Difference between revisions of "Angiokeratoma"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Angiokeratoma_- | | Image = Angiokeratoma_-_low_mag.jpg | ||
| Width = | | Width = | ||
| Caption = Angiokeratoma. [[H&E stain]]. | | Caption = Angiokeratoma. [[H&E stain]]. | ||
| Line 62: | Line 62: | ||
DDx: | DDx: | ||
*[[Venous lake]]. | *[[Venous lake]]. | ||
*Angiokeratoma-like changes in [[lichen sclerosus]].<ref name=pmid19187108>{{Cite journal | last1 = Luzar | first1 = B. | last2 = Neil | first2 = SM. | last3 = Calonje | first3 = E. | title = Angiokeratoma-like changes in extragenital and genital lichen sclerosus. | journal = J Cutan Pathol | volume = 36 | issue = 5 | pages = 540-2 | month = May | year = 2009 | doi = 10.1111/j.1600-0560.2008.01091.x | PMID = 19187108 }}</ref> | |||
===Images=== | ===Images=== | ||
Latest revision as of 17:36, 15 February 2015
| Angiokeratoma | |
|---|---|
| Diagnosis in short | |
 Angiokeratoma. H&E stain. | |
|
| |
| LM | ectatic superficial dermal vessels with overlying hyperkeratosis (thick stratum corneum); should have "epidermal collarette" (vascular space is surrounded by epidermis on three sides) |
| LM DDx | venous lake |
| Site | skin |
|
| |
| Syndromes | Fabry disease |
|
| |
| Prevalence | uncommon |
| Prognosis | benign |
| Clin. DDx | melanocytic lesions, other vascular lesions |
Angiokeratoma is a benign skin lesion.
General
- Rare.
- May be seen in the context of Fabry disease.[1]
Notes:
- Shouldn't be confused with angiofibroma which is associated tuberous sclerosis.
Gross
- Dark lesions.
Clinical DDx:
Images
Angiokeratoma. (WC)
Microscopic
Features:[1]
- Ectatic superficial dermal vessels.
- Overlying hyperkeratosis (thick stratum corneum).
- Should have "epidermal collarette".[2]
- Vascular space surrounded by epidermis on three sides.
Others features:[citation needed]
- Irregular acanthosis.
- Longer rete ridges.
DDx:
- Venous lake.
- Angiokeratoma-like changes in lichen sclerosus.[3]
Images
Angiokeratoma - low mag. (WC/Nephron)
Angiokeratoma - intermed. mag. (WC/Nephron)
Angiokeratoma - high mag. (WC/Nephron)
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SKIN LESION, LEFT POPITEAL FOSSA, PUNCH BIOPSY: - ANGIOKERATOMA.
See also
References
- ↑ 1.0 1.1 Karen, JK.; Hale, EK.; Ma, L. (2005). "Angiokeratoma corporis diffusum (Fabry disease).". Dermatol Online J 11 (4): 8. PMID 16403380.
- ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 548. ISBN 978-0443066542.
- ↑ Luzar, B.; Neil, SM.; Calonje, E. (May 2009). "Angiokeratoma-like changes in extragenital and genital lichen sclerosus.". J Cutan Pathol 36 (5): 540-2. doi:10.1111/j.1600-0560.2008.01091.x. PMID 19187108.