Pleuropulmonary Meningothelial Proliferations: Evidence for a Common Histogenesis.". Am J Surg Pathol. doi:10.1097/PAS.0000000000000489. PMID 26291511.
- ↑ 5.0 5.1 5.2 Kfoury, H.; Arafah, MA.; Arafah, MM.; Alnassar, S.; Hajjar, W. (Feb 2012). "Mimicry of Minute Pulmonary Meningothelial-like Nodules to Metastatic Deposits in a Patient with Infiltrating Lobular Carcinoma: A Case Report and Review of the Literature.". Korean J Pathol 46 (1): 87-91. doi:10.4132/KoreanJPathol.2012.46.1.87. PMID 23109985.
- ↑ 6.0 6.1 6.2 Mizutani, E.; Tsuta, K.; Maeshima, AM.; Asamura, H.; Matsuno, Y. (May 2009). "Minute pulmonary meningothelial-like nodules: clinicopathologic analysis of 121 patients.". Hum Pathol 40 (5): 678-82. doi:10.1016/j.humpath.2008.08.018. PMID 19144385.