Difference between revisions of "Adamantinoma"
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| Micro = biphasic tumour - epithelial component & fibro-osseous component | | Micro = biphasic tumour - epithelial component & fibro-osseous component | ||
| Subtypes = classic, differentiated | | Subtypes = classic, differentiated | ||
| LMDDx = | | LMDDx = [[vascular tumours]] ([[epithelioid hemangioendothelioma]]), [[metastatic carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 28: | Line 28: | ||
| ClinDDx = [[osteosarcoma]] | | ClinDDx = [[osteosarcoma]] | ||
}} | }} | ||
'''Adamantinoma''' is an uncommon benign [[bone tumour]]. It should '''not''' be confused with ''[[adenomatoid tumour]]''. | '''Adamantinoma''' is an uncommon benign [[bone tumour]]. | ||
It should '''not''' be confused with ''[[adenomatoid tumour]]''. | |||
==General== | ==General== | ||
| Line 72: | Line 74: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F1/ Adamantinoma (nih.gov)].<ref name=pmid18279517>{{Cite journal | last1 = Jain | first1 = D. | last2 = Jain | first2 = VK. | last3 = Vasishta | first3 = RK. | last4 = Ranjan | first4 = P. | last5 = Kumar | first5 = Y. | title = Adamantinoma: a clinicopathological review and update. | journal = Diagn Pathol | volume = 3 | issue = | pages = 8 | month = | year = 2008 | doi = 10.1186/1746-1596-3-8 | PMID = 18279517 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F1/ Adamantinoma (nih.gov)].<ref name=pmid18279517>{{Cite journal | last1 = Jain | first1 = D. | last2 = Jain | first2 = VK. | last3 = Vasishta | first3 = RK. | last4 = Ranjan | first4 = P. | last5 = Kumar | first5 = Y. | title = Adamantinoma: a clinicopathological review and update. | journal = Diagn Pathol | volume = 3 | issue = | pages = 8 | month = | year = 2008 | doi = 10.1186/1746-1596-3-8 | PMID = 18279517 }}</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F2/ Adamantinoma (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276480/figure/F2/ Adamantinoma (nih.gov)]. | ||
*[http://www.tumorlibrary.com/case/images/1878.jpg Adamantinoma (tumorlibrary.com)]. | |||
*[http://www.tumorlibrary.com/case/images/1890.jpg Adamantinoma (tumorlibrary.com)]. | |||
*[http://www.tumorlibrary.com/case/images/1891.jpg Adamantinoma (tumorlibrary.com)]. | |||
*Epithelium can be focal - Diagnostico Med Br [http://www.diagnostico.med.br/osteopat/54d.JPG] | |||
==IHC== | ==IHC== | ||
Features:<ref name=pathcon_adam/> | Features:<ref name=pathcon_adam/> | ||
*CK14 +ve (HMWK).<ref>URL: [http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]. Accessed on: 28 April 2011.</ref> | *CK14 +ve (HMWK).<ref>URL: [http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm]. Accessed on: 28 April 2011.</ref> | ||
*CK19 +ve (LMWK). | *[[CK19]] +ve (LMWK). | ||
*CK8/18 -ve (LMWK). | *CK8/18 -ve (LMWK). | ||
| Line 84: | Line 90: | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
==External links== | |||
*[http://www.tumorlibrary.com/case/list.jsp?category=Bone+Tumors&category_type=Adamantinoma&order=diagnosis+ASC Adamantinoma case (tumorlibrary.com)]. | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Chondro-osseous tumours]] | [[Category:Chondro-osseous tumours]] | ||
Latest revision as of 21:30, 20 August 2015
| Adamantinoma | |
|---|---|
| Diagnosis in short | |
 Adamantinoma. H&E stain. | |
|
| |
| LM | biphasic tumour - epithelial component & fibro-osseous component |
| Subtypes | classic, differentiated |
| LM DDx | vascular tumours (epithelioid hemangioendothelioma), metastatic carcinoma |
| Site | bone - classically tibia, other sites |
|
| |
| Prevalence | uncommon |
| Prognosis | benign +/-locally aggressive |
| Clin. DDx | osteosarcoma |
Adamantinoma is an uncommon benign bone tumour.
It should not be confused with adenomatoid tumour.
General
Features:[1]
- Rare: < 1% of bone tumours.
- Typically 25-35 years old.
- Benign, may be locally aggressive.
Gross
- Classically mid portion of tibia.[2]
- Fibula common.
- Reported in many other sites.
Radiology
- Intracortical, radiolucent.
Microscopic
Features:
- Biphasic tumour:[2]
- Fibro-osseous component.
- Spindle cells.
- Epithelial component.
- Classically nests of basaloid cells.
- Fibro-osseous component.
Note:
- It is described as resembling ameloblastoma,[2] but the resemblance isn't striking.
DDx:[3]
- Vascular tumours (epithelioid hemangioendothelioma).
- Metastatic carcinoma.
Subtypes
Subdivided into:[2]
- Classic.
- Differentiated - less than 20 years old only.
Images
Adamantinoma - intermed. mag. (WC)
www:
- Adamantinoma (southbaypath.org).[4]
- Adamantinoma (nih.gov).[2]
- Adamantinoma (nih.gov).
- Adamantinoma (tumorlibrary.com).
- Adamantinoma (tumorlibrary.com).
- Adamantinoma (tumorlibrary.com).
- Epithelium can be focal - Diagnostico Med Br [1]
![[1]](http://www.diagnostico.med.br/osteopat/54d.JPG){kind=link}
IHC
Features:[3]
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 650. ISBN 978-0781765275.
- ↑ 2.0 2.1 2.2 2.3 2.4 Jain, D.; Jain, VK.; Vasishta, RK.; Ranjan, P.; Kumar, Y. (2008). "Adamantinoma: a clinicopathological review and update.". Diagn Pathol 3: 8. doi:10.1186/1746-1596-3-8. PMID 18279517.
- ↑ 3.0 3.1 URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2. Accessed on: 28 April 2011.
- ↑ URL: http://southbaypath.org/CaseImages/sb5260/sb5260.htm. Accessed on: 7 December 2010.
- ↑ URL: http://www.nordiqc.org/Epitopes/Cytokeratins/cytokeratins.htm. Accessed on: 28 April 2011.