Difference between revisions of "Atrophy of the prostate gland"

From Libre Pathology
Jump to navigation Jump to search
(more)
(tweak)
Line 2: Line 2:


It usually is seen focally; thus, it is sometimes called '''partial prostatic atrophy'''.
It usually is seen focally; thus, it is sometimes called '''partial prostatic atrophy'''.
On occasion, it can mimic [[prostate carcinoma]], especially ''[[atrophic prostate carcinoma]]''.


==General==
==General==
*Considered to be the most common mimicker of [[prostate carcinoma]].<ref name=pmid18408595>{{Cite journal  | last1 = Wang | first1 = W. | last2 = Sun | first2 = X. | last3 = Epstein | first3 = JI. | title = Partial atrophy on prostate needle biopsy cores: a morphologic and immunohistochemical study. | journal = Am J Surg Pathol | volume = 32 | issue = 6 | pages = 851-7 | month = Jun | year = 2008 | doi = 10.1097/PAS.0b013e31815a0508 | PMID = 18408595 }}</ref>
*Small glands (may mimic Gleason score 3 pattern).
*Small glands (may mimic Gleason score 3 pattern).
*Inflammatory atrophy seems to be related to [[HGPIN]] and [[prostate cancer]];<ref name=pmid10595928>{{Cite journal  | last1 = De Marzo | first1 = AM. | last2 = Marchi | first2 = VL. | last3 = Epstein | first3 = JI. | last4 = Nelson | first4 = WG. | title = Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. | journal = Am J Pathol | volume = 155 | issue = 6 | pages = 1985-92 | month = Dec | year = 1999 | doi = 10.1016/S0002-9440(10)65517-4 | PMID = 10595928 }}</ref> however, the epidemiology is not compelling that this is a significant (clinical) association.<ref name=pmid24129226>{{Cite journal  | last1 = Celma | first1 = A. | last2 = Servián | first2 = P. | last3 = Planas | first3 = J. | last4 = Placer | first4 = J. | last5 = Quilez | first5 = MT. | last6 = Arbós | first6 = MA. | last7 = de Torres | first7 = I. | last8 = Morote | first8 = J. | title = Clinical Significance of Proliferative Inflammatory Atrophy in Prostate Biopsy. | journal = Actas Urol Esp | volume = 38 | issue = 2 | pages = 122-126 | month = Mar | year = 2014 | doi = 10.1016/j.acuro.2013.04.008 | PMID = 24129226 }}</ref>
*Inflammatory atrophy seems to be related to [[HGPIN]] and [[prostate cancer]];<ref name=pmid10595928>{{Cite journal  | last1 = De Marzo | first1 = AM. | last2 = Marchi | first2 = VL. | last3 = Epstein | first3 = JI. | last4 = Nelson | first4 = WG. | title = Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. | journal = Am J Pathol | volume = 155 | issue = 6 | pages = 1985-92 | month = Dec | year = 1999 | doi = 10.1016/S0002-9440(10)65517-4 | PMID = 10595928 }}</ref> however, the epidemiology is not compelling that this is a significant (clinical) association.<ref name=pmid24129226>{{Cite journal  | last1 = Celma | first1 = A. | last2 = Servián | first2 = P. | last3 = Planas | first3 = J. | last4 = Placer | first4 = J. | last5 = Quilez | first5 = MT. | last6 = Arbós | first6 = MA. | last7 = de Torres | first7 = I. | last8 = Morote | first8 = J. | title = Clinical Significance of Proliferative Inflammatory Atrophy in Prostate Biopsy. | journal = Actas Urol Esp | volume = 38 | issue = 2 | pages = 122-126 | month = Mar | year = 2014 | doi = 10.1016/j.acuro.2013.04.008 | PMID = 24129226 }}</ref>

Revision as of 02:01, 29 April 2014

Atrophy of the prostate gland, also prostatic atrophy, is a common change in the prostate gland.

It usually is seen focally; thus, it is sometimes called partial prostatic atrophy.

General

  • Considered to be the most common mimicker of prostate carcinoma.[1]
  • Small glands (may mimic Gleason score 3 pattern).
  • Inflammatory atrophy seems to be related to HGPIN and prostate cancer;[2] however, the epidemiology is not compelling that this is a significant (clinical) association.[3]

Microscopic

Features:

  • Glands often have a jagged edges/prows (in cancer the glands tend to have round edges) - key feature.
    • Prow = forward most part of a ship's bow that cuts through the water.[4]
      • You may have come across prow in the context of breast cancer, i.e. tubular carcinoma.
  • Gland density is usually lower than in prostate carcinoma, i.e. glands are not back-to-back - key feature.
  • Atrophic glands are often hyperchromatic.[5]
  • Scant cytoplasm - usually.

Negatives:

  • Nuclei like normal, i.e. nucleoli uncommon.
  • Should have two cell layers, i.e. epithelial and myoepithelial (may be difficult to see).

Notes:

  • Atrophic glands may be scattered with non-atrophic ones.
  • IHC may be misleading - basal cell loss.

DDx:

Atrophy versus cancer

Histologic feature Atrophy Cancer
Glandular architecture/
arrangement 		angulated glands, may
look like they originate
from one large duct 		round glands,
often back-to-back
Nuclear
hyperchromasia 		marked moderate
Cytoplasm scant/minimal moderate, may
be amphophilic
Basal cells may be visible absent
Nucleoli absent present
Secretions in
glands 		no yes - eosinophilic
or blue

Sign out

Generally, this finding is not reported; it is considered a normal finding.

See also

References

  1. ↑ Wang, W.; Sun, X.; Epstein, JI. (Jun 2008). "Partial atrophy on prostate needle biopsy cores: a morphologic and immunohistochemical study.". Am J Surg Pathol 32 (6): 851-7. doi:10.1097/PAS.0b013e31815a0508. PMID 18408595.
  2. ↑ De Marzo, AM.; Marchi, VL.; Epstein, JI.; Nelson, WG. (Dec 1999). "Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis.". Am J Pathol 155 (6): 1985-92. doi:10.1016/S0002-9440(10)65517-4. PMID 10595928.
  3. ↑ Celma, A.; Servián, P.; Planas, J.; Placer, J.; Quilez, MT.; Arbós, MA.; de Torres, I.; Morote, J. (Mar 2014). "Clinical Significance of Proliferative Inflammatory Atrophy in Prostate Biopsy.". Actas Urol Esp 38 (2): 122-126. doi:10.1016/j.acuro.2013.04.008. PMID 24129226.
  4. ↑ http://en.wikipedia.org/wiki/Prow
  5. ↑ SN. June 3, 2009.
Retrieved from "https://librepathology.org/w/index.php?title=Atrophy_of_the_prostate_gland&oldid=31185"