Difference between revisions of "Basal crypt dysplasia"
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It may be referred to as '''crypt dysplasia-like atypia'''<ref name=pmid16625087>{{Cite journal | last1 = Lomo | first1 = LC. | last2 = Blount | first2 = PL. | last3 = Sanchez | first3 = CA. | last4 = Li | first4 = X. | last5 = Galipeau | first5 = PC. | last6 = Cowan | first6 = DS. | last7 = Ayub | first7 = K. | last8 = Rabinovitch | first8 = PS. | last9 = Reid | first9 = BJ. | title = Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort. | journal = Am J Surg Pathol | volume = 30 | issue = 4 | pages = 423-35 | month = Apr | year = 2006 | doi = | PMID = 16625087 }}</ref> and '''crypt dysplasia''' (abbreviated '''CD'''). | It may be referred to as '''crypt dysplasia-like atypia'''<ref name=pmid16625087>{{Cite journal | last1 = Lomo | first1 = LC. | last2 = Blount | first2 = PL. | last3 = Sanchez | first3 = CA. | last4 = Li | first4 = X. | last5 = Galipeau | first5 = PC. | last6 = Cowan | first6 = DS. | last7 = Ayub | first7 = K. | last8 = Rabinovitch | first8 = PS. | last9 = Reid | first9 = BJ. | title = Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort. | journal = Am J Surg Pathol | volume = 30 | issue = 4 | pages = 423-35 | month = Apr | year = 2006 | doi = | PMID = 16625087 }}</ref> and '''crypt dysplasia''' (abbreviated '''CD'''). | ||
The conventional thinking has been that dysplasia ''always'' involve the surface epithelium; BCD violates the saying ''normal is '''d'''ark '''d'''eep and '''l'''ight '''l'''uminal.'' This entity is consider to be an emerging concept;<ref name=pmid21970480>{{Cite journal | last1 = Voltaggio | first1 = L. | last2 = Montgomery | first2 = EA. | last3 = Lam-Himlin | first3 = D. | title = A clinical and histopathologic focus on Barrett esophagus and Barrett-related dysplasia. | journal = Arch Pathol Lab Med | volume = 135 | issue = 10 | pages = 1249-60 | month = Oct | year = 2011 | doi = 10.5858/arpa.2011-0019-RA | PMID = 21970480 }}</ref> it is not completely without controversy. | |||
BCD violates the saying ''normal is '''d'''ark '''d'''eep and '''l'''ight '''l'''uminal.'' | |||
==General== | ==General== | ||
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*Strong association with conventional dysplasia/adenocarcinoma. | *Strong association with conventional dysplasia/adenocarcinoma. | ||
**In one series, 87% of individual with BCD had dysplasia ''or'' adenocarcinoma in other tissue samples.<ref name=pmid16625087/> | **In one series, 87% of individual with BCD had dysplasia ''or'' adenocarcinoma in other tissue samples.<ref name=pmid16625087/> | ||
*Reproducibility among pathologists is worse than [[columnar dysplasia of the esophagus|high-grade dysplasia]] but better than low-grade dysplasia.<ref name=pmid21970480/> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 12:04, 2 April 2014
Basal crypt dysplasia, abbreviated BCD, is a dysplastic change reported in the esophagus that involves the crypt bases but not the surface.[1]
It may be referred to as crypt dysplasia-like atypia[2] and crypt dysplasia (abbreviated CD).
The conventional thinking has been that dysplasia always involve the surface epithelium; BCD violates the saying normal is dark deep and light luminal. This entity is consider to be an emerging concept;[3] it is not completely without controversy.
General
- Molecular changes in the crypt base can be identified in the surface cells.[1]
- Strong association with conventional dysplasia/adenocarcinoma.
- In one series, 87% of individual with BCD had dysplasia or adenocarcinoma in other tissue samples.[2]
- Reproducibility among pathologists is worse than high-grade dysplasia but better than low-grade dysplasia.[3]
Microscopic
Features:
- Definite "dysplastic changes" in the crypt base:
- Hyperchromasia - important.
- Nuclear enlargement.
- Nuclear crowding (pseudostratification).
- Non-dysplastic (normal) surface epithelium.[1]
See also
References
- ↑ 1.0 1.1 1.2 Khan, S.; McDonald, SA.; Wright, NA.; Graham, TA.; Odze, RD.; Rodriguez-Justo, M.; Zeki, S. (Sep 2013). "Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells.". J Pathol 231 (1): 98-104. doi:10.1002/path.4211. PMID 23695891.
- ↑ 2.0 2.1 Lomo, LC.; Blount, PL.; Sanchez, CA.; Li, X.; Galipeau, PC.; Cowan, DS.; Ayub, K.; Rabinovitch, PS. et al. (Apr 2006). "Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort.". Am J Surg Pathol 30 (4): 423-35. PMID 16625087.
- ↑ 3.0 3.1 Voltaggio, L.; Montgomery, EA.; Lam-Himlin, D. (Oct 2011). "A clinical and histopathologic focus on Barrett esophagus and Barrett-related dysplasia.". Arch Pathol Lab Med 135 (10): 1249-60. doi:10.5858/arpa.2011-0019-RA. PMID 21970480.