Difference between revisions of "Splenic hamartoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Splenic_hamartoma_-_very_low_mag.jpg | |||
| Width = | |||
| Caption = Splenic hamartoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = variable size irregular vascular channels, red pulp-like disorganized stroma, +/-lymphoid follicles | |||
| Subtypes = | |||
| LMDDx = [[littoral cell angioma]] | |||
| Stains = | |||
| IHC = factor VIII +ve, CD31 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = red, well-circumscribed | |||
| Grossing = | |||
| Site = [[spleen]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = +/-splenic enlargement | |||
| Symptoms = +/-abdominal pain | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = observe or splenectomy | |||
}} | |||
'''Splenic hamartoma''', also '''[[hamartoma]] of the spleen''', is an uncommon benign lesion of the [[spleen]]. | |||
==General== | |||
*Benign. | |||
*Women > men.<ref name=pmid21393931>{{Cite journal | last1 = Sankar | first1 = S. | last2 = Thanka | first2 = J. | last3 = Jagdishchandrabose | first3 = S. | last4 = Rajendran | first4 = S. | title = Splenic hamartoma: a rare vascular space occupying lesion of the spleen. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 223-5 | month = | year = | doi = 10.4103/0377-4929.77416 | PMID = 21393931 }}</ref> | |||
*May cause pain.<ref>{{Cite journal | last1 = Tatekawa | first1 = Y. | last2 = Kanehiro | first2 = H. | last3 = Nakajima | first3 = Y. | title = Laparoscopic extirpation of splenic hamartoma. | journal = Pediatr Surg Int | volume = 23 | issue = 9 | pages = 911-4 | month = Sep | year = 2007 | doi = 10.1007/s00383-007-1902-1 | PMID = 17364201 }}</ref> | |||
==Gross== | |||
*Red lesion. | |||
*Well-circumscribed. | |||
===Image=== | |||
<gallery> | |||
Image:Spleen_hamartom.jpg | Splenic hamartoma. (WC) | |||
</gallery> | |||
==Microscopic== | |||
Features:<ref name=pmid19123729/> | |||
*Variable size irregular vascular channels | |||
*Red pulp-like disorganized stroma | |||
*+/-Lymphoid follicles. | |||
DDx: | |||
*[[Littoral cell angioma]]. | |||
===Images=== | |||
<gallery> | |||
Image: Splenic hamartoma - very low mag.jpg | Splenic hamartoma - very low mag. (WC) | |||
Image: Splenic hamartoma - low mag.jpg | Splenic hamartoma - low mag. (WC) | |||
Image: Splenic hamartoma - intermed mag.jpg | Splenic hamartoma - intermed. mag. (WC) | |||
Image: Splenic hamartoma - add - intermed mag.jpg | Splenic hamartoma - intermed. mag. (WC) | |||
Image: Splenic hamartoma - high mag.jpg | Splenic hamartoma - high mag. (WC) | |||
Image: Splenic hamartoma - very high mag.jpg | Splenic hamartoma - very high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
Features: | |||
*CD8 +ve endothelial cells.<ref name=pmid19123729>{{Cite journal | last1 = Lee | first1 = H. | last2 = Maeda | first2 = K. | title = Hamartoma of the spleen. | journal = Arch Pathol Lab Med | volume = 133 | issue = 1 | pages = 147-51 | month = Jan | year = 2009 | doi = 10.1043/1543-2165-133.1.147 | PMID = 19123729 }}</ref> | |||
*Factor VIII +ve (diffuse intense).<ref name=pmid15735864>{{Cite journal | last1 = Ali | first1 = TZ. | last2 = Beyer | first2 = G. | last3 = Taylor | first3 = M. | last4 = Volpe | first4 = C. | last5 = Papadimitriou | first5 = JC. | title = Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases. | journal = Int J Surg Pathol | volume = 13 | issue = 1 | pages = 103-11 | month = Jan | year = 2005 | doi = | PMID = 15735864 }}</ref> | |||
**Background spleen -ve. | |||
*CD31 -ve.<ref name=pmid15735864/> | |||
**Background spleen +ve. | |||
==See also== | |||
*[[Spleen]]. | |||
*[[Hamartoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Spleen]] | |||
[[Category:Diagnosis]] | |||
Latest revision as of 02:03, 9 April 2014
| Splenic hamartoma | |
|---|---|
| Diagnosis in short | |
 Splenic hamartoma. H&E stain. | |
|
| |
| LM | variable size irregular vascular channels, red pulp-like disorganized stroma, +/-lymphoid follicles |
| LM DDx | littoral cell angioma |
| IHC | factor VIII +ve, CD31 -ve |
| Gross | red, well-circumscribed |
| Site | spleen |
|
| |
| Signs | +/-splenic enlargement |
| Symptoms | +/-abdominal pain |
| Prognosis | benign |
| Treatment | observe or splenectomy |
Splenic hamartoma, also hamartoma of the spleen, is an uncommon benign lesion of the spleen.
General
Gross
- Red lesion.
- Well-circumscribed.
Image
Splenic hamartoma. (WC)
Microscopic
Features:[3]
- Variable size irregular vascular channels
- Red pulp-like disorganized stroma
- +/-Lymphoid follicles.
DDx:
Images
Splenic hamartoma - very low mag. (WC)
Splenic hamartoma - low mag. (WC)
Splenic hamartoma - intermed. mag. (WC)
Splenic hamartoma - intermed. mag. (WC)
Splenic hamartoma - high mag. (WC)
Splenic hamartoma - very high mag. (WC)
IHC
Features:
- CD8 +ve endothelial cells.[3]
- Factor VIII +ve (diffuse intense).[4]
- Background spleen -ve.
- CD31 -ve.[4]
- Background spleen +ve.
See also
References
- ↑ Sankar, S.; Thanka, J.; Jagdishchandrabose, S.; Rajendran, S.. "Splenic hamartoma: a rare vascular space occupying lesion of the spleen.". Indian J Pathol Microbiol 54 (1): 223-5. doi:10.4103/0377-4929.77416. PMID 21393931.
- ↑ Tatekawa, Y.; Kanehiro, H.; Nakajima, Y. (Sep 2007). "Laparoscopic extirpation of splenic hamartoma.". Pediatr Surg Int 23 (9): 911-4. doi:10.1007/s00383-007-1902-1. PMID 17364201.
- ↑ 3.0 3.1 Lee, H.; Maeda, K. (Jan 2009). "Hamartoma of the spleen.". Arch Pathol Lab Med 133 (1): 147-51. doi:10.1043/1543-2165-133.1.147. PMID 19123729.
- ↑ 4.0 4.1 Ali, TZ.; Beyer, G.; Taylor, M.; Volpe, C.; Papadimitriou, JC. (Jan 2005). "Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases.". Int J Surg Pathol 13 (1): 103-11. PMID 15735864.