Difference between revisions of "Thecoma"
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'''Thecoma''' is an [[ovarian tumour]] in the [[Sex cord-stromal tumours|sex-cord stromal group of tumours]]. | |||
==General== | |||
*Associated with compression & atrophy of ovarian cortex, thought to arise from medulla.<ref name=pmid18164409>{{Cite journal | last1 = Nocito | first1 = AL. | last2 = Sarancone | first2 = S. | last3 = Bacchi | first3 = C. | last4 = Tellez | first4 = T. | title = Ovarian thecoma: clinicopathological analysis of 50 cases. | journal = Ann Diagn Pathol | volume = 12 | issue = 1 | pages = 12-6 | month = Feb | year = 2008 | doi = 10.1016/j.anndiagpath.2007.01.011 | PMID = 18164409 }}</ref> | |||
*Approximately 50% have symptoms related to estrogen secretion.<ref name=pmid16810055/> | |||
**May also be viralizing. | |||
==Gross== | |||
Features: | |||
*Solid yellow mass, usu. well-circumscribed.<ref name=Ref_AoGP398>{{Ref AoGP|398}}</ref> | |||
DDx: | |||
*[[Ovarian fibroma]] - white solid mass.<ref name=Ref_AoGP398>{{Ref AoGP|398}}</ref> | |||
*Fibroma-thecoma (fibrothecoma). | |||
==Microscopic== | |||
Features:<ref name=pmid16810055/> | |||
*Nuclei with oval to spindle morphology. | |||
*Abundant cytoplasm that is pale, vaculolated -- '''key feature'''. | |||
===Images=== | |||
<gallery> | |||
Image:Thecoma_low_mag.jpg | Thecoma - low mag. (WC) | |||
Image:Thecoma_high_mag.jpg | Thecoma - high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
*Alpha-inhibin +ve (90%+).<ref name=pmid16810055/> | |||
==References== | |||
{{Reflist|2}} | |||
==See also== | |||
*[[Ovarian tumours]]. | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Ovarian tumours]] | |||
Revision as of 05:35, 2 May 2015
Thecoma is an ovarian tumour in the sex-cord stromal group of tumours.
General
- Associated with compression & atrophy of ovarian cortex, thought to arise from medulla.[1]
- Approximately 50% have symptoms related to estrogen secretion.[2]
- May also be viralizing.
Gross
Features:
- Solid yellow mass, usu. well-circumscribed.[3]
DDx:
- Ovarian fibroma - white solid mass.[3]
- Fibroma-thecoma (fibrothecoma).
Microscopic
Features:[2]
- Nuclei with oval to spindle morphology.
- Abundant cytoplasm that is pale, vaculolated -- key feature.
Images
Thecoma - low mag. (WC)
Thecoma - high mag. (WC)
IHC
- Alpha-inhibin +ve (90%+).[2]
References
- ↑ Nocito, AL.; Sarancone, S.; Bacchi, C.; Tellez, T. (Feb 2008). "Ovarian thecoma: clinicopathological analysis of 50 cases.". Ann Diagn Pathol 12 (1): 12-6. doi:10.1016/j.anndiagpath.2007.01.011. PMID 18164409.
- ↑ 2.0 2.1 2.2 Cite error: Invalid
<ref>tag; no text was provided for refs namedpmid16810055 - ↑ 3.0 3.1 Rose, Alan G. (2008). Atlas of Gross Pathology with Histologic Correlation (1st ed.). Cambridge University Press. pp. 398. ISBN 978-0521868792.