Difference between revisions of "Tumour suppressor gene"
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==Examples== | ==Examples== | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
! Gene | ! Gene | ||
| Line 14: | Line 13: | ||
|- | |- | ||
| RB1<ref>{{OMIM|614041}}</ref> | | RB1<ref>{{OMIM|614041}}</ref> | ||
| | | [[Retinoblastoma]] | ||
|- | |- | ||
| VHL<ref>{{OMIM|608537}}</ref> | | VHL<ref>{{OMIM|608537}}</ref> | ||
| Line 21: | Line 20: | ||
| NF1<ref>{{OMIM|613113}}</ref> | | NF1<ref>{{OMIM|613113}}</ref> | ||
| [[Neurofibromatosis type 1]] | | [[Neurofibromatosis type 1]] | ||
|- | |||
| TSC1<ref name=pmid11266527>{{Cite journal | last1 = Johnson | first1 = MW. | last2 = Kerfoot | first2 = C. | last3 = Bushnell | first3 = T. | last4 = Li | first4 = M. | last5 = Vinters | first5 = HV. | title = Hamartin and tuberin expression in human tissues. | journal = Mod Pathol | volume = 14 | issue = 3 | pages = 202-10 | month = Mar | year = 2001 | doi = 10.1038/modpathol.3880286 | PMID = 11266527 }}</ref> (hamartin) | |||
| [[Tuberous sclerosis]] | |||
|- | |||
| TSC2<ref name=pmid11266527/> (tuberin) | |||
| Tuberous sclerosis | |||
|} | |} | ||
Latest revision as of 06:13, 16 December 2014
A tumour suppressor gene is a gene that acts to protect the organism which it is within from developing cancer.
Examples
| Gene | Syndrome or disease |
|---|---|
| TP53 (p53)[1] | Li-Fraumeni syndrome |
| BRCA1[2] | Familial breast-ovarian cancer 1 |
| RB1[3] | Retinoblastoma |
| VHL[4] | Von Hippel-Lindau disease |
| NF1[5] | Neurofibromatosis type 1 |
| TSC1[6] (hamartin) | Tuberous sclerosis |
| TSC2[6] (tuberin) | Tuberous sclerosis |
See also
References
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 191170
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 113705
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 614041
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608537
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 613113
- ↑ 6.0 6.1 Johnson, MW.; Kerfoot, C.; Bushnell, T.; Li, M.; Vinters, HV. (Mar 2001). "Hamartin and tuberin expression in human tissues.". Mod Pathol 14 (3): 202-10. doi:10.1038/modpathol.3880286. PMID 11266527.