Difference between revisions of "Clear cell adenocarcinoma of the urethra"
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*[http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3936309_gr1.jpg CCA of the urethra (nih.gov)].<ref name=pmid24389164/> | *[http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3936309_gr1.jpg CCA of the urethra (nih.gov)].<ref name=pmid24389164/> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479785/figure/F3/ CCA of the urethra (nih.gov)].<ref>{{Cite journal | last1 = Han | first1 = JY. | last2 = Kim | first2 = KH. | last3 = Kim | first3 = L. | last4 = Choi | first4 = SJ. | last5 = Park | first5 = IS. | last6 = Kim | first6 = JM. | last7 = Chu | first7 = YC. | last8 = Yoon | first8 = SM. | title = Cytologic findings of clear cell adenocarcinoma of the urethra: a case report. | journal = Korean J Pathol | volume = 46 | issue = 2 | pages = 210-4 | month = Apr | year = 2012 | doi = 10.4132/KoreanJPathol.2012.46.2.210 | PMID = 23110004 }}</ref> | |||
==IHC== | ==IHC== | ||
Revision as of 20:27, 13 November 2014
Clear cell adenocarcinoma of the urethra, also primary urethral clear cell adenocarcinoma, is a very rare malignant tumour of the urethra.
General
- Predominantly in women.[1]
Pathogenesis not well understood - may arise from:
- Muellerian rests or urothelium.[1]
- Shed kidney cells.[2]
- Nephrogenic adenoma - malignant transformation.[1]
Microscopic
Features:[1]
- Clear cells (at least focally).
- Columnar or cuboidal morphology.
- At least moderate nuclear pleomorphism.[2]
- Hobnailing (classic feature).
Note:
- Described as morphologically similar to clear cell adenocarcinoma of the gynecologic tract[2] - see clear cell carcinoma of the uterine cervix.
DDx:
- Nephrogenic adenoma[2] - also has hobnailing.
- Clear cell renal cell carcinoma.
- Clear cell adenocarcinoma of the gynecologic tract.
- Other clear cell tumours.
Images
www:
IHC
Features:[2]
- PAX8 +ve/-ve (2 +ve in 4 cases.
- CK7 +ve/-ve (2 +ve in 4 cases).
- Vimentin +ve (3 +ve in 4 cases).
- CK20 -ve/+ve (1 +ve in 4 cases).
Others:[2]
- ER -ve.
- p63 -ve.
- PSA -ve.
- p16 -ve.
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Mehra, R.; Vats, P.; Kalyana-Sundaram, S.; Udager, AM.; Roh, M.; Alva, A.; Pan, J.; Lonigro, RJ. et al. (Mar 2014). "Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.". Am J Pathol 184 (3): 584-91. doi:10.1016/j.ajpath.2013.11.023. PMID 24389164.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Alexiev, BA.; Tavora, F. (Feb 2013). "Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems.". Virchows Arch 462 (2): 193-201. doi:10.1007/s00428-012-1363-3. PMID 23307189.
- ↑ Han, JY.; Kim, KH.; Kim, L.; Choi, SJ.; Park, IS.; Kim, JM.; Chu, YC.; Yoon, SM. (Apr 2012). "Cytologic findings of clear cell adenocarcinoma of the urethra: a case report.". Korean J Pathol 46 (2): 210-4. doi:10.4132/KoreanJPathol.2012.46.2.210. PMID 23110004.