Difference between revisions of "Anal squamous cell carcinoma"
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'''Anal squamous cell carcinoma''' is | '''Anal squamous cell carcinoma''' is the most common type of [[anal cancer]].<ref name=pmid25741135>{{Cite journal | last1 = Ghosn | first1 = M. | last2 = Kourie | first2 = HR. | last3 = Abdayem | first3 = P. | last4 = Antoun | first4 = J. | last5 = Nasr | first5 = D. | title = Anal cancer treatment: Current status and future perspectives. | journal = World J Gastroenterol | volume = 21 | issue = 8 | pages = 2294-2302 | month = Feb | year = 2015 | doi = 10.3748/wjg.v21.i8.2294 | PMID = 25741135 }}</ref> | ||
It is also known as '''anal squamous carcinoma''' and '''squamous cell carcinoma of the anus'''. | It is also known as '''anal squamous carcinoma''' and '''squamous cell carcinoma of the anus'''. | ||
==General== | ==General== | ||
*Most common form of anal cancer. | *Most common form of anal cancer.<ref name=pmid25741135/> | ||
* | *Strong association with [[HPV]].<ref name=pmid23616200>{{Cite journal | last1 = Cornall | first1 = AM. | last2 = Roberts | first2 = JM. | last3 = Garland | first3 = SM. | last4 = Hillman | first4 = RJ. | last5 = Grulich | first5 = AE. | last6 = Tabrizi | first6 = SN. | title = Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11. | journal = Int J Cancer | volume = 133 | issue = 9 | pages = 2253-8 | month = Nov | year = 2013 | doi = 10.1002/ijc.28228 | PMID = 23616200 }}</ref> | ||
Risk factors:<ref name=pmid23806153>{{Cite journal | last1 = Kutlubay | first1 = Z. | last2 = Engin | first2 = B. | last3 = Zara | first3 = T. | last4 = Tüzün | first4 = Y. | title = Anogenital malignancies and premalignancies: Facts and controversies. | journal = Clin Dermatol | volume = 31 | issue = 4 | pages = 362-73 | month = | year = | doi = 10.1016/j.clindermatol.2013.01.003 | PMID = 23806153 }}</ref> | Risk factors:<ref name=pmid23806153>{{Cite journal | last1 = Kutlubay | first1 = Z. | last2 = Engin | first2 = B. | last3 = Zara | first3 = T. | last4 = Tüzün | first4 = Y. | title = Anogenital malignancies and premalignancies: Facts and controversies. | journal = Clin Dermatol | volume = 31 | issue = 4 | pages = 362-73 | month = | year = | doi = 10.1016/j.clindermatol.2013.01.003 | PMID = 23806153 }}</ref> | ||
Revision as of 18:02, 19 March 2015
Anal squamous cell carcinoma is the most common type of anal cancer.[1]
It is also known as anal squamous carcinoma and squamous cell carcinoma of the anus.
General
Risk factors:[3]
- Men who have sex with men.
- Immunosuppressed.
- HIV infection.
Microscopic
Features:
Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB)
Anus Squamous Cell Carcinoma (Non Keratinizing) - (SKB)
Anus Squamous Cell Carcinoma (Non Keratinizing or shall we say poorly keratinizing as there are squamatized nests focally at high power) - (SKB)
DDx:
- Anal gland adenocarcinoma.
- Poorly differentiated rectal adenocarcinoma.
IHC
Sign out
RECTUM, DISTAL, BIOPSY: - INVASIVE SQUAMOUS CELL CARCINOMA.
See also
- Anus.
References
- ↑ 1.0 1.1 Ghosn, M.; Kourie, HR.; Abdayem, P.; Antoun, J.; Nasr, D. (Feb 2015). "Anal cancer treatment: Current status and future perspectives.". World J Gastroenterol 21 (8): 2294-2302. doi:10.3748/wjg.v21.i8.2294. PMID 25741135.
- ↑ Cornall, AM.; Roberts, JM.; Garland, SM.; Hillman, RJ.; Grulich, AE.; Tabrizi, SN. (Nov 2013). "Anal and perianal squamous carcinomas and high-grade intraepithelial lesions exclusively associated with "low-risk" HPV genotypes 6 and 11.". Int J Cancer 133 (9): 2253-8. doi:10.1002/ijc.28228. PMID 23616200.
- ↑ Kutlubay, Z.; Engin, B.; Zara, T.; Tüzün, Y.. "Anogenital malignancies and premalignancies: Facts and controversies.". Clin Dermatol 31 (4): 362-73. doi:10.1016/j.clindermatol.2013.01.003. PMID 23806153.
- ↑ 4.0 4.1 Gunia, S.; Koch, S.; May, M. (Feb 2013). "Is CDX2 immunostaining useful for delineating anorectal from penile/vulvar squamous cancer in the setting of squamous cell carcinoma with clinically unknown primary site presenting with histologically confirmed inguinal lymph node metastasis?". J Clin Pathol 66 (2): 109-12. doi:10.1136/jclinpath-2012-201138. PMID 23105122.