Difference between revisions of "WT-1"
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[[File:Wilms_tumor_protein_wt1_immunohistocehmistry_glioblastoma.JPG|thumb|right|250px|WT-1 staining in [[glioblastoma]].]] | |||
'''Wilms Tumor Protein 1''', commonly known by the abbreviation '''WT-1''', is a commonly used [[immunostain]] in [[gynecologic pathology]] and [[neuropathology]]. | '''Wilms Tumor Protein 1''', commonly known by the abbreviation '''WT-1''', is a commonly used [[immunostain]] in [[gynecologic pathology]] and [[neuropathology]]. | ||
Revision as of 12:09, 16 June 2015
WT-1 staining in glioblastoma.
Wilms Tumor Protein 1, commonly known by the abbreviation WT-1, is a commonly used immunostain in gynecologic pathology and neuropathology.
Tumours with positive staining
- Astrocytoma/Glioblastoma (cytoplasmic) ~80-90% [1]
- Mesothelioma[2]
- Serous ovarian carcinoma[3]
See also
References
- ↑ Schittenhelm, J.; Beschorner, R.; Simon, P.; Tabatabai, G.; Herrmann, C.; Schlaszus, H.; Capper, D.; Weller, M. et al. (Feb 2009). "Diagnostic value of WT1 in neuroepithelial tumours.". Neuropathol Appl Neurobiol 35 (1): 69-81. doi:10.1111/j.1365-2990.2008.00957.x. PMID 18466223.
- ↑ Yaziji, H.; Battifora, H.; Barry, TS.; Hwang, HC.; Bacchi, CE.; McIntosh, MW.; Kussick, SJ.; Gown, AM. (Apr 2006). "Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity.". Mod Pathol 19 (4): 514-23. doi:10.1038/modpathol.3800534. PMID 16554731.
- ↑ Al-Hussaini, M.; Stockman, A.; Foster, H.; McCluggage, WG. (Feb 2004). "WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma.". Histopathology 44 (2): 109-15. PMID 14764054.