Difference between revisions of "Bile duct adenoma"
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==General== | ==General== | ||
*Benign. | *Benign. | ||
*Important as it can be misdiagnosed as cancer. | *Important as it can be misdiagnosed as [[cancer]]. | ||
==Microscopic== | ==Microscopic== | ||
| Line 19: | Line 19: | ||
DDx: | DDx: | ||
*[[Cholangiocarcinoma]]. | *[[Cholangiocarcinoma]]. | ||
*Metastatic adenocarcinoma. | *Metastatic adenocarcinoma. | ||
**[[Pancreatic ductal adenocarcinoma]].<ref name=pmid15725808>{{Cite journal | last1 = Hornick | first1 = JL. | last2 = Lauwers | first2 = GY. | last3 = Odze | first3 = RD. | title = Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. | journal = Am J Surg Pathol | volume = 29 | issue = 3 | pages = 381-9 | month = Mar | year = 2005 | doi = | PMID = 15725808 }}</ref> | |||
*[[Bile duct hamartoma]] (von Meyenburg complex). | *[[Bile duct hamartoma]] (von Meyenburg complex). | ||
Revision as of 01:28, 7 March 2014
Bile duct adenoma is a benign liver lesion characterized composed of bile duct epithelium.
It is also known as a benign bile duct proliferation.[1]
General
- Benign.
- Important as it can be misdiagnosed as cancer.
Microscopic
Features:
- Disordered bile ducts within in a fibrotic stroma.
- No (yellow) bile within, as these lesions do not have a connection to the biliary tree.
- +/-Lymphocytic cuff.
Negatives:
- No mitotic activity.
- No necrosis.
DDx:
- Cholangiocarcinoma.
- Metastatic adenocarcinoma.
- Bile duct hamartoma (von Meyenburg complex).
Images
IHC
- CK7 +ve.
- HepPar-1 -ve.
- Ki-67 low.
Others:[2]
- p53 -ve.
- mCEA -ve.
See also
References
- ↑ Johannesen, EJ.; Wu, Z.; Holly, JS. (2014). "Bile duct adenoma with oncocytic features.". Case Rep Pathol 2014: 282010. doi:10.1155/2014/282010. PMID 24592348.
- ↑ 2.0 2.1 Hornick, JL.; Lauwers, GY.; Odze, RD. (Mar 2005). "Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver.". Am J Surg Pathol 29 (3): 381-9. PMID 15725808.