Difference between revisions of "Metaphyseal fibrous defect"
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*Self-limited | *Self-limited | ||
*Skeletally immature individuals, children and adolescent | *Skeletally immature individuals, children and adolescent | ||
*Often small lesions discovered an radiographic incidentaloma | *Often small lesions discovered as an radiographic incidentaloma | ||
*Rarely seen as a pathologic specimen (should not be biopsied) | |||
==Synonyms== | ==Synonyms== | ||
| Line 58: | Line 59: | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*Giant cell tumor of bone (epiphyseal location, occurs in adults) | *[[Giant cell tumor of bone]] (epiphyseal location, occurs in adults) | ||
==Relevant Diagnostic Groups== | ==Relevant Diagnostic Groups== | ||
| Line 86: | Line 87: | ||
*Incidental radiographic finding | *Incidental radiographic finding | ||
*Pathologic fracture | *Pathologic fracture | ||
==Prognosis== | |||
*Ideally should not be biopied | |||
*Radiographically characteristic and benign | |||
*On the 'skeletal do not touch list' <ref>http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1</ref> | |||
*Spontaneously resolve by ossification | |||
*May resolve into a 'bone island' | |||
==Radiographic findings== | ==Radiographic findings== | ||
| Line 91: | Line 99: | ||
==Sign out== | ==Sign out== | ||
BONE; CURETTAGE: | BONE; CURETTAGE: METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA. | ||
==See also== | ==See also== | ||
Revision as of 09:26, 14 October 2014
| Template:Metaphyseal fibrous defect | |
|---|---|
| Diagnosis in short | |
|
| |
| Synonyms | Nonossifying fibroma |
| Clinical history | Incidental radiograhic finding |
| Radiology | Lucent defect |
General
- Common
- Non-neoplastic
- Self-limited
- Skeletally immature individuals, children and adolescent
- Often small lesions discovered as an radiographic incidentaloma
- Rarely seen as a pathologic specimen (should not be biopsied)
Synonyms
- Nonossifying fibroma (larger but otherwise identical)
- Fibrous cortical defect
- Fibrous metaphyseal defect
- Fibroxanthoma of bone
Site
- Metaphysis of distal femur or proximal tibia (80%)
- Cortical
- Metaphysis
- Long bones
- Eccentric location
Gross
Firm, granular, brown to yellow to red
Microscopic
Spindle cells without cytologic atypia are arranged in a storiform pattern with scattered chronic inflammatory cells and benign giant cells. Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent.
Differential Diagnosis
- Giant cell tumor of bone (epiphyseal location, occurs in adults)
Relevant Diagnostic Groups
- FOG MACHINES - acronym for radiographically lytic bone lesions [1]
- Giant cell lesions of bone.
- Spindle cell lesions of bone.
Images
- http://njms2.umdnj.edu/tutorweb/casegifs/nofhe1.jpg
- http://njms2.umdnj.edu/tutorweb/casegifs/nofhe2.jpg
- http://njms2.umdnj.edu/tutorweb/casegifs/nofhe1.jpg
- http://pathologyoutlines.com/wick/non-ossifying%20fibroma%20(metaphyseal%20fibrous%20defect)%20micro.jpg
%20micro.jpg){kind=link}
Stains
Not relevant.
IHC
Not relevant
Molecular
Not relevant
Syndromes
Jaffe-Campanacci syndrome [2]
Clinical history
- Incidental radiographic finding
- Pathologic fracture
Prognosis
- Ideally should not be biopied
- Radiographically characteristic and benign
- On the 'skeletal do not touch list' [3]
- Spontaneously resolve by ossification
- May resolve into a 'bone island'
Radiographic findings
Sharply demarcated, lucent, loculated, meta-diaphyseal lesion surrounded by a rim of sclerotic bone
Sign out
BONE; CURETTAGE: METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA.
See also
- http://njms2.umdnj.edu/tutorweb/case8.htm
- http://www.pathologyoutlines.com/topic/bonemetaphysealfibrousdefect.html
- http://radiopaedia.org/articles/fibrous-cortical-defect
- http://radiopaedia.org/articles/non-ossifying-fibroma-1