Difference between revisions of "Case 51"
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Low magnification. H&E stain.
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===Provided clinical history=== | ===Provided clinical history=== | ||
26 year old man, left thyroid swelling, increasing in | 26 year old man, left thyroid swelling, increasing in size for 7 months. | ||
===Site=== | ===Site=== | ||
Left Thyroid | Left Thyroid Gland. | ||
===Primary image=== | ===Primary image=== | ||
[[Image: Hyalinized trabecular tumour - low mag.jpg |500px|link=|center|]] | [[Image:Hyalinized trabecular tumour - low mag.jpg |500px|link=|center|]] | ||
<center>Low magnification. [[H&E stain]].</center> | <center>Low magnification. [[H&E stain]].</center> | ||
| Line 21: | Line 20: | ||
===Additional tests=== | ===Additional tests=== | ||
====More history==== | ====More history==== | ||
{{hidden|More history|<center> | {{hidden|More history|<center> | ||
The swelling was nodular, measured 2 cm x 2 cm and was firm, nontender. Serum T3, T4 and TSH were within normal limits. Ultrasound showed a large hypoechoic lesion of 2.1 cm x 2.1 cm in the left lobe of the thyroid with calcification.</center>}} | |||
====Ask a colleague==== | ====Ask a colleague==== | ||
{{hidden|Ask a colleague|<center> | {{hidden|Ask a colleague|<center>This is a variant of [[papillary thyroid carcinoma]]</center>}} | ||
====Stains==== | ====Stains==== | ||
| Line 76: | Line 76: | ||
| alk1= | | alk1= | ||
| amacr= | | amacr= | ||
| ar= | | ar= | ||
| b2microglobulin= | | b2microglobulin= | ||
| b72_3= | | b72_3= | ||
| Line 115: | Line 115: | ||
| chromo= | | chromo= | ||
| ck17= | | ck17= | ||
| ck19= | | ck19= -ve | ||
| ck20= | | ck20= | ||
| ck34be12= | | ck34be12= | ||
| ck5_6= | | ck5_6= | ||
| ck7= | | ck7= | ||
| cmv= | | cmv= | ||
| cmyc= | | cmyc= | ||
| Line 126: | Line 126: | ||
| dog1= | | dog1= | ||
| ebv= | | ebv= | ||
| ema= | | ema= | ||
| erpr= | | erpr= | ||
| f_viii= | | f_viii= | ||
| f_xiiia= | | f_xiiia= | ||
| Line 133: | Line 133: | ||
| fsh= | | fsh= | ||
| gastrin= | | gastrin= | ||
| gcdfp= | | gcdfp= | ||
| gfap= | | gfap= | ||
| gh= | | gh= | ||
| glucagon= | | glucagon= | ||
| hbme1= | | hbme1= -ve | ||
| hbv_core= | | hbv_core= | ||
| hbv_surf= | | hbv_surf= | ||
| Line 155: | Line 155: | ||
| insulin= | | insulin= | ||
| kappa= | | kappa= | ||
| ki67= | | ki67= +ve, strong cell membrane and cytoplasmic positivity | ||
| lambda= | | lambda= | ||
| leu7= | | leu7= | ||
| Line 171: | Line 171: | ||
| myog= | | myog= | ||
| nf= | | nf= | ||
| nse= | | nse= +ve | ||
| oct3_4= | | oct3_4= | ||
| p16= | | p16= | ||
| p53= | | p53= | ||
| p63= | | p63= -ve | ||
| panker= | | panker= | ||
| pax2= | | pax2= | ||
| Line 185: | Line 185: | ||
| pnl-2c= | | pnl-2c= | ||
| prolactin= | | prolactin= | ||
| psa= | | psa= | ||
| psap= | | psap= | ||
| s100= | | s100= | ||
| sma= | | sma= | ||
| Line 193: | Line 193: | ||
| tdt= | | tdt= | ||
| tfe3= | | tfe3= | ||
| thyrogl= | | thyrogl= +ve | ||
| toxopl= | | toxopl= | ||
| tsh= | | tsh= | ||
| Line 229: | Line 229: | ||
| tx_18= | | tx_18= | ||
}} | }} | ||
===Diagnosis=== | ===Diagnosis=== | ||
{{hidden|Diagnosis|<center>[[ | {{hidden|Diagnosis|<center>[[Hyalinizing trabecular tumour]]</center>}} | ||
<br> | <br> | ||
===Other cases=== | ===Other cases=== | ||
{{Cases navigation}} | {{Cases navigation}} | ||
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[[Category:Cases]] | [[Category:Cases]] | ||
[[Category:Cases in | [[Category:Cases in endocrine pathology]] | ||
[[Category:Cases difficulty 4]] | [[Category:Cases difficulty 4]] | ||
[[Category:Cases in | [[Category:Cases in endocrine pathology - senior]] | ||
Latest revision as of 03:44, 10 July 2015
Provided clinical history
26 year old man, left thyroid swelling, increasing in size for 7 months.
Site
Left Thyroid Gland.
Primary image
Intermediate magnification
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High magnification
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Differential diagnosis
Differential diagnosis
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Additional tests
More history
More history
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Ask a colleague
Ask a colleague
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Stains
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IHC
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Chromosomal translocations
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Diagnosis
Diagnosis
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