Difference between revisions of "Hamartoma"
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[[Image:Pulmonary hamartoma - low mag.jpg|thumb|right|250px|Micrograph of a [[pulmonary hamartoma]]. [[H&E stain]].]] | |||
A '''hamartoma''' is a:<ref>URL: [http://www.medterms.com/script/main/art.asp?articlekey=84157 http://www.medterms.com/script/main/art.asp?articlekey=84157]. Accessed on: 22 November 2010.</ref><ref name=Ref_PCPBoD8_147>{{Ref PCPBoD8|147}}</ref> | A '''hamartoma''' is a:<ref>URL: [http://www.medterms.com/script/main/art.asp?articlekey=84157 http://www.medterms.com/script/main/art.asp?articlekey=84157]. Accessed on: 22 November 2010.</ref><ref name=Ref_PCPBoD8_147>{{Ref PCPBoD8|147}}</ref> | ||
#Disorganized (non-neoplastic) growth (that may mimic a true neoplasm). | #Disorganized (non-neoplastic) growth (that may mimic a true neoplasm). | ||
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#Architecturally disorganized tissue that appears to be native to the site. | #Architecturally disorganized tissue that appears to be native to the site. | ||
#No significant growth (vis-à-vis the surrounding tissue). | #No significant growth (vis-à-vis the surrounding tissue). | ||
==Site specific== | ==Site specific== | ||
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*[[Pulmonary hamartoma]]. | *[[Pulmonary hamartoma]]. | ||
*[[Splenic hamartoma]]. | *[[Splenic hamartoma]]. | ||
*[[Neurocristic hamartoma]]. | |||
*[[Peutz-Jeghers polyp]]. | |||
*[[Fibrous hamartoma of infancy]]. | |||
==See also== | ==See also== | ||
*[[Basics]]. | *[[Basics]]. | ||
*[[Cancer]]. | *[[Cancer]]. | ||
*[[Odontoma]]. | |||
==References== | ==References== |
Latest revision as of 02:48, 30 November 2014
- Disorganized (non-neoplastic) growth (that may mimic a true neoplasm).
- May be clonal.
- May have recurrent genetic translocations.
- Composed of tissue of the region within it is found.
Note 1
- If #2 does not apply it is a choristoma.
- "Disorganized" in #1 separates it from:
- Hypertrophy and hyperplasia - which may be physiologic processes.
- The key differences between cancer and hamartoma are the ability of cancer to:
- Invade/destroy surrounding tissue.
- Metastasize.
- Considered clinically, growth is the difference between a benign tumour (measurable growth rate) and a hamartoma (no growth vis-à-vis the surrounding tissue).
- Hamartomas often consist of:
- Multiple cell types, e.g. Peutz-Jeghers polyps consist of normal submucosal elements.
- Have a well-circumscribed border.
Note 2
There is much confusion in this area as:
- Clonality is usually considered a characteristic of neoplasms.
- The line between benign tumour and hamartoma is thin, if one considers that a hamartoma can be clonal and some benign tumours have a slow growth rate.
- If one considers choristoma (hamartoma's cousin), the line between benign tumour (e.g. teratoma/dermoid cyst) and choristoma is thin.
A more useful definition of hamartoma might be:
- Architecturally disorganized tissue that appears to be native to the site.
- No significant growth (vis-à-vis the surrounding tissue).
Site specific
- Mammary hamartoma.
- Pulmonary hamartoma.
- Splenic hamartoma.
- Neurocristic hamartoma.
- Peutz-Jeghers polyp.
- Fibrous hamartoma of infancy.
See also
References
- ↑ URL: http://www.medterms.com/script/main/art.asp?articlekey=84157. Accessed on: 22 November 2010.
- ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 147. ISBN 978-1416054542.