Difference between revisions of "Anovulatory endometrium"
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'''Anovulatory endometrium''', abbreviated '''AE''', is common perimenopausal finding. It is a diagnosis that is inferred from the clinical context. | |||
==General== | |||
*Individuals usually perimenopausal. | |||
===Relation to disordered proliferative endometrium=== | |||
Some consider ''[[disordered proliferative endometrium]]'' (DPE) a synonym for ''anovulatory endometrium''.<ref>URL: [http://www.surgpath4u.com/caseviewer.php?case_no=382 http://www.surgpath4u.com/caseviewer.php?case_no=382]. Accessed on: 9 May 2013.</ref> | |||
''[[Libre Pathology]]'' separates the two. DPE has prominent gland dilation (reminiscent of [[simple endometrial hyperplasia]]) and may ''not'' have shedding. AE has shedding without gland dilation. | |||
==Microscopic== | |||
Features: | |||
*Shedding: | |||
**Stromal condensation. | |||
**Apoptotic endometrial epithelium. | |||
*Weakly proliferative glands or non-proliferative glands. | |||
DDx: | |||
*[[Disordered proliferative phase]] - gland dilation. | |||
*[[Simple endometrial hyperplasia]]. | |||
*[[Menstrual endometrium]] - should have mitoses,<ref name=Ref_DCHH237>{{Ref DCHH|237}}</ref> abundant [[PMN]]s. | |||
==Sign out== | |||
<pre> | |||
ENDOMETRIUM, CURETTAGE: | |||
- FRAGMENTED PROLIFERATIVE ENDOMETRIUM WITH EVIDENCE OF SHEDDING, WITHOUT ABUNDANT | |||
NEUTROPHILS, SEE COMMENT. | |||
- NO EVIDENCE OF HYPERPLASIA. | |||
- NEGATIVE FOR MALIGNANCY. | |||
COMMENT: | |||
The changes are compatible with anovulatory bleeding. | |||
</pre> | |||
<pre> | |||
ENDOMETRIUM, CURETTAGE: | |||
- PROLIFERATIVE ENDOMETRIUM WITH SMALL ROUND GLANDS AND SHEDDING, SEE COMMENT. | |||
- BENIGN ENDOCERVICAL MUCOSA. | |||
- NEGATIVE FOR HYPERPLASIA. | |||
- NEGATIVE FOR MALIGNANCY. | |||
COMMENT: | |||
The changes are suggestive of anovulatory bleeding. | |||
</pre> | |||
<pre> | |||
ENDOMETRIUM, BIOPSY: | |||
- BENIGN ENDOCERVICAL POLYP WITH ACUTE AND CHRONIC INFLAMMATION, AND EVIDENCE | |||
SUGGESTIVE OF EROSIONS (SIDEROPHAGES, INCREASED BLOOD VESSEL DENSITY). | |||
- SMALL NONPROLIFERATIVE ENDOMETRIAL GLANDS WITH RARE NEUTROPHILS AND RARE | |||
APOPTOTIC CELLS, WITH BALLS OF CONDENSED ENDOMETRIAL STROMA, SEE COMMENT. | |||
- NEGATIVE FOR ENDOMETRIAL HYPERPLASIA AND NEGATIVE FOR DYSPLASIA. | |||
COMMENT: | |||
The changes are suggestive of anovulatory bleeding. | |||
</pre> | |||
<pre> | |||
ENDOMETRIUM, ASPIRATION: | |||
- PSEUDOSTRATIFIED ENDOMETRIAL EPITHELIUM WITHOUT APPARENT PROLIFERATION, WITH | |||
APOPTOTIC CELLS AND LIMITED STROMA WITH RARE (STROMAL) CONDENSATION -- COMPATIBLE | |||
WITH SHEDDING. | |||
- MINUTE FRAGMENTS OF BENIGN ENDOCERVICAL EPITHELIUM. | |||
- NO EVIDENCE OF HYPERPLASIA. | |||
</pre> | |||
==See also== | |||
*[[Endometrium]]. | |||
*[[Disordered proliferative endometrium]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Endometrium]] | |||
Latest revision as of 13:05, 18 June 2014
Anovulatory endometrium, abbreviated AE, is common perimenopausal finding. It is a diagnosis that is inferred from the clinical context.
General
- Individuals usually perimenopausal.
Relation to disordered proliferative endometrium
Some consider disordered proliferative endometrium (DPE) a synonym for anovulatory endometrium.[1]
Libre Pathology separates the two. DPE has prominent gland dilation (reminiscent of simple endometrial hyperplasia) and may not have shedding. AE has shedding without gland dilation.
Microscopic
Features:
- Shedding:
- Stromal condensation.
- Apoptotic endometrial epithelium.
- Weakly proliferative glands or non-proliferative glands.
DDx:
- Disordered proliferative phase - gland dilation.
- Simple endometrial hyperplasia.
- Menstrual endometrium - should have mitoses,[2] abundant PMNs.
Sign out
ENDOMETRIUM, CURETTAGE: - FRAGMENTED PROLIFERATIVE ENDOMETRIUM WITH EVIDENCE OF SHEDDING, WITHOUT ABUNDANT NEUTROPHILS, SEE COMMENT. - NO EVIDENCE OF HYPERPLASIA. - NEGATIVE FOR MALIGNANCY. COMMENT: The changes are compatible with anovulatory bleeding.
ENDOMETRIUM, CURETTAGE: - PROLIFERATIVE ENDOMETRIUM WITH SMALL ROUND GLANDS AND SHEDDING, SEE COMMENT. - BENIGN ENDOCERVICAL MUCOSA. - NEGATIVE FOR HYPERPLASIA. - NEGATIVE FOR MALIGNANCY. COMMENT: The changes are suggestive of anovulatory bleeding.
ENDOMETRIUM, BIOPSY: - BENIGN ENDOCERVICAL POLYP WITH ACUTE AND CHRONIC INFLAMMATION, AND EVIDENCE SUGGESTIVE OF EROSIONS (SIDEROPHAGES, INCREASED BLOOD VESSEL DENSITY). - SMALL NONPROLIFERATIVE ENDOMETRIAL GLANDS WITH RARE NEUTROPHILS AND RARE APOPTOTIC CELLS, WITH BALLS OF CONDENSED ENDOMETRIAL STROMA, SEE COMMENT. - NEGATIVE FOR ENDOMETRIAL HYPERPLASIA AND NEGATIVE FOR DYSPLASIA. COMMENT: The changes are suggestive of anovulatory bleeding.
ENDOMETRIUM, ASPIRATION: - PSEUDOSTRATIFIED ENDOMETRIAL EPITHELIUM WITHOUT APPARENT PROLIFERATION, WITH APOPTOTIC CELLS AND LIMITED STROMA WITH RARE (STROMAL) CONDENSATION -- COMPATIBLE WITH SHEDDING. - MINUTE FRAGMENTS OF BENIGN ENDOCERVICAL EPITHELIUM. - NO EVIDENCE OF HYPERPLASIA.
See also
References
- ↑ URL: http://www.surgpath4u.com/caseviewer.php?case_no=382. Accessed on: 9 May 2013.
- ↑ Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 237. ISBN 978-0470519035.