Difference between revisions of "Renal mucinous tubular and spindle cell carcinoma"
Jump to navigation
Jump to search
(+infobox) |
(→Stains) |
||
| Line 64: | Line 64: | ||
==Stains== | ==Stains== | ||
*[[Mucicarmine stain|Mucicarmine]] - mucin. | *[[Mucicarmine stain|Mucicarmine]] - mucin +ve. | ||
*[[Alcian blue stain|Alcian blue]] pH 2.5 - mucin. | *[[Alcian blue stain|Alcian blue]] pH 2.5 - mucin +ve. | ||
==IHC== | ==IHC== | ||
Revision as of 20:07, 11 May 2015
| Renal mucinous tubular and spindle cell carcinoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | mucin (foamy macrophages) - may be scant, spindle cells, small tubules - lined by cuboidal epithelium |
| IHC | CK7 +ve, AMACR +ve, CD10 -ve, AE1/AE3 +ve |
| Gross | solid, greyish-yellow or tan-yellow, well-circumscribed |
| Grossing notes | partial nephrectomy grossing, total nephrectomy for tumour grossing |
| Site | kidney - see kidney tumours |
|
| |
| Prevalence | rare |
| Prognosis | good |
| Treatment | surgical excision |
Renal mucinous tubular and spindle cell carcinoma, abbreviated RMTSCC, is a rare malignant epithelial neoplasm of the kidney.
It is also known as renal mucinous tubular spindle cell carcinoma and mucinous tubular and spindle cell carcinoma of the kidney.[1]
General
Gross
Features:[4]
- Solid.
- Greyish-yellow or tan-yellow.
- Well-circumscribed.
Microscopic
Features:[5]
- Mucin (foamy macrophages) - may be scant.
- Spindle cells - key feature.
- Small tubules - lined by cuboidal epithelium.[4]
DDx:
- Sarcomatoid papillary renal cell carcinoma[6] (papillary renal cell carcinoma with sarcomatoid differentiation).
- Papillary renal cell carcinoma.
Images
www:
- RMTSCC (ouhsc.edu).
- RMTSCC (cttr.org).[7]
- RMTSCC (diagnosticpathology.org).[4]
- RMTSCC (ijpmonline.org).[8]
Stains
- Mucicarmine - mucin +ve.
- Alcian blue pH 2.5 - mucin +ve.
IHC
Features:[9]
- CK7 +ve.
- AMACR +ve.
- CD10 -ve.
- AE1/AE3 +ve.
Note:
- Immunophenotype overlaps with papillary renal cell carcinoma.Cite error: Invalid
<ref>tag; invalid names, e.g. too many
See also
References
- ↑ Brandal, P.; Lie, AK.; Bassarova, A.; Svindland, A.; Risberg, B.; Danielsen, H.; Heim, S. (Feb 2006). "Genomic aberrations in mucinous tubular and spindle cell renal cell carcinomas.". Mod Pathol 19 (2): 186-94. doi:10.1038/modpathol.3800499. PMID 16258504.
- ↑ Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
- ↑ Geramizadeh B, Salehipour M, Moradi A (2009). "Mucinous tubular and spindle cell carcinoma of kidney: a rare case report and review of the literature". Indian J Pathol Microbiol 52 (4): 514–6. doi:10.4103/0377-4929.56144. PMID 19805959.
- ↑ 4.0 4.1 4.2 Wu, XR.; Chen, YH.; Sha, JJ.; Zhao, L.; Huang, JW.; Bo, JJ.; Liu, DM.; Huang, YR. (Dec 2013). "Renal mucinous tubular and spindle cell carcinoma: a report of 8 cases and review of the literature.". Diagn Pathol 8 (1): 206. doi:10.1186/1746-1596-8-206. PMID 24330589.
- ↑ Trabelsi A, Stita W, Yacoubi MT, Rammeh S, Hmissa S, Korbi S (December 2008). "Renal mucinous tubular and spindle cell carcinoma". Can Urol Assoc J 2 (6): 635–6. PMC 2593603. PMID 19066686. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593603/.
- ↑ Dhillon J, Amin MB, Selbs E, Turi GK, Paner GP, Reuter VE (January 2009). "Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change". Am. J. Surg. Pathol. 33 (1): 44–9. doi:10.1097/PAS.0b013e3181829ed5. PMID 18941398.
- ↑ URL: http://www.cttr.org/cms/?p=1406. Accessed on: 28 February 2014.
- ↑ Hussain, M.; Ud Din, N.; Azam, M.; Loya, A.. "Mucinous tubular and spindle cell carcinoma of kidney: a clinicopathologic study of six cases.". Indian J Pathol Microbiol 55 (4): 439-42. doi:10.4103/0377-4929.107776. PMID 23455776.
- ↑ Ferlicot S, Allory Y, Compérat E, et al. (December 2005). "Mucinous tubular and spindle cell carcinoma: a report of 15 cases and a review of the literature". Virchows Arch. 447 (6): 978–83. doi:10.1007/s00428-005-0036-x. PMID 16231179.