Difference between revisions of "Solitary fibrous tumour"
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'''Solitary fibrous tumour''', abbreviated '''SFT''', is a type of [[soft tissue lesion|soft tissue tumour]] that fits in the [[fibroblastic/myofibroblastic tumours]]. It is usually benign. | '''Solitary fibrous tumour''', abbreviated '''SFT''', is a type of [[soft tissue lesion|soft tissue tumour]] that fits in the [[fibroblastic/myofibroblastic tumours]]. It is usually benign. | ||
SFT of the pleura is dealt with in a separate article ''[[solitary fibrous tumour of the pleura]]''. | |||
==General== | ==General== | ||
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==Gross== | ==Gross== | ||
* | *Soft tissue mass. | ||
==Microscopic== | ==Microscopic== | ||
Revision as of 03:41, 18 February 2014
| Solitary fibrous tumour | |
|---|---|
| Diagnosis in short | |
 Solitary fibrous tumour. H&E stain. | |
|
| |
| LM | spindle cells in a patternless pattern, hemangiopericytoma-like areas (staghorn vessels), keloid-like collagen bundles, +/-well-circumscribed (common) |
| Subtypes | benign (common), malignant (uncommon) |
| IHC | CD34 ~90% +ve, CD99 ~70% +ve, BCL2 ~50% +ve |
| Site | soft tissue - fibroblastic/myofibroblastic tumours, pleura |
|
| |
| Syndromes | Doege-Potter syndrome |
|
| |
| Prognosis | usu. good |
Solitary fibrous tumour, abbreviated SFT, is a type of soft tissue tumour that fits in the fibroblastic/myofibroblastic tumours. It is usually benign.
SFT of the pleura is dealt with in a separate article solitary fibrous tumour of the pleura.
General
- Grouped with hemangiopericytoma in the WHO classification - as it is thought to be the same tumour.[1]
- May be benign or malignant; more commonly benign.[2][3]
- May be associated with hypoglycemia.
- Known as Doege-Potter syndrome.[4]
Gross
- Soft tissue mass.
Microscopic
Features - benign:
- Spindle cells in a patternless pattern.
- Hemangiopericytoma-like area (staghorn vessels).
- Keloid-like collagen bundles - key feature.
- +/-Well-circumscribed (common).
Criteria for malignancy:[1]
- Necrosis.
- Mitoses >4/10 HPF -- definition suffers from HPFitis.
- Increased cellularity.
- Marked nuclear atypia.
- Infiltrative margin.
Images
Benign SFT - low mag. (WC)
Benign SFT - intermed. mag. (WC)
Benign SFT - high mag. (WC)
www:
IHC
- CD34 ~90% +ve.
- CD99 ~70% +ve.
- BCL2 ~50% +ve.
See also
References
- ↑ 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 609. ISBN 978-0781765275.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970528-9. Accessed on: 25 June 2010.
- ↑ URL: http://wjso.com/content/6/1/86. Accessed on: 25 June 2010.
- ↑ Roy, TM.; Burns, MV.; Overly, DJ.; Curd, BT. (Nov 1992). "Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome.". J Ky Med Assoc 90 (11): 557-60. PMID 1474302.